Donor-Recipient Gender Mismatch Affects Early Graft Loss After Kidney Transplantation

Żukowski, Maciej; Kotfis, Katarzyna; Biernawska, Jowita; Zegan-Barańska, Małgorzata; Kaczmarczyk, Mariusz; Ciechanowicz, Andrzej; Brykczyński, Mirosław; Ostrowski, Marek; Nikodemski, Tomasz; Bohatyrewicz, Romuald

doi:10.1016/j.transproceed.2011.08.068

Cited by 21 publications

(15 citation statements)

References 7 publications

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“…A specific aim of this study was to examine the possible association between deceased donor type and EGL in a cohort which consisted of a high proportion of transplants from DCD and ECD donors; previous studies made no distinction between DCD and DBD donors (3,13). Our results show that while EGL was more frequent among DCD and ECD kidney recipients, the long-term outcomes were similar between DCD versus DBD kidney recipients, which is consistent with the findings of previous studies (6,14,15).…”

Section: Discussionsupporting

confidence: 89%

Early Graft Loss After Kidney Transplantation: Risk Factors and Consequences

Hamed

Chen²,

Pasea

et al. 2015

American Journal of Transplantation

101

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Early graft loss (EGL) after kidney transplantation is a catastrophic outcome that is assumed to be more likely after the use of kidneys from suboptimal donors. We therefore examined its incidence, risk factors and consequences in our center in relation to different donor types. Of 801 recipients who received a kidney-only transplant from deceased donors, 50 (6.2%) suffered EGL within 30 days of transplantation. Significant risks factors for EGL were donation after circulatory death (DCD) (odds ratio [OR] 2.88; p ¼ 0.006), expanded criteria donor (ECD) transplantation (OR 4.22; p ¼ 0.010), donor age (OR 1.03; p ¼ 0.044) and recipient past history of thrombosis (OR 4.91; p ¼ 0.001). Recipients with EGL had 12.28 times increased risk of death within the first year, but long-term survival was worse for patients remaining on the waiting list. In comparison with patients on the waiting list but not transplanted, and with all patients on the waiting list, the risk of death after EGL decreased to baseline 4 and 23 months after transplantation, respectively. Our findings suggest that DCD and ECD transplantation are significant risk factors for EGL, which is a major risk factor for recipient death. However, long-term mortality is even greater for those remaining on the waiting list.

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Section: Discussionsupporting

confidence: 89%

Early Graft Loss After Kidney Transplantation: Risk Factors and Consequences

Hamed

Chen²,

Pasea

et al. 2015

American Journal of Transplantation

101

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show abstract

“…After review of the abstract, 904 were excluded and later a further 17 were excluded by review of the full text. The remaining 14 studies met the inclusion criteria . The included studies enrolled a total of 445 279 patients who underwent kidney transplantation.…”

Section: Resultsmentioning

confidence: 99%

The effect of donor‐recipient gender mismatch on short‐ and long‐term graft survival in kidney transplantation: a systematic review and meta‐analysis

Zhou

Cheng

Huang

et al. 2013

Clinical Transplantation

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“…size mismatch), immunological barriers, hormonal influences on the endothelium, and gender differences in susceptibility to ischemia/reperfusion. One study reports worse renal allograft survival in female recipients of male kidneys; postulating that maternal presensitization may play a role (14). Furthermore, there is a higher rate of rejection episodes requiring treatment following female-to-male kidney transplantation, speaking to possible immunological causes of graft failure.…”

Section: Discussionmentioning

confidence: 99%

Overcoming Cross-Gender Differences and Challenges in Le Fort–Based, Craniomaxillofacial Transplantation With Enhanced Computer-Assisted Technology

Gordon

Swanson

Susarla

et al. 2013

Annals of Plastic Surgery

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Background Gender-specific anthropometrics, skin texture/adnexae mismatch, and social apprehension have prevented cross-gender facial transplantation from evolving. However, the scarce donor pool and extreme waitlist times are currently suboptimal. Our objective was to: 1) perform and assess cadaveric facial transplantation for each gender-mismatch scenario employing virtual panning with cutting guide fabrication and 2) review the advantages/disadvantages of cross-gender facial transplantation. Methods Cross-gender facial transplantation feasibility was evaluated through two mock, double-jaw, Le Fort-based cadaveric allotransplants, including female donor-to-male recipient (T1-FM) and male donor-to-female recipient (T2-MF). Hybrid facial-skeletal relationships were investigated using cephalometric measurements, including sellion-nasion-A point (SNA) and sellion-nasion-B point (SNB) angles, and lower-anterior-facial-height to total-anterior-facial-height ratio (LAFH/TAFH). Donor and recipient cutting guides were designed with virtual planning based on our team’s experience in swine dissections and used to optimize the results. Results Skeletal proportions and facial-aesthetic harmony of the transplants [n=2] were found to be equivalent to all reported experimental/clinical gender-matched cases by using custom guides and Mimics technology. Cephalometric measurements are shown in Table 1 relative to Eastman Normal Values. Conclusions Based on our results, we believe that cross-gender facial transplantation can offer equivalent, anatomical skeletal outcomes to those of gender-matched pairs using pre-operative planning and custom guides for execution. Lack of literature discussion of cross-gender facial transplantation highlights the general stigmata encompassing the subject. We hypothesize that concerns over gender-specific anthropometrics, skin texture/adnexae disparity, and increased immunological resistance have prevented full acceptance thus far. Advantages include an increased donor pool with expedited reconstruction, as well as size-matched donors.

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Donor-Recipient Gender Mismatch Affects Early Graft Loss After Kidney Transplantation

Cited by 21 publications

References 7 publications

Early Graft Loss After Kidney Transplantation: Risk Factors and Consequences

Early Graft Loss After Kidney Transplantation: Risk Factors and Consequences

The effect of donor‐recipient gender mismatch on short‐ and long‐term graft survival in kidney transplantation: a systematic review and meta‐analysis

Overcoming Cross-Gender Differences and Challenges in Le Fort–Based, Craniomaxillofacial Transplantation With Enhanced Computer-Assisted Technology

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