Dogs with Leishmania chagasi infection have semen abnormalities that partially revert during 150 days of Allopurinol and Amphotericin B therapy

Assis, Viviane Pedersoli; Ribeiro, Vítor Márcio; Rachid, Milene Alvarenga; Castro, Antônio Carlos Leal de; Valle, Guilherme Ribeiro

doi:10.1016/j.anireprosci.2009.03.003

Cited by 17 publications

(18 citation statements)

References 13 publications

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“…30,39,40 These results indicate that chronic infection by T. cruzi had no effect on the reproductive parameters of male dogs. This result differs from the findings reported by other authors who carried out experiments in Leishmania chagasi-infected dogs, 20 T. congolense-infected New Zealand White rabbits, 21 and T. brucei-infected West African dwarf bucks, 18 or red fronted gazelles 22 during the acute stage of infection.…”

Section: Discussioncontrasting

confidence: 57%

“…[7][8][9][10]12,15,16,[18][19][20][21][22][23][24] However, information is scarce and controversial regarding T. cruzi infections (that affect the reproductive system) and the direct transmission of such infections through coitus. 11,13,14 The latest report by Carvalho and others 17 showed that T. cruzi can colonize different cells, including myod cells, and suggested the possibility of parasite migration to the seminal fluid in case of a rupture of these cells.…”

Section: Discussionmentioning

confidence: 99%

“…These researchers have also reported the shedding of parasites in the semen accompanied by several reproductive disorders, such as low semen quality, reduced libido, testicular degeneration, impaired spermatogenesis, and alterations in the extracellular matrix of the lamina propria of the seminiferous tubules. [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] The presence of trypanosomatids in the semen of infected dogs indicates the possibility of venereal transmission of CD. Therefore, the use of chagasic dogs as sires should be avoided.…”

Section: Introductionmentioning

confidence: 99%

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Sperm Morphological Features Associated with Chronic Chagas Disease in the Semen of Experimentally Infected Dogs

Rodríguez-Morales

Pedro-Martínez

Hernández-Pichardo

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Abstract. The presence of trypanosomatids in the reproductive systems of different mammals (causing genital lesions in the acute stage of the disease) may predispose the animals to low semen quality. However, there are no studies examining the alterations in the sperm morphological features in the chronic stage of Trypanosoma cruzi infection. Knowledge of these aspects is important to understand the other ways of transmission of the Chagas disease. Progressive motility, mass motility, concentration, and sperm morphology of 84 ejaculates of dogs that were chronically infected with T. cruzi were evaluated. Most of the findings were consistent with the reference values and with those obtained from healthy control dogs. The scrotal circumference was not correlated with spermatozoa concentration in the infected animals. In conclusion, the T. cruzi Ninoa (MHOM/MX/1994/Ninoa) strain does not cause significant alterations in the semen quality of dogs experiencing chronic Chagas disease (at concentrations of 5

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Section: Discussioncontrasting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sperm Morphological Features Associated with Chronic Chagas Disease in the Semen of Experimentally Infected Dogs

Rodríguez-Morales

Pedro-Martínez

Hernández-Pichardo

et al. 2014

The American Society of Tropical Medicine and Hygiene

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“…Contributing to their hypothesis, Assis et al (2010) found semen with sperm defects suggestive of epididymal disfunction on L. infantum infected dogs. Therefore, a high percentage of positivity was expected in the semen (collected in our experiment) with sperm rich fraction.…”

Section: Discussionmentioning

confidence: 99%

“…Only ejaculates containing epididymal sperm rich fraction were used, characterized by live motile spermatozoa present in a drop microscopically analyzed between a slide and a coverslip (Assis et al, 2010). Samples of 0.5mL from these ejaculates were also transferred to sterile tubes and stored at -20ºC until analysis.…”

Section: Materials E Methodsmentioning

confidence: 99%

Detection of Leishmania infantum in the smegma of infected dogs

Silva

Assis

Ribeiro

et al. 2014

Arq. Bras. Med. Vet. Zootec.

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Considering the venereal transmission of visceral leishmaniasis from dogs to bitches, the aim of this study was to verify if the penile surface and smegma from infected dogs can be the source of parasites in bitches. Twelve Leishmania infantum infected dogs had semen and smegma samples collected for submission to PCR identification of the DNA of the parasite. Semen (41.7%) and smegma (50.0%) have similar positive incidence (P>0.05; Fisher's exact test), with 58.3% of the dogs positive for semen and/or smegma samples. The proportion of positivity for both semen and smegma was 33.3%, but 8.3% was positive only for semen, and 16.7% only for smegma, revealing a moderate agreement between tests (K=0.5; Kappa index). It was concluded that Leishmania infantum is present in the smegma of contaminated dogs and it can be a source of parasites for the semen and the bitch.Keywords: Leishmania infantum; dog; prepuce, smegma; semen Palavras-chave: Leishmania infantum, cão, prepúcio, esmegma, sêmen RESUMO Tendo em vista a transmissão venérea da leishmaniose visceral do cão para a cadela, o objetivo deste estudo foi verificar se a superfície peniana e o esmegma de cães infectados poderiam ser a fonte de parasitas para a fêmea. Amostras de sêmen e esmegma de 12 cães infectados com

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