Donor myocardial protection using secondary blood cardioplegia during heart transplantation: prospective randomized study in 100 patients

Primary graft dysfunction after heart transplantation: a thorn amongst the roses

“…In a study conducted by the Hamburg group, they noted that the use of a leukocyte depleting filter alongside additional regular antegrade administration of Buckberg cold blood cardioplegia in intervals of 20 min resulted in a reduction of PGD rates [193]. Similar findings were noted by a group from the Czech Republic, utilising continuous cold blood cardioplegia followed by controlled reperfusion of warm blood [194]. The Glasgow group utilised a similar variation with continuous antegrade perfusion in a contemporary cohort of patients, resulting in a significant reduction in PGD rates compared to a historical group of patients and the national UK cohort [195].…”

The role of leukocyte depleting filters in heart transplantation: early outcomes in prospective, randomized clinical trial

“…Fortunately, the mortality was zero in both groups over the first 30 days after Htx, which indicates that myocardial preservation with mere SBC in the Control group is beneficial by itself in this respect. In our previous study, Cerny et al [15] noted the 30-day mortality of 8.2% (4/49) in the patients with SBC.…”

“…In our previous clinical trial we had presented that a technique of secondary blood cardioplegia (SBC) with controlled graft reperfusion is associated with less postoperative myocardial injury and earlier cardiac graft recovery. This technique offers further potential improvement in myocardial protection of cardiac grafts [15].…”