Pethidine as an. Obstetric Analgesic

Gallen, Redelia; Prescott, Frederick; Spitzer, Walter O.

doi:10.1097/00000542-194409000-00031

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…When choosing an analgesic technique for labour pain, side effects must also be considered. Our study, as well as others, emphasises the relatively frequent problems of nausea, vomiting and sedation associated with pethidine 21,22 . Another even more important factor is the effect on the newborn, where depressive effects have been noted for up to several days postpartum 8,9 .…”

Section: Discussionsupporting

confidence: 61%

Lack of analgesic effect of systemically administered morphine or pethidine on labour pain

Olofsson

Ekblom

Ekman-Ordeberg

et al. 1996

BJOG

176

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Objective To evaluate the true analgesic effect of morphine and pethidine on labour pain. Design The analgesic and sedative effects of intravenous morphine or pethidine and their effect on anxiety were compared in a prospective, double‐blind, randomised dose‐response study. Setting A Stockholm teaching hospital obstetric unit. Participants Ten healthy nulliparous parturients in active labour were included in each group. Results Even after repeated doses (up to 0.15 mgkg body weight morphine and up to 15 mag body weight pethidine) the findings were uniform, with very high pain scores maintained in each group as assessed with visual analogue scale. The parturients were all significantly sedated and several fell asleep but were awakened by pain during contractions. Conclusion It is concluded that labour pain is not sensitive to systemically administered morphine or pethidine. These drugs only cause heavy sedation. It therefore seems unethical and medically incorrect to meet parturients' requests for pain relief by giving them sedation. Considering the well documented negative effects on newborn infants we also believe systemic pethidine should be avoided in labour.

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Section: Discussionsupporting

confidence: 61%

Lack of analgesic effect of systemically administered morphine or pethidine on labour pain

Olofsson

Ekblom

Ekman-Ordeberg

et al. 1996

BJOG

176

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show abstract

“…Rees et al (1967) have concluded that 'because of its circulatory effects, pethidine does not seem to be the ideal drug for the relief of pain of myocardial infarction'. An initial increase in mean aortic BP after pethidine has also been reported in healthy individuals by Prescott et al (1949) and in obstetric patients by Gallen & Prescott (1944).…”

Section: Pethidinesupporting

confidence: 55%

Pharmacological and clinical importance of narcotic antagonists and mixed antagonists‐use in cardiology.

Coltart¹,

Malcolm²

1979

Brit J Clinical Pharma

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1 The treatment of pain of cardiac origin requires a knowledge of the haemodynamic action of the analgesic agents used. 2 The haemodynamic effects of morphine, diamorphine, pavaveretum, pethidine and pentazocine are reviewed. 3 Clinical experience with the new antagonist analgesic buprenorphine is reported. 4 These studies indicate that buprenorphine may be the agent of choice for the relief of severe pain in patients with unstable circulation.

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Pethidine as an. Obstetric Analgesic

Cited by 2 publications

References 4 publications

Lack of analgesic effect of systemically administered morphine or pethidine on labour pain

Lack of analgesic effect of systemically administered morphine or pethidine on labour pain

Pharmacological and clinical importance of narcotic antagonists and mixed antagonists‐use in cardiology.

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