Donepezil, an anti-Alzheimer's disease drug, promotes differentiation and regeneration in injured skeletal muscle through the elevation of the expression of myogenic regulatory factors

Taniguchi, Hiroshi; Arikawa, Mikihiko; Nakatani, Tatsuya; Ichikawa, Atsushi; Sato, Takayuki

doi:10.1016/j.ejphar.2021.174528

Cited by 5 publications

(4 citation statements)

References 37 publications

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“…Donepezil has also been shown to exert adverse effects on muscles, manifested through muscle cramps in patients [80,81]. On the other hand, donepezil promoted muscle differentiation independent of its AchE-inhibitory action in C2C12 mouse myoblast cells in vitro and in a mouse model of a cardiotoxin-based skeletal muscle injury in vivo [82]. In the present study, donepezil tended to decrease the grip strength in NOVX rats compared to the NOVX controls.…”

Section: Discussionsupporting

confidence: 44%

Effects of Donepezil on the Musculoskeletal System in Female Rats

Londzin

Trawczyński

Cegieła

et al. 2023

IJMS

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The extension of human life makes it more and more important to prevent and treat diseases of the elderly, including Alzheimer’s disease (AD) and osteoporosis. Little is known about the effects of drugs used in the treatment of AD on the musculoskeletal system. The aim of the present study was to investigate the effects of donepezil, an acetylcholinesterase inhibitor, on the musculoskeletal system in rats with normal and reduced estrogen levels. The study was carried out on four groups of mature female rats: non-ovariectomized (NOVX) control rats, NOVX rats treated with donepezil, ovariectomized (OVX) control rats and OVX rats treated with donepezil. Donepezil (1 mg/kg p.o.) was administered for four weeks, starting one week after the ovariectomy. The serum concentrations of CTX-I, osteocalcin and other biochemical parameters, bone mass, density, mineralization, histomorphometric parameters and mechanical properties, and skeletal muscle mass and strength were examined. Estrogen deficiency increased bone resorption and formation and worsened cancellous bone mechanical properties and histomorphometric parameters. In NOVX rats, donepezil decreased bone volume to tissue volume ratio in the distal femoral metaphysis, increased the serum phosphorus concentration and tended to decrease skeletal muscle strength. No significant bone effects of donepezil were observed in OVX rats. The results of the present study indicate slightly unfavorable effects of donepezil on the musculoskeletal system in rats with normal estrogen levels.

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Section: Discussionsupporting

confidence: 44%

Effects of Donepezil on the Musculoskeletal System in Female Rats

Londzin

Trawczyński

Cegieła

et al. 2023

IJMS

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“…Delayed mouse skeletal muscle regeneration after injury is due to the inhibition of myoblast differentiation ( Bosma et al, 2012 ; Broskey et al, 2013 ). Known marker genes for chicken muscle regeneration include eMyHC, MyHC , and Desmin ( Gallanti et al, 1992 ; Luo et al, 2021 ; Todaka et al, 2021 ). In this study, we constructed a chicken skeletal muscle injury model using BaCl 2 and found that the overexpression of RRM2 adenovirus suppressed the mRNA expression of the abovementioned muscle regeneration markers and that the protein expression level of Desmin decreased during skeletal muscle regeneration.…”

Section: Discussionmentioning

confidence: 99%

RRM2 promotes the proliferation of chicken myoblasts, inhibits their differentiation and muscle regeneration

Chen,

Zhang,

Niu

et al. 2024

Poultry Science

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“…AChEIs increase acetylcholine levels and promote cholinergic neurotransmission by inhibiting acetylcholinesterase activity, thus acting as a therapeutic agent to improve cognitive dysfunction in AD patients. AChEIs are well tolerated, with mild and transient adverse effects, and are mainly used in the early or intermediate stages of AD [123][124][125].…”

Section: Acetylcholinesterase Inhibitors (Acheis)mentioning

confidence: 99%

Advances in the Study of the Pathology and Treatment of Alzheimer’s Disease and Its Association with Periodontitis

Tang,

Sun,

Yang

et al. 2023

Life

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Alzheimer’s disease (AD) has become one of the leading causes of health problems in the elderly, and studying its causes and treatments remains a serious challenge for researchers worldwide. The two main pathological features of Alzheimer’s disease are the extracellular deposition of β-amyloid (Aβ) to form senile plaques and the intracellular aggregation of hyperphosphorylated Tau protein to form neurofibrillary tangles (NFTs). Researchers have proposed several hypotheses to elucidate the pathogenesis of AD, but due to the complexity of the pathophysiologic factors involved in the development of AD, no effective drugs have been found to stop the progression of the disease. Currently, the mainstay drugs used to treat AD can only alleviate the patient’s symptoms and do not have a therapeutic effect. As researchers explore interactions among diseases, much evidence suggests that there is a close link between periodontitis and AD, and that periodontal pathogenic bacteria can exacerbate Aβ deposition and Tau protein hyperphosphorylation through neuroinflammatory mechanisms, thereby advancing the pathogenesis of AD. This article reviews recent advances in the pathogenesis of AD, available therapeutic agents, the relevance of periodontitis to AD, and mechanisms of action.

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Donepezil, an anti-Alzheimer's disease drug, promotes differentiation and regeneration in injured skeletal muscle through the elevation of the expression of myogenic regulatory factors

Cited by 5 publications

References 37 publications

Effects of Donepezil on the Musculoskeletal System in Female Rats

Effects of Donepezil on the Musculoskeletal System in Female Rats

RRM2 promotes the proliferation of chicken myoblasts, inhibits their differentiation and muscle regeneration

Advances in the Study of the Pathology and Treatment of Alzheimer’s Disease and Its Association with Periodontitis

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