Dome‐type carcinoma of the colon

Gut-associated Lymphoid Tissue (GALT) Carcinoma in Ulcerative Colitis

“…The first colonic GALT carcinoma in a patient with UC was reported in 1984 (13). Since then, three additional cases of GALT carcinoma in patients with UC have been published (14)(15)(16). Notably, three out of the four UC-GALT carcinomas were covered by conventional adenomas or high-grade dysplasia, strongly suggesting that non-invasive conventional neoplasias might precede GALT carcinoma in UC.…”

“…This histological characteristic fulfilled the criteria of colonic GALT carcinoma (13). Since then, three additional cases of GALT carcinomas evolving in UC have been reported (14)(15)(16).…”

Dome-type carcinoma of the colon; a rare variant of adenocarcinoma resembling a submucosal tumor: a case report

“…Because of the intimate relationship between the malignant epithelium and lymphoid tissue, they suggested that the tumor might be arising from the dome epithelium overlying gut-associated lymphoid tissue. After similar tumors were reported, the term DC was established [3-8]. …”

“…All but one previously reported DCs were early cancers limited to the submucosal layer [3]. It has been suggested that advanced DC is rare because DC might eventually progress to usual-type adenocarcinoma [7].…”

“…Since Jass et al [1,2] reported this lesion as a distinct variant of adenocarcinoma, less than 10 cases have been reported and most of them are early lesions limited to the submucosal layer [3,4]. Based on the phenotypical features of DCs, including the intimate association with lymphoid tissue, the presence of intraepithelial B-lymphocytes and the lack of goblet cells, DC has been suggested to derive from M-cells of the gut-associated lymphoid tissue [1].…”