RRM2 promotes the proliferation of chicken myoblasts, inhibits their differentiation and muscle regeneration

Chen, Bingjie; Zhang, Yushi; Niu, Yufang; Wang, Yanxing; Liu, Yang; Ji, Haigang; Han, Ruili; Tian, Yadong; Liu, Xiaojun; Kang, Xiangtao; Li, Zhuanjian

doi:10.1016/j.psj.2023.103407

Poultry Science

2024

DOI: 10.1016/j.psj.2023.103407

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RRM2 promotes the proliferation of chicken myoblasts, inhibits their differentiation and muscle regeneration

Bingjie Chen,

Yushi Zhang,

Yufang Niu

et al.

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High Muscle Expression of IGF2BP1 Gene Promotes Proliferation and Differentiation of Chicken Primary Myoblasts: Results of Transcriptome Analysis

Luo,

Yang,

et al. 2024

Animals

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Muscle development is a multifaceted process influenced by numerous genes and regulatory networks. Currently, the regulatory network of chicken muscle development remains incompletely elucidated, and its molecular genetic mechanisms require further investigation. The Longsheng–Feng chicken, one of the elite local breeds in Guangxi, serves as an excellent resource for the selection and breeding of high–quality broiler chickens. In this study, we conducted transcriptome sequencing of the pectoral muscles of Longsheng–Feng chickens and AA broiler chickens with different growth rates. Through comprehensive bioinformatics analysis, we identified differentially expressed genes that affect muscle growth and showed that IGF2BP1 is a key participant in chicken muscle development. Subsequently, we employed QRT–PCR, EdU staining, and flow cytometry to further investigate the role of IGF2BP1 in the proliferation and differentiation of chicken myogenic cells. We identified 1143 differentially expressed genes, among which IGF2BP1 is intimately related to the muscle development process and is highly expressed in muscle tissues. Overexpression of IGF2BP1 significantly promotes the proliferation and differentiation of chicken primary myoblasts, while knockdown of IGF2BP1 significantly inhibits these processes. In summary, these results provide valuable preliminary insights into the regulatory roles of IGF2BP1 in chicken growth and development.

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High Muscle Expression of IGF2BP1 Gene Promotes Proliferation and Differentiation of Chicken Primary Myoblasts: Results of Transcriptome Analysis

Luo,

Yang,

et al. 2024

Animals

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show abstract

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RRM2 promotes the proliferation of chicken myoblasts, inhibits their differentiation and muscle regeneration

Cited by 1 publication

References 104 publications

High Muscle Expression of IGF2BP1 Gene Promotes Proliferation and Differentiation of Chicken Primary Myoblasts: Results of Transcriptome Analysis

High Muscle Expression of IGF2BP1 Gene Promotes Proliferation and Differentiation of Chicken Primary Myoblasts: Results of Transcriptome Analysis

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