Domiciliary oxygen for chronic obstructive pulmonary disease

Crockett, A.J.; Cranston, Josephine M; Moss, J. R.; Alpers, J. H.

doi:10.1002/14651858.cd001744

Cited by 27 publications

(29 citation statements)

References 6 publications

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“…According to current indications, patients with nocturnal desaturation or hypoxaemia induced by exercise should also receive oxygen, even if the resting SP,O 2 is .88%. However, domiciliary oxygen therapy in subjects with Pa,O 2 60-70% or with nocturnal desaturation did not increase survival [19,20] and, therefore, is a secondary priority for home oxygen services.…”

Section: Discussionmentioning

confidence: 86%

Prevalence of oxygen desaturation and use of oxygen at home in adults at sea level and at moderate altitude

Pérez‐Padilla

Torre-Bouscoulet²,

Muiño³

et al. 2006

European Respiratory Journal

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, on behalf of the Proyecto Latinoamericano de Investigacion en Obstruccion Pulmonar (PLATINO) group ABSTRACT: The aim of this study was to determine the prevalence of oxygen desaturation in adults aged o40 yrs as altitude above sea level increases.A population-based, cross-sectional study with a multistage cluster sampling of 1,063 subjects from metropolitan Mexico City (Mexico; 2,240 m above sea level), 1,357 from Caracas (Venezuela; 950 m) and 943 from Montevideo (Uruguay; 35 m). The mean of six measurements of arterial oxygen saturation (SP,O 2 ) was estimated using a pulse oximeter.Mean SP,O 2 decreased with altitude. No subject from Montevideo had a mean SP,O 2 f88%. Prevalence of subjects with SP,O 2 f88%, a common criterion used for oxygen prescription, was 1.0% in Caracas and 6.0% in Mexico City. Additional predicting factors for hypoxaemia in multiple regression models were age, body mass index and a low forced expiratory volume in one second as a percentage of the predicted value. In Mexico City and Caracas, ,10% of the hypoxaemic subjects reported use of domiciliary oxygen, whereas at least half of the subjects reporting use of oxygen at home had a resting SP,O 2 .88%.In conclusion, the prevalence of hypoxaemia was closely related to altitude. Priorities for oxygen prescription must be defined in moderate altitudes because it is unfeasible to provide it to all subjects fulfilling the criteria commonly used.

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Section: Discussionmentioning

confidence: 86%

Prevalence of oxygen desaturation and use of oxygen at home in adults at sea level and at moderate altitude

Pérez‐Padilla

Torre-Bouscoulet²,

Muiño³

et al. 2006

European Respiratory Journal

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“…Current recommendations for oxygen prescription for air travel are derived from the positive effects of oxygen supplementation on right heart function, respiratory muscle function and survival in patients with chronic hypoxaemia [14]. These effects rely, however, on long-term oxygen application for o15 h?day -1 .…”

Section: Discussionmentioning

confidence: 99%

Lung function in adults with cystic fibrosis at altitude: impact on air travel

Fischer

Sm²,

K³

et al. 2005

European Respiratory Journal

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Current guidelines for air travel state that patients with chronic respiratory diseases are required to use oxygen if their in-flight arterial oxygen tensions (Pa,O 2 ) drop below 6.6 kPa. This recommendation may not be strictly applicable to cystic fibrosis patients, who may tolerate lower Pa,O 2 for several hours without clinical symptoms.Lung function, symptoms, blood gas levels and signs of pulmonary hypertension were studied in 36 cystic fibrosis patients at altitudes of 530 m and, after 7 h, 2,650 m. A hypoxia inhalation test (inspiratory oxygen fraction 0.15) was performed at low altitude in order to predict high-altitude hypoxaemia.Median Pa,O 2 dropped from 9.8 kPa at low altitude to 7.0 kPa at high altitude. Mild exercise at a workload of 30 W further decreased Pa,O 2 . Two-thirds of all patients exhibited Pa,O 2 of ,6.6 kPa during exercise and, except for one patient, were asymptomatic. Patients were significantly less obstructed at an altitude of 2,650 m. Low forced expiratory volume in one second at baseline was associated with a low Pa,O 2 at altitude.It is concluded that cystic fibrosis patients with baseline arterial oxygen tensions of .8.0 kPa safely tolerate an altitude of 2,650 m for several hours under resting conditions. The risk assessment of low in-flight oxygenation should encompass the whole clinical situation of cystic fibrosis patients, with special attention being paid to the presence of severe airway obstruction.

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“…In adult COPD models, LTOT is known to decrease mortality in patients with severe hypoxaemia, 66 67 but in patients with night-time hypoxia only, no significant survival improvements were noted. 68 Further work in CF is required to answer the questions of when to start oxygen, how much oxygen should be given, and for how long.…”

Section: Unanswered Questions About Oxygen Therapy In Cfmentioning

confidence: 99%