Domiciliary oxygen for interstitial lung disease

Crockett, Alan; Cranston, Josephine M; Antic, Nic

doi:10.1002/14651858.cd002883

Cited by 58 publications

(38 citation statements)

References 4 publications

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“…However, only one study found a significant effect of oxygen on V′O 2 peak and maximum work rate [36]. However, to date no study has examined the long-term effects of oxygen therapy on exercise capacity in patients with ILD and thus it is not known whether there are survival and quality-of-life benefits from oxygen therapy [73]. A number of randomised controlled trials have examined the effects of pharmaceutical treatments on exercise capacity in IPF.…”

Section: The Role Of Cardiopulmonary Exercise Test In Ildsmentioning

confidence: 99%

Exertional dyspnoea in interstitial lung diseases: the clinical utility of cardiopulmonary exercise testing

Bonini

Fiorenzano

2017

Eur Respir Rev

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Interstitial lung diseases (ILDs) represent a heterogeneous group of pathologies characterised by alveolar and interstitial damage, pulmonary inflammation (usually associated with fibrosis), decreased lung function and impaired gas exchange, which can be attributed to either a known or an unknown aetiology. Dyspnoea is one of the most common and disabling symptoms in patients with ILD, significantly impacting quality of life. The mechanisms causing dyspnoea are complex and not yet fully understood. However, it is recognised that dyspnoea occurs when there is an imbalance between the central respiratory efferent drive and the response of the respiratory musculature. The respiratory derangement observed in ILD patients at rest is even more evident during exercise. Pathophysiological mechanisms responsible for exertional dyspnoea and reduced exercise tolerance include altered respiratory mechanics, impaired gas exchange, cardiovascular abnormalities and peripheral muscle dysfunction.This review describes the respiratory physiology of ILD, both at rest and during exercise, and aims to provide comprehensive and updated evidence on the clinical utility of the cardiopulmonary exercise test in the assessment and management of these pathological entities. In addition, the role of exercise training and pulmonary rehabilitation programmes in the ILD population is addressed.

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Section: The Role Of Cardiopulmonary Exercise Test In Ildsmentioning

confidence: 99%

Exertional dyspnoea in interstitial lung diseases: the clinical utility of cardiopulmonary exercise testing

Bonini

Fiorenzano

2017

Eur Respir Rev

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“…However, there is a dearth of studies addressing this question in patients with IPF or with ILD at large. The only randomised controlled trial of LTOT in ILD was aimed at patients with resting hypoxia (37 patients randomised to receive oxygen and 25 no oxygen) and, therefore, with advanced-stage fibrotic ILD, and is unpublished (A. Braghiroli, S. Maugeri Foundation, IRCCS, Veruno, Italy; personal communication) [70]. No difference in survival at 1, 2 and 3 years was observed between the two groups, although the absence of further data makes this finding difficult to interpret.…”

Section: Nocturnal Hypoxia and Supplemental Oxygen In Ipfmentioning

confidence: 99%

Idiopathic pulmonary fibrosis and sleep disorders: no longer strangers in the night

et al. 2015

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The prevalence of obstructive sleep apnoea (OSA) is continuously increasing in patients with idiopathic pulmonary fibrosis (IPF) and, for the first time, the recent IPF guidelines recognise OSA as an important associated comorbidity that can affect patient's survival. Thus, it becomes conceivable that clinicians should refer patients with newly diagnosed IPF to sleep centres for the diagnosis and treatment of OSA as well as for addressing issues regarding the reduced compliance of patients with continuous positive airway pressure therapy. The discovery of biomarkers common to both disorders may help early diagnosis, institution of the most appropriate treatment and follow-up of patients. Better understanding of epigenetic changes may provide useful information about pathogenesis and, possibly, development of new drugs for a dismal disease like IPF. @ERSpublications It is now believed that IPF and sleep disorders can coexist in the same patient

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“…Moreover, the effects of oxygen therapy on HRQOL measures in these conditions have been rarely investigated. 119 …”

Section: Oxygen For Chronic Lung Diseases Other Than Copdmentioning

confidence: 99%

The Story of Oxygen

Heffner

2012

Respir Care

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The history of oxygen from discovery to clinical application for patients with chronic lung disease represents a long and storied journey. Within a relatively short period, early investigators not only discovered oxygen but also recognized its importance to life and its role in respiration. The application of oxygen to chronic lung disease, however, took several centuries. In the modern era, physiologists pursued the chemical nature of oxygen and its physiologic interaction with cellular metabolism and gas transport. It took brazen clinicians, however, to pursue oxygen as a therapeutic resource for patients with chronic lung disease because of the concern in the 20th century of the risks of oxygen toxicity. Application of ambulatory oxygen devices allowed landmark investigations of the long-term effects of continuous oxygen that established its safety and efficacy. Although now well established for hypoxic patients, many questions remain regarding the benefits of oxygen for varying severity and types of chronic lung disease.

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Domiciliary oxygen for interstitial lung disease

Cited by 58 publications

References 4 publications

Exertional dyspnoea in interstitial lung diseases: the clinical utility of cardiopulmonary exercise testing

Exertional dyspnoea in interstitial lung diseases: the clinical utility of cardiopulmonary exercise testing

Idiopathic pulmonary fibrosis and sleep disorders: no longer strangers in the night

The Story of Oxygen

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