Don’t stop at first glance: pulmonary artery angiosarcoma mimicking chronic thromboembolic pulmonary hypertension

Correale, Michele; Tarantino, Nicola; Ieva, Riccardo; Gravina, Matteo; Casavecchia, Grazia; Strazzella, Caterina; Brunetti, Natale Daniele

doi:10.1177/2045894018785047

Cited by 3 publications

(7 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The flowchart of the patient selection is shown in Figure 4; 19 studies with 21 cases fulfilled these criteria. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] Table 1 summaries the key information in these articles. The mean age of the previously reported patients with pulmonary angiosarcoma was 56.2 years, and in our cases, it was 64 years (range 54-74 years).…”

Section: Discussionmentioning

confidence: 99%

“…22 Acute pulmonary embolism would produce an acute-onset filling defect in the pulmonary vasculature with no thickening of the pulmonary artery wall, and can be identified by a non-contrast-enhancing filling defect. 18 Pulmonary 23 There is no standard treatment regimen for pulmonary artery angiosarcoma. Surgery has been the mainstay for locally confined disease.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Primary pulmonary angiosarcoma: case reports and review of the literature

Virarkar

Tayyab

Thampy

et al. 2019

Asian Cardiovasc Thorac Ann

View full text Add to dashboard Cite

Pulmonary artery angiosarcoma is a rare malignant vascular tumor with an aggressive clinical course and a poor prognosis. Hemoptysis and shortness of breath have been reported as common clinical presentations. The exact clinicopathology is unknown. A tissue specimen obtained by percutaneous fine-needle aspiration cytology or open/thoracoscopic biopsy can confirm the diagnosis based on histopathological and immunohistochemical features. The differential diagnosis includes pulmonary thromboembolism, vascular malformations, and lung carcinoma. There is a paucity of literature describing this tumor, with only a few case reports available. There is also a lack of standardized guidelines for management, which further worsens the survival outcome. We report 3 cases of pulmonary artery angiosarcoma and review the recent literature.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Primary pulmonary angiosarcoma: case reports and review of the literature

Virarkar

Tayyab

Thampy

et al. 2019

Asian Cardiovasc Thorac Ann

View full text Add to dashboard Cite

show abstract

“…Nevertheless, early detection and diagnosis have been reported, allowing for prompt resection of the tumor and increased odds of remission [ 6 , 7 ]. Due to the lack of proper diagnostic criteria, PAS is often misdiagnosed or underdiagnosed, leading to progression of the disease and high mortality [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical Detection of Primary Pulmonary Angiosarcoma

Khalid

Khan

Lomiguen

et al. 2021

Cureus

View full text Add to dashboard Cite

Pulmonary angiosarcomas (PAS) are rare malignant vascular tumors that due to their aggressive and metastatic nature, are often diagnosed at a late stage, resulting in a poorer prognosis. Here we present a 53-year-old male who was initially found to have recurring episodes of dyspnea and syncope, with initial workup showing bilateral saddle pulmonary embolisms on computerized tomography, presumed secondary to newly discovered atrial fibrillation with sinus node dysfunction. Further investigation over subsequent months and subsequent biopsy of a potential lung mass ultimately revealed pulmonary angiosarcoma of the spindle cell line. This case emphasizes findings in the current literature, which reveal the time between the onset of symptoms and definitive diagnosis ranges from two to six months, with a median survival time of seven months or two months, with solitary lesions or multiple lesions at the time of diagnosis, respectively. With the limited incidence of PAS, this case suggests benefits in the development of screening and detection criteria for earlier detection and treatment.

show abstract

“…Even a diagnosis of pulmonary thrombo-embolism exclusively based on echocardiography may be occasionally missed without a careful diagnostic work-up. 2 …”

mentioning

confidence: 99%

“…Even a diagnosis of pulmonary thromboembolism exclusively based on echocardiography may be occasionally missed without a careful diagnostic work-up. 2 After a preliminary screening suspect for pulmonary hypertension and/or chronic thrombo-embolic etiology, the patients should be referred to tertiary centers with specific and multi-professional expertise (heart and thoracic imaging). [3][4][5][6] Fig .…”

mentioning

confidence: 99%