Anti-nociceptive activity of Pereskia bleo Kunth. (Cactaceae) leaves extracts

Wahab, Ikarastika Rahayu Abdul; Guilhon, Carolina Carvalho; Fernandes, Patrícia Dias; Boylan, Fábio

doi:10.1016/j.jep.2012.10.029

Cited by 32 publications

(28 citation statements)

References 24 publications

(24 reference statements)

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“…Intraperitoneally injection of vitexin at a dose of 10 mg/kg produced a significant inhibition (91%) of acetic acid‐induced abdominal constrictions in mice, while vicenin‐2 (6,8‐di‐ C ‐glycosyl apigenin ( 40 )) produced an inhibition of 41% at the same dose . However, some researchers conducted the same model at dose of 10 mg/kg but no efficient effect was observed. In a variety of inflammatory pain models, vitexin showed an analgesic effect by targeting TRPV1 and oxidative stress and by modulating cytokine production …”

Section: Resultsmentioning

confidence: 99%

Natural Flavonoids as Promising Analgesic Candidates: A Systematic Review

Xiao

Wang

Gui

et al. 2016

Chemistry & Biodiversity

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Due to the chemical structural diversity and various analgesic mechanisms, an increasing number of studies indicated that some flavonoids from medicinal plants could be promising candidates for new natural analgesic drugs, which attract high interests of advanced users and academic researchers. The aim of this systematic review is to report flavonoids and its derivatives as new analgesic candidates based on the pharmacological evidences. Sixty-four papers were found concerning the potential analgesic activity of 46 flavonoids. In this case, the evidence for analgesic activity of flavonoids and total flavonoids was investigated. Meanwhile, the corresponding analgesic mechanism of flavonoids was discussed by generalizing and analyzing the current publications. Based on this review, the conclusion can be drawn that some flavonoids are promising candidates for painful conditions and deserve particular attention in further research and development.

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Section: Resultsmentioning

confidence: 99%

Natural Flavonoids as Promising Analgesic Candidates: A Systematic Review

Xiao

Wang

Gui

et al. 2016

Chemistry & Biodiversity

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“…This is followed by investigations of its antimicrobial and antiparasitic effects in vitro [8, 38, 41–43, 52]. The snake venom neutralizing properties [33], antinociceptive effects [35], and toxicity [22, 31] of this plant have been evaluated through in vivo studies.…”

Section: Resultsmentioning

confidence: 99%

“…Wahab et al [35] evaluated the antinociceptive activity of the ethanol extract and its fractions using two in vivo analgesic models: peripheral formalin-induced licking and acetic acid-induced abdominal writhing. They showed that the ethanol extract, hexane fraction, dichloromethane fraction, and ethyl acetate fraction of P. bleo had moderate antinociceptive effects.…”

Section: Resultsmentioning

confidence: 99%

A Review of Botanical Characteristics, Traditional Usage, Chemical Components, Pharmacological Activities, and Safety of Pereskia bleo (Kunth) DC

Zareisedehizadeh

Tan

Koh

2014

Evidence-Based Complementary and Alternative Medicine

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Pereskia bleo, a leafy cactus, is a medicinal plant native to West and South America and distributed in tropical and subtropical areas. It is traditionally used as a dietary vegetable, barrier hedge, water purifier, and insect repellant and for maintaining health, detoxification, prevention of cancer, and/or treatment of cancer, hypertension, diabetes, stomach ache, muscle pain, and inflammatory diseases such as dermatitis and rheumatism. The aim of this paper was to provide an up-to-date and comprehensive review of the botanical characteristics, traditional usage, phytochemistry, pharmacological activities, and safety of P. bleo. A literature search using MEDLINE (via PubMed), Science direct, Scopus and Google scholar and China Academic Journals Full-Text Database (CNKI) and available eBooks and books in the National University of Singapore libraries in English and Chinese was conducted. The following keywords were used: Pereskia bleo, Pereskia panamensis, Pereskia corrugata, Rhodocacus corrugatus, Rhodocacus bleo, Cactus panamensis, Cactus bleo, Spinach cactus, wax rose, Perescia, and Chinese rose. This review revealed the association between the traditional usage of P. bleo and reported pharmacological properties in the literature. Further investigation on the pharmacological properties and phytoconstituents of P. bleo is warranted to further exploit its potentials as a source of novel therapeutic agents or lead compounds.

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“…saboten administration. Extracts and isolated compounds from P. bleo leaf showed antinociceptive activity [28,29]; P. bleo fractions had the isolated sitosterol and vitexin which possessed a central antinociceptive effect [29]. Part of this effect is mediated by opioid receptors and the nitrergic pathway.…”

Section: Discussionmentioning

confidence: 99%

Pereskia aculeata Muller (Cactaceae) Leaves: Chemical Composition and Biological Activities

Souza

Caputo

Barros

et al. 2016

IJMS

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The aims of this work were to study the chemical composition of the essential oil from the leaves of Pereskia aculeata and to evaluate some biological activities of three leaf extracts. The phenolic content, antioxidant activity, and in vitro antimicrobial and antifungal activities were determined. The methanol extract showed antioxidant activity (EC50 7.09 mg/mL) and high polyphenols content (15.04 ± 0.31 mg gallic acid equivalents (GAE)/g). The petroleum ether extract exhibited potent antibacterial activity against Escherichia coli, whereas the chloroform extract showed inhibitory activity against Bacillus cereus and Staphylococcus aureus. The petroleum ether and methanol extracts were more effective in inhibiting the growth of Aspergillus versicolor. The possible cytotoxicity of extracts on neuroblastoma SH-SY5Y cancer cell line and the influence on adenylate cyclase (ADCY) expression was also studied. P. aculeata chloroform extract showed antiproliferative activity with an IC50 value of 262.83 µg/mL. Treatments of SH-SY5Y neuroblastoma cells with 100 µg/mL of methanol extract significantly reduced ADCY1 expression.

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Anti-nociceptive activity of Pereskia bleo Kunth. (Cactaceae) leaves extracts

Cited by 32 publications

References 24 publications

Natural Flavonoids as Promising Analgesic Candidates: A Systematic Review

Natural Flavonoids as Promising Analgesic Candidates: A Systematic Review

A Review of Botanical Characteristics, Traditional Usage, Chemical Components, Pharmacological Activities, and Safety of Pereskia bleo (Kunth) DC

Pereskia aculeata Muller (Cactaceae) Leaves: Chemical Composition and Biological Activities

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