Dogs, distemper and Paget's disease

Mee, Andrew P.; Sharpe, Paul T.

doi:10.1002/bies.950151203

Cited by 34 publications

(6 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has an unknown etiology, but a viral infection such as the canine distemper virus is likely. 33 Paget's disease comes in three phases, although not all phases may present in the patient. The first phase is characterized by osteoclastic resorption with osteopenia on the radiographs.…”

Section: Paget's Diseasementioning

confidence: 99%

Bone Marrow Edema Pattern around the Knee on Magnetic Resonance Imaging Excluding Acute Traumatic Lesions

Steinbach

Suh²

2011

Semin Musculoskelet Radiol

View full text Add to dashboard Cite

Magnetic resonance imaging (MRI) is very sensitive for the detection of marrow abnormalities. Bone marrow edema on MRI has been defined as an area of low signal intensity on T1-weighted images, associated with intermediate or high signal intensity findings on T2-weighted images. The bone marrow edema pattern is a nonspecific finding with multiple etiologies. The knee is a common place for bone marrow signal abnormalities to appear on MRI. Besides contusions and fractures from acute trauma, there are a variety of other causes of the bone marrow edema pattern. It is important for the interpreter of the study to be aware of the different etiologies responsible for producing these changes and to be able to narrow the differential diagnosis without mistaking such a pattern for acute trauma or infiltrative tumor. This article concentrates on those entities that produce a bone marrow edema pattern not related to acute trauma including red marrow proliferation, stress, osteochondral lesions, osteonecrosis, bone marrow edema syndrome, arthropathy, infection, Paget's disease, and marrow replacement disorders.

show abstract

Section: Paget's Diseasementioning

confidence: 99%

Bone Marrow Edema Pattern around the Knee on Magnetic Resonance Imaging Excluding Acute Traumatic Lesions

Steinbach

Suh²

2011

Semin Musculoskelet Radiol

View full text Add to dashboard Cite

show abstract

“…ferrets, badgers, and mink) families [ 2 – 4 ]. Previous studies had implicated CDV in the pathogenesis of Paget’s disease [ 5 ], and natural CDV infection of non-human primates has been reported [ 6 – 8 ]. In 2006, a CDV outbreak occurred in rhesus monkeys (Macaca mulatta) at a breeding farm in Guangxi province, China, with a morbidity rate (60 %) and a mortality rate (≈30 %), unexpectedly [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Canine distemper virus isolated from a monkey efficiently replicates on Vero cells expressing non-human primate SLAM receptors but not human SLAM receptor

Feng

Liu²,

Wang

et al. 2016

BMC Vet Res

View full text Add to dashboard Cite

BackgroundIn 2008, an outbreak of canine distemper virus (CDV) infection in monkeys was reported in China. We isolated CDV strain (subsequently named Monkey-BJ01-DV) from lung tissue obtained from a rhesus monkey that died in this outbreak. We evaluated the ability of this virus on Vero cells expressing SLAM receptors from dog, monkey and human origin, and analyzed the H gene of Monkey-BJ01-DV with other strains.ResultsThe Monkey-BJ01-DV isolate replicated to the highest titer on Vero cells expressing dog-origin SLAM (105.2±0.2 TCID50/ml) and monkey-origin SLAM (105.4±0.1 TCID50/ml), but achieved markedly lower titers on human-origin SLAM cells (103.3±0.3 TCID50/ml). Phylogenetic analysis of the full-length H gene showed that Monkey-BJ01-DV was highly related to other CDV strains obtained during recent CDV epidemics among species of the Canidae family in China, and these Monkey strains CDV (Monkey-BJ01-DV, CYN07-dV, Monkey-KM-01) possessed a number of amino acid specific substitutions (E276V, Q392R, D435Y and I542F) compared to the H protein of CDV epidemic in other animals at the same period.ConclusionsOur results suggested that the monkey origin-CDV-H protein could possess specific substitutions to adapt to the new host. Monkey-BJ01-DV can efficiently use monkey- and dog-origin SLAM to infect and replicate in host cells, but further adaptation may be required for efficient replication in host cells expressing the human SLAM receptor.

show abstract

“…The virus particles resembled members of the paramyxovirus family, including respiratory syncytial, measles or canine distemper virus. Such a viral hypothesis was also in keeping with some epidemiological observations indicating an increased prevalence of PDB in rural areas and particularly in subjects reporting contacts with dogs and/or different animal species [2,30,40,41]. Following these initial reports, many attempts using different techniques have been made to detect evidence of paramyxoviruses in bone and blood samples from patients with this disease, but the results have been conflicting [42][43][44][45][46][47][48].…”

Section: Environment Viral Infections and Pdbmentioning

confidence: 63%