1995
DOI: 10.1016/0165-1218(95)90052-7
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Dominant lethal and heritable translocation tests with chlorambucil and melphalan in male mice

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Cited by 36 publications
(23 citation statements)
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“…There are a lot of studies on genotoxicity of metabolities of ASP (Austin et al, 1992;Brook and Chandley, 1985;Generoso et al, 1995;Sargentini and Smith, 1986). Shephard et al (1991) reported that ASP has a weak mutagenic effect in Ames test after nitrosation.…”
Section: Discussionmentioning
confidence: 99%
“…There are a lot of studies on genotoxicity of metabolities of ASP (Austin et al, 1992;Brook and Chandley, 1985;Generoso et al, 1995;Sargentini and Smith, 1986). Shephard et al (1991) reported that ASP has a weak mutagenic effect in Ames test after nitrosation.…”
Section: Discussionmentioning
confidence: 99%
“…7 It can also induce dominant lethal mutation and heritable translocations in postmeiotic germ cells, particularly in early-mid spermatids. 8 Fludarabine is a purine analogue. However, little is known about it in relation to gonadotoxicity.…”
Section: Discussionmentioning
confidence: 99%
“…When data of individual patients were analysed prior to BMT, only four had LCI with elevated LH levels: three patients (1,6,7) had compensated type (high LH and elevated T levels) and one patient (31) had frank LCI (elevated LH and low T levels). However, another three patients (8,12, 29) had low T with normal LH levels. Post-transplant, only 4/28 had low T levels (8, 21,27,28).…”
Section: Nonmyeloablative Transplantation C Kyriacou Et Almentioning
confidence: 99%
“…[16][17][18] The full mutagenic potential is realised in Salmonella typhimurium after metabolic activation, principally by cytochromes P-450. 19 The induction of micronuclei, sister chromatid exchanges, chromosome aberrations, 20 specific-locus mutations, 21 dominant lethal mutations and inheritable translocations in post-meiotic germ cells in mice 22 observed. In vivo data on melphalan toxicity modification by WR-2721 [23][24][25] prompted us to evaluate the modulating effect of amifostine with different genetic endpoints, in various cellular systems.…”
Section: Introductionmentioning
confidence: 99%