Gut-associated Lymphoid Tissue (GALT) Carcinoma in Ulcerative Colitis

Rubio, Carlos A.; Petris, Giovanni De; Puppa, Giacomo

doi:10.21873/anticanres.12303

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…Most cases of GALT/dome-type carcinoma are detected incidentally and are reported either as sporadic-type colon cancer or in association with UC[16,17], familial adenomatous polyposis (FAP)[15], LS[2] and other positive family histories of colorectal cancer (CRC), although it is thought that GALT/dome-type carcinoma is not associated with any specific mechanisms of tumor predisposition[18]. GALT/dome-type carcinomas have been identified in both the right and left colon.…”

Section: Discussionmentioning

confidence: 99%

Gut-associated lymphoid tissue or so-called “dome” carcinoma of the colon: Review

McCarthy

Chetty

2019

WJGO

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AIM To present a comprehensive review of the etiology, clinical features, macroscopic and pathological findings, and clinical significance of Gut-associated lymphoid tissue or “dome” carcinoma of the colon. METHODS The English language medical literature on gut- or gastrointestinal-associated lymphoid tissue (GALT) or “dome” carcinoma of the colon was searched and appraised. RESULTS GALT/dome-type carcinomas of the colon are thought to arise from the M-cells of the lymphoglandular complex of the intestine. They are typically asymptomatic and have a characteristic endoscopic plaque- or “dome”-like appearance. Although the histology of GALT/dome-type carcinomas displays some variability, they are characterized by submucosal localization, a prominent lymphoid infiltrate with germinal center formation, tumor-infiltrating lymphocytes, absence of desmoplasia, and dilated glands lined by columnar epithelial cells with bland nuclear features and cytoplasmic eosinophilia. None of the patients reported in the literature with follow-up have developed metastatic disease or local recurrence. CONCLUSION Increased awareness amongst histopathologists of this variant of colorectal adenocarcinoma is likely to lead to the recognition of more cases.

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Section: Discussionmentioning

confidence: 99%

Gut-associated lymphoid tissue or so-called “dome” carcinoma of the colon: Review

McCarthy

Chetty

2019

WJGO

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“…Whereas telomere shortening was shown to be actively involved in UC development, telomere activators also reduced the expression of common senescence pathways such as p53, and also improved the crypt structure [ 60 ]. Recently, rare cases were reported of carcinoma formation in the GALT in the colons of patients with UC [ 61 ]. Although GALT is relatively scarce in the colon, these areas still carry a risk of oncogenic development, which requires further research [ 61 ].…”

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

“…Recently, rare cases were reported of carcinoma formation in the GALT in the colons of patients with UC [ 61 ]. Although GALT is relatively scarce in the colon, these areas still carry a risk of oncogenic development, which requires further research [ 61 ].…”

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

Cellular Senescence, Inflammation, and Cancer in the Gastrointestinal Tract

Choi

Taheri

Chandra

et al. 2023

IJMS

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Due to modern medical advancements, greater proportions of the population will continue to age with longer life spans. Increased life span, however, does not always correlate with improved health span, and may result in an increase in aging-related diseases and disorders. These diseases are often attributed to cellular senescence, in which cells become disengaged from the cell cycle and inert to cell death. These cells are characterized by a proinflammatory secretome. The proinflammatory senescence-associated secretory phenotype, although part of a natural function intended to prevent further DNA damage, creates a microenvironment suited to tumor progression. This microenvironment is most evident in the gastrointestinal tract (GI), where a combination of bacterial infections, senescent cells, and inflammatory proteins can lead to oncogenesis. Thus, it is important to find potential senescence biomarkers as targets of novel therapies for GI diseases and disorders including cancers. However, finding therapeutic targets in the GI microenvironment to reduce the risk of GI tumor onset may also be of value. This review summarizes the effects of cellular senescence on GI aging, inflammation, and cancers, and aims to improve our understanding of these processes with a goal of enhancing future therapy.

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Colorectal epithelial neoplasm associated with gut-associated lymphoid tissue

Jeon¹,

Ahn²,

Chang³

2020

J Pathol Transl Med

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The gut-associated lymphoid tissue (GALT) system consists of scattered lymphoid cells in the lamina propria and organized lymphoid aggregates or follicles in the mucosa or submucosa [1-5]. GALT serves as part of both the immune system and the mucosal repair system of the gastrointestinal tract [1,6]. The association between GALT and various colorectal pathologic conditions-from inflammatory bowel disease to benign and malignant neoplasms-has been discussed [7-10]. Colorectal epithelial neoplasms located in the submucosa and surrounded by GALT may be encountered in daily practice and occasionally cause difficulties in differential diagnosis. The term "GALT carcinoma" has been suggested as a distinct malignancy arising from the GALT mucosal domain and representing the "third pathway of colorectal carcinogenesis". However, GALT carcinoma is not recognized as a distinct histologic subtype in current colorectal cancer classifications [2,11-28]. A few studies have suggested GALT-associated pseudoinvasion/epithelial misplacement (PEM) as a consideration in the differential diagnosis of GALT-associated tumors [11,12]. However, there are few studies in the Korean literature clarifying the pathologic nature of colorectal epithelial neoplasms located in submucosal GALT. Herein, we investigated the clinicopathologic characteristics of colorectal epithelial neoplasms associated with submucosal GALT. MATERIALS AND METHODS Case selection Eleven cases of colorectal epithelial neoplasm, involving submucosal GALT, identified after endoscopic submucosal dissection, were studied from the pathologic archives of Kosin University Gospel Hospital (Busan, Korea), over a 7-year period from January 2012 to December 2018.

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Gut-associated Lymphoid Tissue (GALT) Carcinoma in Ulcerative Colitis

Abstract: Abstract. Background: In ulcerative colitis (UC), the majority of colorectal carcinomas (CRC) arise in the vast

Cited by 3 publications

References 11 publications

Gut-associated lymphoid tissue or so-called “dome” carcinoma of the colon: Review

Gut-associated lymphoid tissue or so-called “dome” carcinoma of the colon: Review

Cellular Senescence, Inflammation, and Cancer in the Gastrointestinal Tract

Colorectal epithelial neoplasm associated with gut-associated lymphoid tissue

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