Domestic exposure to formaldehyde significantly increases the risk of asthma in young children

Rumchev, Krassi; Spickett, Jeffery; Bulsara, Mahesh; Phillips, Michael; Stick, Stephen M.

doi:10.1183/09031936.02.00245002

Cited by 270 publications

(192 citation statements)

References 24 publications

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“…It has also been reported to lead to shortness of breath, asthmatic symptoms and skin eruptions at concentrations over 0.1 ppm in some people (Krzyzanowski et al 1990;Norback et al 1995;Rumchev et al 2002). International Agency for on Cancer (IARC) has classified formaldehyde as Group 2A carcinogen.…”

mentioning

confidence: 99%

Determination of Formaldehyde Levels in 100 Furniture Workshops in Ankara

Vaizoğlu

Aycan

Akın

et al. 2005

Tohoku J. Exp. Med.

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mentioning

confidence: 99%

Determination of Formaldehyde Levels in 100 Furniture Workshops in Ankara

Vaizoğlu

Aycan

Akın

et al. 2005

Tohoku J. Exp. Med.

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“…Ambient levels of VOCs, including formaldehyde, have been linked to reported asthma in children (Krzyzanowski et al, 1990;Ware et al, 1993;Garrett et al, 1999;Rumchev et al, 2000Rumchev et al, , 2002. The weight of evidence currently available linking VOCs to ill-health in adults suggests that ambient levels found in homes are unlikely to cause adverse effects, but research focusing on the impact of VOCs on the respiratory health of children is sparse.…”

Section: ) Indoor Airmentioning

confidence: 99%

Expressing urine from a gel disposable diaper for biomonitoring using phthalates as an example

Liu

Xia

Guo

et al. 2012

J Expo Sci Environ Epidemiol

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The urinary metabolites of phthalates are well-accepted exposure biomarkers for adults and children older than 6 years but are not commonly used for infants owing to non-convenient sampling. In the light of this situation, a novel sampling method based on monitoring the urine expressed from the gel diaper was developed. The urine was expressed from the gel absorbent after mixing the absorbent with CaCl2 and then collected by a laboratory-made device; the urinary phthalate metabolites were extracted and cleaned using a solid-phase extraction (SPE) column and analyzed with high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry / mass spectrometry. To evaluate the method's feasibility, the following factors were investigated: the proportion of CaCl2 to gel absorbent, the urination volume variation and the target compounds' deposition bias in the diaper, the matrix blank of the different diaper brands, the storage stabilities and the recoveries of creatinine and phthalate metabolites in the expressed urine. Mono-methyl phthalate, mono-ethyl phthalate, mono-butyl phthalate, mono-benzyl phthalate, mono-2-ethylhexyl phthalate and mono-2-ethyl-5-oxohexyl phthalate were involved. 70-80% of the urine can be expressed from the diaper, and the expressed spiking recoveries and the limit of detection of mono-phthalates ranged from 88.5-115% and 0.21-0.50 ng/ml. The method was applied to measure phthalate metabolites in 65 gel diaper samples from 15 infants, and the pilot data suggests the infants are commonly exposed to phthalates. In summary, the method for monitoring of infant exposure to phthalates is sound and validated, and the potential health effects from the vulnerable infants' exposure to phthalates should be concerned.39th Scientific Research Foundation for the Returned Overseas Chinese Scholars (SRF for ROCS); Hundred Talent Program of Chinese Academy of Sciences (CAS); CAS/SAFEA International Partnership Program for Creative Research Teams [KZCX2-YW-T08

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“…There is also potential for vehicle exhaust to be a contributor to in-cabin concentrations of formaldehyde (Yoshida & Matsunga 2005 A similar study was undertaken by Rumchev et al (2002) which monitored 192…”

Section: Sourcesmentioning

confidence: 99%

“…Rumchev et al (2002) reported mean concentrations of 24.5ppb in bedrooms and 22.4ppb in the living room. This study reported a significant relationship between indoor air concentrations and season, indoor air temperature, the presence of unflued gas heaters and new carpets (Rumchev et al 2002).…”

Section: Sourcesmentioning

confidence: 99%

“…As formaldehyde is predominantly an indoor air quality issue, the NEPM does not target this key area of concern. Furthermore, there is limited research or monitoring within Australia for formaldehyde exposure, particularly in relation to children, who are particularly vulnerable to the health impacts associated with exposure (Garrett et all999; Rumchev et al 2002).…”

Section: Introductionmentioning

confidence: 99%

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