Dolichoectatic basilar artery: a review of 23 cases.

Nishizaki, Tomoyuki; Tamaki, N; Takeda, Norio; Shirakuni, Takayuki; Kondoh, Toshiki; Matsumoto, Shirabe

doi:10.1161/01.str.17.6.1277

Cited by 117 publications

(97 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…One patient demonstrated basilar artery ectasy on CT scan and cerebral angiography, as described by others. 7,8 Female carriers In the 10 female carriers, symptoms were much milder, a finding confirmed by others. 9 None of them suffered from renal failure, severe cardiac disease or had experienced a stroke.…”

Section: Clinical Manifestations Of Male Patientssupporting

confidence: 73%

Remarkable variability in renal disease in a large Slovenian family with Fabry disease

et al. 2004

View full text Add to dashboard Cite

Following the diagnosis of Fabry disease in a 45-year-old male, in 31 family members a-galactosidase A (a-Gal) activity in leucocytes was measured and mutation analysis of the a-Gal gene was performed. In the proband, the unique mutation A10523G/N272S in exon 6 was found, which was subsequently detected in seven males (of which one twin) and 10 female subjects. All males showed decreased to absent a-Gal A activity in leucocytes, but three out of 10 female subjects had a-Gal A activities within normal range. Although all male patients had symptoms of classical Fabry disease, such as acroparesthesias, hypohydrosis and heat-intolerance, there was considerable variability in organ involvement, especially in deterioration of renal function. Detailed studies of large families with Fabry disease may give insight into factors that influence the phenotype of this disorder.

show abstract

Section: Clinical Manifestations Of Male Patientssupporting

confidence: 73%

Remarkable variability in renal disease in a large Slovenian family with Fabry disease

et al. 2004

View full text Add to dashboard Cite

show abstract

“…Hemorrhage, either due to rupture of the vertebrobasilar fusiform aneurysm or as a complication of anticoagulation, was not seen at all in our study; neither was it reported in the series of Yu et al 9 or Nishizaki et al 5 Whenever hemorrhage was seen in those patients, a separate cause, such as concomitant saccular aneurysm, carotid fusiform aneurysm, or uncontrolled hypertension, was evident.…”

contrasting

confidence: 71%

“…Those patients with compressive symptoms went on to develop brainstem ischemia or a progressive mass effect due to the fusiform aneurysm. Nishizaki et al 5 suggested the use of antiplatelet therapy in all patients with vertebrobasilar fusiform aneurysm, even those without ischemic symptoms. No follow-up of their patients is available.…”

mentioning

confidence: 99%

Fusiform aneurysm of the vertebrobasilar arterial system.

Echiverri¹,

Rubino²,

Gupta³

et al. 1989

Stroke

125

View full text Add to dashboard Cite

We retrospectively evaluated the clinical features and therapeutic outcomes in 13 consecutive patients with the diagnosis of fusiform aneurysm of the vertebrobasilar system. Four patients (31%) presented with compressive symptoms and 10 (77%) with ischemic symptoms; one patient presented with both types of symptoms. No patient presented with rupture of the fusiform aneurysm. Based on the attending physician's choice, treatment included antiplatelet therapy in five patients, anticoagulation in seven, and no medication in one. Five patients died, four treated with antiplatelet agents and one not treated with any medication. The cause of death was progressive brainstem ischemia in three, sepsis in one, and gastrointestinal bleeding in one patient. All seven patients who received anticoagulants were alive, with no recurrence of symptoms or hemorrhagic complications after a mean follow-up period of 18 months. Based on previous and current series, we conclude that rupture of fusiform aneurysms is rare. Our results suggest a more favorable outcome in the management of these aneurysms with anticoagulation therapy to prevent progressive thrombosis and embolization.

show abstract

“…[7][8][9][10][11][12][13] However, pathological changes in the arterial wall, consisting primarily in defects in the internal elastic lamina with thinning of the media secondary to smooth muscle atrophy, 14 -16 may predispose patients to intracranial bleeding of various kinds. Knowledge of hemorrhagic stroke as a clinical feature of VBD has come from case reports involving a small number of patients.…”

mentioning

confidence: 99%

Intracranial Bleeding in Patients With Vertebrobasilar Dolichoectasia

Passero

Calchetti

Bartalini

2005

Stroke

View full text Add to dashboard Cite

Background and Purpose-Intracranial bleeding in patients with vertebrobasilar dolichoectasia (VBD) is considered uncommon, but there are no precise data to support this opinion. The purpose of this study was to examine the incidence and characteristics of intracranial hemorrhage in patients with VBD and to evaluate factors that may promote bleeding. Methods-We conducted a prospective study of 156 consecutive VDB patients followed-up for an average 9.35 years. The association of demographic, clinical, and imaging features with occurrence of intracranial bleeding was evaluated by multivariate analysis. Survival analysis was used to evaluate rates of incidence. Results-32 hemorrhagic strokes were observed in 28 patients either as a diagnostic event (nϭ10) or during follow-up (nϭ22

show abstract

Dolichoectatic basilar artery: a review of 23 cases.

Cited by 117 publications

References 20 publications

Remarkable variability in renal disease in a large Slovenian family with Fabry disease

Remarkable variability in renal disease in a large Slovenian family with Fabry disease

Fusiform aneurysm of the vertebrobasilar arterial system.

Intracranial Bleeding in Patients With Vertebrobasilar Dolichoectasia

Contact Info

Product

Resources

About