Dominance of Δ5-sterols in eight species of the cactaceae

Salt, Thomas A.; Tocker, Joel; Adler, John H.

doi:10.1016/s0031-9422(00)84774-3

Cited by 30 publications

(12 citation statements)

References 12 publications

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“…With these data together with that previously reported [55], it can be inferred that the sterols found most frequently in the Cactaceae family are the typical C29 and C28 compounds, with the common ∆ 5 unsaturations such as β-sitosterol, campesterol or stigmasterol. However, a distinctive feature of some species is the presence of C27 sterols, with ∆ 8 unsaturations, with an extra 6α-hydroxyl group as peniocerol.…”

Section: Sterols From Mexican Columnar Cactaceaesupporting

confidence: 77%

Chemistry, Biological Activities and In Silico Bioprospection of Sterols and Triterpenes from Mexican Columnar Cactaceae

2020

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The Cactaceae family is an important source of triterpenes and sterols. The wide uses of those plants include food, gathering, medicinal, and live fences. Several studies have led to the isolation and characterization of many bioactive compounds. This review is focused on the chemistry and biological properties of sterols and triterpenes isolated mainly from some species with columnar and arborescent growth forms of Mexican Cactaceae. Regarding the biological properties of those compounds, apart from a few cases, their molecular mechanisms displayed are not still fully understand. To contribute to the above, computational chemistry tools have given a boost to traditional methods used in natural products research, allowing a more comprehensive exploration of chemistry and biological activities of isolated compounds and extracts. From this information an in silico bioprospection was carried out. The results suggest that sterols and triterpenoids present in Cactaceae have interesting substitution patterns that allow them to interact with some bio targets related to inflammation, metabolic diseases, and neurodegenerative processes. Thus, they should be considered as attractive leads for the development of drugs for the management of chronic degenerative diseases.

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Section: Sterols From Mexican Columnar Cactaceaesupporting

confidence: 77%

Chemistry, Biological Activities and In Silico Bioprospection of Sterols and Triterpenes from Mexican Columnar Cactaceae

2020

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“…1). Numerous morphological and chemical studies over the past few decades have firmly established the taxonomic position of the Cactaceae in the Caryophyllales (Salt et al, 1987).…”

Section: Resultsmentioning

confidence: 99%

Anti-nociceptive activity of Pereskia bleo Kunth. (Cactaceae) leaves extracts

Wahab

Guilhon

Fernandes

et al. 2012

Journal of Ethnopharmacology

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“…On the other hand, the first extract, at a concentration of 4 µg/mL, was effective against P. citrinum and A. versicolor . The presence of sterols, such as sitosterol [8,11,21], probably determined the ability of such extracts to inhibit the antifungal activity. Phytosterols are reported for their antibacterial and antifungal activities [22].…”

Section: Discussionmentioning

confidence: 99%

Pereskia aculeata Muller (Cactaceae) Leaves: Chemical Composition and Biological Activities

Souza

Caputo

Barros

et al. 2016

IJMS

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The aims of this work were to study the chemical composition of the essential oil from the leaves of Pereskia aculeata and to evaluate some biological activities of three leaf extracts. The phenolic content, antioxidant activity, and in vitro antimicrobial and antifungal activities were determined. The methanol extract showed antioxidant activity (EC50 7.09 mg/mL) and high polyphenols content (15.04 ± 0.31 mg gallic acid equivalents (GAE)/g). The petroleum ether extract exhibited potent antibacterial activity against Escherichia coli, whereas the chloroform extract showed inhibitory activity against Bacillus cereus and Staphylococcus aureus. The petroleum ether and methanol extracts were more effective in inhibiting the growth of Aspergillus versicolor. The possible cytotoxicity of extracts on neuroblastoma SH-SY5Y cancer cell line and the influence on adenylate cyclase (ADCY) expression was also studied. P. aculeata chloroform extract showed antiproliferative activity with an IC50 value of 262.83 µg/mL. Treatments of SH-SY5Y neuroblastoma cells with 100 µg/mL of methanol extract significantly reduced ADCY1 expression.

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Dominance of Δ5-sterols in eight species of the cactaceae

Cited by 30 publications

References 12 publications

Chemistry, Biological Activities and In Silico Bioprospection of Sterols and Triterpenes from Mexican Columnar Cactaceae

Chemistry, Biological Activities and In Silico Bioprospection of Sterols and Triterpenes from Mexican Columnar Cactaceae

Anti-nociceptive activity of Pereskia bleo Kunth. (Cactaceae) leaves extracts

Pereskia aculeata Muller (Cactaceae) Leaves: Chemical Composition and Biological Activities

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