The effect of donor‐recipient gender mismatch on short‐ and long‐term graft survival in kidney transplantation: a systematic review and meta‐analysis

Zhou, Jingyi; Cheng, Jun; Huang, Hongfeng; Shen, Yi; Jiang, Yan; Chen, Jianghua

doi:10.1111/ctr.12191

Cited by 36 publications

(37 citation statements)

References 30 publications

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“…Sex-based differences are ascribed to donor-recipient size mismatching and exposure to H-Y minor histocompatibility (1)(2)(3)(4). However, a focus on size-and immune-mediated effects has ignored the association between sex and ischemia-reperfusion injury (IRI).…”

Section: Introductionmentioning

confidence: 99%

Improved renal ischemia tolerance in females influences kidney transplantation outcomes

Aufhauser¹,

Wang²,

Murken³

et al. 2016

Journal of Clinical Investigation

116

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Section: Introductionmentioning

confidence: 99%

Improved renal ischemia tolerance in females influences kidney transplantation outcomes

Aufhauser¹,

Wang²,

Murken³

et al. 2016

Journal of Clinical Investigation

116

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“…As a result, female donors provide fewer nephrons compared with males. 29 This was a retrospective study, and consequently it was necessary to make key assumptions about specific details of transplantation. These assumptions were made using appropriate clinical judgment in an attempt to best reflect the data present in the database and reflect clinical practice during the study.…”

mentioning

confidence: 99%

One-year survival rate of renal transplant: factors influencing the outcome

Rezapour¹,

Yarmohammadi²,

Tavakkoli³

2017

TRRM

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Background: Renal transplantation remains the treatment of choice for end-stage renal disease, as the procedure not only improves quality of life, but also markedly increases patients' survival rates. Organ and patient survival rates are important issues of interest post-transplantation. Aim: To determine the 1-year survival rate of renal transplant, we studied graft function, which is a predictor of survival, among those who received a kidney transplant in the time period between February 2012 and February 2013 at Montaserie Organ Transplantation Hospital. Materials and methods: This is a retrospective cohort study planned to determine patient and organ survival rates after kidney transplantation from living and deceased donors during a 1-year period. We also tried to clarify factors resulting in graft loss. Designated variables were collected using checklists and subsequently entered into SPSS software version 17 and analyzed using the Kaplan-Meier method and descriptive statistics. Results: From 173 patients included in the study, 67.1% (n=116) were female. The mean age of the recipients was 33±12.85 years. In the majority of cases, cause of end-stage renal disease was not clear (n=89, 51.44%). Urinary tract infection (23.1%) was the commonest post-operative complication, followed by delayed graft function, which was diagnosed in 22 (12.7%) recipients. Seventeen cases of graft rejection (9.8%) were recorded and 4 (2.3%) of these cases underwent nephrectomy that will be regarded as graft loss in this paper. Therefore, 1-year graft survival was 90.2%. Graft survival in cadaveric and live-donor recipients was 90.8% and 88.7%, respectively. As there was no mortality reported among graft recipients, 1-year patient survival rate was 100%. It was found that graft rejection was marginally, but not significantly, higher with female donors. (p=0.05). Conclusion: One-year graft survival in our cohort was comparable with reports from the large centers in the world. Female donor can be a possible negative factor for graft outcome.

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“…Urological complications represent an important cause of morbidity in patients following renal transplantation . However, the evidence available is currently poor, and studies analyzing post‐transplant gender issues have focused on the mismatch of donor/recipient gender . A major finding of our study was that male transplant recipients had a significantly higher incidence of postoperative urinary retention, whereas women experienced UTIs more often.…”

Section: Discussionmentioning

confidence: 72%

“…In the transplant cohort, urological complications such as VUR, UTI, and urinary retention represent potential risk factors for poorer graft outcome . Thus far, studies analyzing post‐transplant gender issues have focused merely on the influence of donor/recipient gender mismatch . Gender‐specific complication rates have not yet been described in post‐transplant patients.…”

Section: Introductionmentioning

confidence: 99%

Gender has no influence on VUR rates after renal transplantation

et al. 2014

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SummaryThe influence of recipient gender on urological complications including vesicoureteral reflux (VUR) after renal transplantation has not yet been established. In this study, post-transplantation voiding cystourethrography and ultrasonography were used to evaluate the upper and lower urinary tract in 598 consecutive renal transplant recipients. Our cohort included 209 females and 389 males, respectively. Gender-specific urological complications and potential confounders were analyzed in relation to long-term allograft outcomes. Postoperative urinary retention occurred more frequently in men (P = 0.004). Urinary tract infections (UTIs) were diagnosed more frequently in women after transplantation (P = 0.05). In a multivariate analysis, gender was not a risk factor for VUR [HR, 1.35 (CI, 0.90-1.96); P = 0.14]. VUR rates were influenced by the surgeon's experience level at the time of transplantation [HR, 0.59 (CI, 0.40-0.87); P = 0.008]. No gender-specific differences were seen for ureteral stenosis, leakage, hydronephrosis, death-censored graft or patient survival, and long-term allograft function. Donor/recipient gender mismatch had no impact on postoperative complication rates. In conclusion, male transplant recipients are at risk for developing postoperative urinary retention, whereas female patients more likely develop UTIs. Surgeon's experience level is a risk factor for developing VUR.

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The effect of donor‐recipient gender mismatch on short‐ and long‐term graft survival in kidney transplantation: a systematic review and meta‐analysis

Abstract: FDMR patients showed poor graft survival. The female recipients had worse short-term graft survival but the best long-term graft survival. This study introduces an important consideration into donor-recipient matching in renal transplantation.

Cited by 36 publications

References 30 publications

Improved renal ischemia tolerance in females influences kidney transplantation outcomes

Improved renal ischemia tolerance in females influences kidney transplantation outcomes

One-year survival rate of renal transplant: factors influencing the outcome

Gender has no influence on VUR rates after renal transplantation

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