Dominant and Subordinate Relationship Formed by Repeated Social Encounters Alters Gut Microbiota in Greater Long-Tailed Hamsters

Zhao, Jidong; Li, Guoliang; Lü, Wei; Huang, Shu‐Li; Zhang, Zhibin

doi:10.1007/s00248-019-01462-z

Cited by 6 publications

(6 citation statements)

References 71 publications

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“…Second, voles of SD group at week 8 showed a significantly higher attack intensity than voles of LD group, which is consistent with previous studies (e.g., Siberian hamster) [ 14 ], but the underlying mechanisms remain unclear [ 91 ]. Previous studies suggest that aggression may increase serum corticosterone levels [ 38 ] and alter the relative abundance of gut microbiota [ 45 ], which may have an indistinguishable effect with photoperiod on hormone, genes, and gut microbiota. However, we found there was no significant association of number of attacks and attack duration with levels of all hormones and expression of all genes (except for testicular GnRH ) in both SD and LD groups (Table S 10 ), indicating the effect of attack intensity would be minor in our study.…”

Section: Discussionmentioning

confidence: 99%

“…We collected feces of voles in both Experiment 1 and Experiment 2 by placing each of 2 voles in a sterile container (26 × 12 × 12 cm) with a paper under the containers between 08:00 a.m. and 10:00 a.m. on the last day of weeks 2, 4, 6, and 8. Fresh feces were collected from each vole within 10 min with forceps and then stored at −80°C for subsequent analysis [ 45 ]. After sample collection, the voles were returned to their own cages.…”

Section: Methodsmentioning

confidence: 99%

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Gut microbiota is associated with the effect of photoperiod on seasonal breeding in male Brandt’s voles (Lasiopodomys brandtii)

Zhu

Liu

et al. 2022

Microbiome

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Background Seasonal breeding in mammals has been widely recognized to be regulated by photoperiod, but the association of gut microbiota with photoperiodic regulation of seasonal breeding has never been investigated. Results In this study, we investigated the association of gut microbiota with photoperiod-induced reproduction in male Brandt’s voles (Lasiopodomys brandtii) through a long-day and short-day photoperiod manipulation experiment and fecal microbiota transplantation (FMT) experiment. We found photoperiod significantly altered reproductive hormone and gene expression levels, and gut microbiota of voles. Specific gut microbes were significantly associated with the reproductive hormones and genes of voles during photoperiod acclimation. Transplantation of gut microbes into recipient voles induced similar changes in three hormones (melatonin, follicle-stimulating hormone, and luteinizing hormone) and three genes (hypothalamic Kiss-1, testicular Dio3, and Dio2/Dio3 ratio) to those in long-day and short-day photoperiod donor voles and altered circadian rhythm peaks of recipient voles. Conclusions Our study firstly revealed the association of gut microbiota with photoperiodic regulation of seasonal breeding through the HPG axis, melatonin, and Kisspeptin/GPR54 system. Our results may have significant implications for pest control, livestock animal breeding, and human health management.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Gut microbiota is associated with the effect of photoperiod on seasonal breeding in male Brandt’s voles (Lasiopodomys brandtii)

Zhu

Liu

et al. 2022

Microbiome

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“…The discriminating taxa identified by LEfSe were then directly correlated to the behavioral test scores (cage means). With EPM test scores, the abundance of Adlercreutzia (previously linked to depression in humans [ 55 ], and to anxiety and consumption of antidepressant medication in rodents [ 56 , 57 , 58 ]) and of Turicibacter (previously linked to depressive-like behavior in rats [ 59 ]) were significantly associated to increased anxiety-like behavior levels (Spearman’s ρ ‘% of Open Time’: Adlercreutzia , p = 0.002, r = -0.62; Turicibacter , p = 0.004, r = −0.6). In contrast, Mogibacterium and Eubacterium abundance was associated with decreased levels of anxiety-like behavior (Spearman’s ρ ‘% of Open Time’: Mogibacterium , p = 0.01, r = 0.53; Eubacterium , p = 0.03, r = 0.46).…”

Section: Resultsmentioning

confidence: 99%

Specific Changes in the Mammalian Gut Microbiome as a Biomarker for Oxytocin-Induced Behavioral Changes

et al. 2021

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Prolonged exposure to psychiatric pharmacological agents is often associated with marked gastrointestinal phenomena, including changes in food intake, bowel motility, gastric emptying, and transit time. Those changes are reflected in the gut microbiota composition of the patient and can, therefore, be objectively measured. This is in contrast to the standard psychiatric evaluation of patients, which includes symptoms that are subjectively assessed (i.e., mood, anxiety level, perception, thought disorders, etc.). The association between a drug’s effect on the microbiota and psychiatric symptoms may allow for quantifiable surrogate markers of treatment effectiveness. Changes in the levels of specific drug-sensitive bacterial species can, thus, potentially serve as biomarkers for the intake and effectiveness of psychiatric drugs. Here, we show substantial microbiota changes that were associated with oxytocin administration and the decreased anxiety/depression-like behaviors it conferred in a rat model of corticosterone-induced stress. Compared with oxytocin, citalopram produced more minor effects on the rats’ microbiota. Alterations in the gut microbiota may, therefore, reflect the consumption and effectiveness of some psychiatric drugs.

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“…The discriminating taxa identified by LEfSe were then directly correlated to the behavioral test scores (cage means). With EPM test scores, the abundance of Adlercreutzia (previously linked to depression in humans [55], and to anxiety and consumption of antidepressant medication in rodents [56][57][58]) and of Turicibacter (previously linked to depressive-like behavior in rats [59]) were significantly associated to increased anxiety-like behavior levels (Spearman's ρ '% of Open Time': Adlercreutzia, p = 0.002, r = -0.62; Turicibacter, p = 0.004, r = −0.6). In contrast, Mogibacterium and Eubacterium abundance was associated with decreased levels of anxiety-like behavior (Spearman's ρ '% of Open Time': Mogibacterium, p = 0.01, r = 0.53; Eubacterium, p = 0.03, r = 0.46).…”

Section: Changes In Relative Abundance Of Specific Bacterial Taxamentioning

confidence: 99%

Specific Changes in the Mammalian Gut Microbiome as a Biomarker for Oxytocin-Induced Behavioral Changes

et al. 2021

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Dominant and Subordinate Relationship Formed by Repeated Social Encounters Alters Gut Microbiota in Greater Long-Tailed Hamsters

Cited by 6 publications

References 71 publications

Gut microbiota is associated with the effect of photoperiod on seasonal breeding in male Brandt’s voles (Lasiopodomys brandtii)

Gut microbiota is associated with the effect of photoperiod on seasonal breeding in male Brandt’s voles (Lasiopodomys brandtii)

Specific Changes in the Mammalian Gut Microbiome as a Biomarker for Oxytocin-Induced Behavioral Changes

Specific Changes in the Mammalian Gut Microbiome as a Biomarker for Oxytocin-Induced Behavioral Changes

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