Dolantin, ein neuartiges Spasmolytikum und Analgetikum

Stereochemical Factors and Receptor Interactions Associated with Narcotic Analgesics

“…This idea prevailed (74) until 1939, when Bisleb and Schaurnann (75) discovered that rrieperidine (XI) possessed substantial analgesic activity. The structural relationship between morphine and meperidine was realiLed and it was postulated (76) that the 4-phenylpiperidine moiety was necessary for anal- N-methyl group in mel'eridine by the cinnamyl substituent enhances activity by thirty to fortyfold while an identical change in morphine causes a loss of potency (see Table ITII).…”

Pethidine as an. Obstetric Analgesic

“…Because of its depressant effect on smooth muscle tissue its spasmolytic properties have been compared to those of atropine and papaverine. Several authors have claimed that it can antagonize the effects of acetylcholine and histamine on the intestine (Eisleb and Schaumann, 1939;Duguid and Heathcote, 1940;Schaumann, 1940). Gruber et al (1941) could not acknowledge the spasmolytic action.…”

“…The actual duration of labour, however, from the time of administration of the pethidine in both primigravidae and multigravidae falls well within, if not below, average time limits. Gilbert and Dixon (1943) report that in their series pethidine noticeably shortened the-duration of labour in primiparae, and Roby and Schumann (1943) state that the drug does not prolong labour.…”

Arrhythmogenic, Antiarrhythmic and Inotropic Properties of Opioids

“…Side effects of morphine led to use of pethidine [Eisleb and Schaumann, 1939]. Pethidine was derived from a series of atro pine-like spasmolytic compounds, but hav ing morphine-like analgesic activity.…”