Assessment of hypoxia in children with cystic fibrosis

Urquhart, Donald; Montgomery, Hugh; Jaffé, Adam

doi:10.1136/adc.2005.071795

Cited by 43 publications

(37 citation statements)

References 63 publications

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“…The role of oxygen supplementation in improvement of submaximal exercise capacity among adults with CF has been documented, but further investigations are necessary to completely understand the influence of oxygen supplementation during exercise in children. 35,36 Similar values of BMI within groups in our study showed their comparability in nutritional status. Our data showed that BMI was negatively correlated with W peak , but that the correlation was not significant.…”

Section: Discussionmentioning

confidence: 49%

Static Hyperinflation Is Associated With Decreased Peak Exercise Performance in Children With Cystic Fibrosis

et al. 2013

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BACKGROUND:We evaluated the exercise capacity of children with cystic fibrosis to determine whether ventilatory limitation associated with static hyperinflation is related with decreased exercise capacity, thus predisposing these children to arterial hypoxemia during progressive exercise. METHODS: Thirty-seven children, ages 8 -17 years, underwent spirometry, body plethysmography, and cardiopulmonary exercise testing after arterial catheter placement. According to the ratio of residual volume to total lung capacity (RV/TLC), the subjects were categorized as either with (RV/TLC > 30%) or without static hyperinflation (RV/TLC < 30%). RESULTS: Children with static hyperinflation showed lower values of maximum load per kilogram (% predicted) (P ‫؍‬ .01), which was aggravated by ventilatory limitation (FEV 1 < 80% of predicted, peak oxygen consumption [% predicted] < 85%, and breathing reserve index > 0.7). Subjects with ventilatory limitation had significantly lower oxygen saturation (P ‫؍‬ .04) and hypoxemia (P ‫؍‬ .03) than did subjects without ventilatory limitation. CONCLUSIONS: In children with cystic fibrosis, static hyperinflation and ventilatory limitation are associated with decrease in exercise performance, oxygen saturation, and P aO 2 during maximum cardiopulmonary exercise testing. All children with cystic fibrosis who exhibit static hyperinflation and ventilatory limitation may require S aO 2 monitoring during progressive exercise.

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Section: Discussionmentioning

confidence: 49%

Static Hyperinflation Is Associated With Decreased Peak Exercise Performance in Children With Cystic Fibrosis

et al. 2013

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“…However, it must be acknowledged that the definition of what constitutes nocturnal oxyhaemoglobin desaturation will vary from country to country and centre to centre due to the lack of evidence supporting cutoffs for treatment and clinical significance. Whether nocturnal oxyhaemoglobin desaturation carries any clinical significance in CF patients at any level has been the subject of controversy [25]. Given the limited trial data supporting nocturnal oxygen therapy in CF, the current study investigated whether a threshold for nocturnal oxyhaemoglobin desaturation existed that was associated with clinical deterioration.…”

Section: Discussionmentioning

confidence: 99%

The impact of nocturnal oxygen desaturation on quality of life in cystic fibrosis

Young

Wilson

Kotsimbos

et al. 2011

Journal of Cystic Fibrosis

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“…23 Um estudo realizado no Brasil 2 revelou a FQ como principal indicação para OLD. Contudo, não está definida a altura ideal para iniciar OLD, não existindo orientações quanto ao rastreio de hipoxemia noturna.…”

Section: Síndromes Polimalformativasunclassified

Oxigenoterapia Domiciliária de Longa Duração na Criança: Evidências e Questões em Aberto

et al. 2014

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Introduction: Long-term home oxygen therapy is indicated for patients with chronic hypoxemia. We intend to describe pediatric population on long-term home oxygen therapy followed-up at Pediatric Respiratory Unit of a tertiary care hospital between 2003-2012 and to compare with previous 1991-2000 review; to verify conformity with international and national recommendations and need for specific pediatric national guidelines, non-existent in Portugal. Material and Methods: Retrospective, descriptive and comparative study based on clinical files review. Review the guidelines for oxygen therapy in pediatric population. Results: We studied 86 patients (59.3% males). The median age at the beginning of oxygen therapy was 0.0 (0.0-216.0) months, with a median duration of 15.0 (3.0-223.0) months. The most frequent diagnosis was bronchopulmonary dysplasia (53.5%), followed by bronchiolitis obliterans (14.0%), neurologic disorders (10.5%), cystic fibrosis (8.1%), miscellaneous syndromes (5.8%), sickle-cell disease (3.5%), other neonatal lung diseases (2.3%) and interstitial lung diseases (2.3%). Are maintained on follow-up 53 (61.6%) patients, 38 on oxygen therapy; 12 (13.9%) died. The median time of follow-up was 39.5 (1.0-246.0) months, minim on other neonatal lung diseases and maximum on cystic fibrosis. Comparing with previous review, this shows a relative increase in bronchiolitis obliterans and bronchopulmonary dysplasia patients, with increased duration in the latter, and inclusion of neurologic and hematologic patients. Discussion: Prescription of long-term oxygen therapy in pediatric age mainly occurs in specific diseases of infants and pre-school aged. Neurologic and hematologic patients represent new indications, similarly to international publications. Conclusion: The knowledge of national reality and pediatric orientations are needed for care plans and rational prescription. Keywords: Child; Long-Term Care; Respiratory Insufficiency; Oxygen Inhalation Therapy; Portugal.

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Assessment of hypoxia in children with cystic fibrosis

Cited by 43 publications

References 63 publications

Static Hyperinflation Is Associated With Decreased Peak Exercise Performance in Children With Cystic Fibrosis

Static Hyperinflation Is Associated With Decreased Peak Exercise Performance in Children With Cystic Fibrosis

The impact of nocturnal oxygen desaturation on quality of life in cystic fibrosis

Oxigenoterapia Domiciliária de Longa Duração na Criança: Evidências e Questões em Aberto

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