Domestic smoke exposure is associated with alveolar macrophage particulate load

Fullerton, Duncan; Jere, Khuzwayo C.; Jambo, Kondwani; Kulkarni, Neeta; Zijlstra, Eduard E.; Grigg, Jonathan; French, Neil; Molyneux, Malcolm E.; Gordon, Stephen B.

doi:10.1111/j.1365-3156.2009.02230.x

Cited by 38 publications

(36 citation statements)

References 23 publications

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“…First, in rats there is a strong association between AM carbon and long-term inhaled BC dose [12]. Secondly, in Malawian adults we found that AM carbon tracks closely with the BC-generating potential of the fuel regularly used in the home for cooking [30]. Thirdly, the lifespan of AM in the lower airway, and therefore its ability to acquire inhaled BC, is up to several months [31].…”

Section: Discussionmentioning

confidence: 75%

Cycling to work in London and inhaled dose of black carbon

et al. 2012

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Modelling studies suggest that urban cycling is associated with an increased inhaled dose of fossil fuel-derived black carbon (BC). Using the amount of black material in airway macrophages as a marker of long-term inhaled BC, we sought to compare inhaled BC dose in London (UK) cyclists and non-cyclists.Airway macrophage carbon was assessed in 28 (58%) out of 48 healthy adults (14 cyclists and 14 non-cyclists) who attended for induced sputum. Short-term (24 h) exposure to BC was assessed on a representative working day in 27 out of 28 subjects. Serum interleukin (IL)-1b, IL-2, IL-6, IL-8, granulocyte-macrophage colony-stimulating factor and tumour necrosis factor (TNF)-a were assessed in 26 out of the 28 subjects.Cyclists were found to have increased airway macrophage carbon when compared with noncyclists (mean¡SE 1.81¡0.21 versus 1.11¡0.07 mm 2 ; p,0.01). Short-term monitoring showed no difference in 24 h BC exposure between the two groups. However, cyclists were exposed to higher concentrations of BC during commuting (p,0.01). Airway macrophage carbon was associated with monitored commute BC (n528; r50.47, p,0.05). TNF-a was found to be increased in cyclists (p,0.05), but no other cytokines were increased. Commuting to work by bicycle in London is associated with increased long-term inhaled dose of BC. Whether cycling per se increases inhaled BC dose remains unclear.

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Section: Discussionmentioning

confidence: 75%

Cycling to work in London and inhaled dose of black carbon

et al. 2012

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“…9 Lam (2013) found the gap between lighting and cooking to be smaller than this. Fullerton et al (2009) found higher levels of particulate matter associated with macrophage cells in people living with kerosene lamps, particularly simple wick-based lamps but also with hurricane lanterns and candles, which have particularly incomplete combustion.…”

Section: Indoor Air Pollutionmentioning

confidence: 95%

Identifying and reducing the health and safety impacts of fuel-based lighting

Mills

2016

Energy for Sustainable Development

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The inequity of costly and low-quality fuel-based lighting is compounded by adverse health and safety risks including burns, indoor air pollution, poisoning due to accidental ingestion of kerosene fuel by children, compromised visual health, maternal health issues, and reduced service in health facilities illuminated solely or sporadically with fuel-based lighting. This article compiles and synthesizes information on the health and safety impacts of fuel-based lighting from 135 reports spanning 33 countries. Energy efficient, off-grid lighting solutions offer the most promising and scalable means to eliminate adverse health outcomes, while lowering lighting costs and reducing greenhouse-gas emissions. Deployments seeking the greatest possible health benefit should target the most impacted geographical and demographic user groups. Because women and children are disproportionately impacted, improved lighting technologies for use by these groups will yield particularly significant health benefits.

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“…45 One of the most important roles of macrophages in the lungs of smokers is clearing the particles entered the lungs through tobacco smoking. 46 In this regard, it is of interest to assess the effects of tobacco smoke on phagocytic capacity of macrophages. Accordingly, macrophages isolated from the lungs of smoke-exposed mice were found to have decreased capacity to bind and internalize yeasts.…”

Section: Discussionmentioning

confidence: 99%

Reduced phagocytic capacity of blood monocyte/macrophages in tuberculosis patients is further reduced by smoking

Aryanpur

Mortaz

Masjedi

et al. 2016

6.3 Tobacco, Smoking Control and Health Education

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Tuberculosis (TB) and tobacco use are two major alarming global health issues posing immense threats to human populations. Mycobacterium tuberculosis (MTB) by activation of macrophages could induce the sequences of cells activation and releases of inflammatory cytokines such as CXCL-8, Il-12 and TNF-α which in turn induces the immune system network. However no information is available on other activity of cells by MTB and smoking. In the current study we aimed to investigate the serum levels TNF-, CXCL-8 and phagocytosis capacity in tuberculosis patients with and without smoking.103 subjects entered the study including 61 new diagnosed pulmonary TB patients (23 smokers and 38 nonsmokers) and 42 control healthy subjects. The phagocytosis of fluorescein isothiocyanate dextran (FITCdextran) in blood monocytes/macrophages through flowcytometry was assessed. Serum levels of TNF- and CXCL-8 were analyzed by ELISA methods.A lower percentage of cells from TB patients who smoked [50.29% (43.4-57.2), p<0.01] took up FITCdextran after 2h compared to non-smoking TB subjects [71.62% (69.2-74.1)] and healthy cases [97.45% (95.9-99.1). Phagocytic capacity was inversely correlated with cigarette smoking as measured by pack years (r=-0.73, p<0.001). The serum levels of TNF- and CXCL-8 were significantly higher in the TB patients who smoked compared to the TB non-smoker group (p<0.001, p<0.01 respectively).Blood monocytes/macrophages from TB patients have reduced phagocytic capacity which is further reduced in TB patients who smoke. Smoking enhanced serum levels of TNF- and CXCL-8 suggesting a greater imbalance between the proinflammatory and anti-inflammatory factors in these patients.

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Domestic smoke exposure is associated with alveolar macrophage particulate load

Cited by 38 publications

References 23 publications

Cycling to work in London and inhaled dose of black carbon

Cycling to work in London and inhaled dose of black carbon

Identifying and reducing the health and safety impacts of fuel-based lighting

Reduced phagocytic capacity of blood monocyte/macrophages in tuberculosis patients is further reduced by smoking

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