Canine distemper virus isolated from a monkey efficiently replicates on Vero cells expressing non-human primate SLAM receptors but not human SLAM receptor

Feng, Na; Liu, Yuxiu; Wang, Jianzhong; Xu, Weiwei; Li, Tiansong; Wang, Tiecheng; Wang, Lei; Yu, Yicong; Wang, Hualei; Zhao, Yongkun; Wang, Cuiling; Gao, Yuwei; Hu, Guang‐Wan; Xia, Xianzhu

doi:10.1186/s12917-016-0757-x

Cited by 21 publications

(20 citation statements)

References 20 publications

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“…Phylogenetic analysis of the full-length H gene showed that Monkey CYN07-dV [58] and Monkey-BJ01-DV were highly related to other CDV strains obtained from species of the Canidae family in China during this time period. The monkey CDV strains (Monkey-BJ01-DV, CYN07-dV, Monkey-KM-01) possess a number of amino acid-specific substitutions (E276V, Q392R and D435Y) compared to the H protein of CDV occurring in other animals for the same period [57,71]. An additional change from I542F in these monkey strains is also noted from our current analysis.…”

Section: Genetic Analysis Of Cross Species Infectionsupporting

confidence: 61%

“…The majority of CDV strains isolated from Canidae have tyrosine at site 549, whereas CDV strains from other carnivore families mostly have histidine [76]. The specificity with which CDV-H interacts with SLAM and its potential as a determinant of host range have been investigated [71,76,82,83,84,85,86]. Amino acid residues Y525, D526 and R529 of CDV-H have been identified by site-directed mutagenesis to interact with SLAM [85].…”

Section: Virus Adaption To Cell Entry Receptorsmentioning

confidence: 99%

“…Specific sites in the H protein of all morbilliviruses are conserved to facilitate efficient SLAM binding [71]. A study by Nikolin et al [76] showed changes in the SLAM receptor binding site on H with adaption to non-canine species and correlated with functional receptor binding assays.…”

Section: Virus Adaption To Cell Entry Receptorsmentioning

confidence: 99%

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Canine and Phocine Distemper Viruses: Global Spread and Genetic Basis of Jumping Species Barriers

Kennedy

Earle

Omar

et al. 2019

Viruses

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Canine distemper virus (CDV) and phocine distemper (PDV) are closely-related members of the Paramyxoviridae family, genus morbillivirus, in the order Mononegavirales. CDV has a broad host range among carnivores. PDV is thought to be derived from CDV through contact between terrestrial carnivores and seals. PDV has caused extensive mortality in Atlantic seals and other marine mammals, and more recently has spread to the North Pacific Ocean. CDV also infects marine carnivores, and there is evidence of morbillivirus infection of seals and other species in Antarctica. Recently, CDV has spread to felines and other wildlife species in the Serengeti and South Africa. Some CDV vaccines may also have caused wildlife disease. Changes in the virus haemagglutinin (H) protein, particularly the signaling lymphocyte activation molecule (SLAM) receptor binding site, correlate with adaptation to non-canine hosts. Differences in the phosphoprotein (P) gene sequences between disease and non-disease causing CDV strains may relate to pathogenicity in domestic dogs and wildlife. Of most concern are reports of CDV infection and disease in non-human primates raising the possibility of zoonosis. In this article we review the global occurrence of CDV and PDV, and present both historical and genetic information relating to these viruses crossing species barriers.

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Section: Genetic Analysis Of Cross Species Infectionsupporting

confidence: 61%

Section: Virus Adaption To Cell Entry Receptorsmentioning

confidence: 99%

See 1 more Smart Citation

Canine and Phocine Distemper Viruses: Global Spread and Genetic Basis of Jumping Species Barriers

Kennedy

Earle

Omar

et al. 2019

Viruses

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“…SLAM has known as one of receptor against morbilliviruses and is used as a gate for viral entry because it is expressed on the surface of lymphocytes [ 12 ]. In this study, new Vero cells expressing dSLAM gene were constructed to isolate field CDV circulating in Korean dog population as other researchers constructed cells expressing dSLAM gene [ 10 20 ]. We successfully isolated only one virus in Vero/dSLAM cells from 17 suspected samples.…”

Section: Discussionmentioning

confidence: 99%

Isolation and molecular characterizations of canine distemper virus from a naturally infected Korean dog using Vero cells expressing dog signaling lymphocyte activation molecule

et al. 2020

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Background: Canine distemper virus (CDV) infection results in high morbidity and mortality in dogs. There has been no report about Isolation of Korean CDV since 1980 in Korea. Objectives: To investigate the biological properties and the genetic characterization of Korean CDV. Methods: Vero cells expressing dog signaling lymphocyte activation molecule (dSLAM) gene named as Vero/dSLAM were used to isolate CDV using 17 samples. Diagnostic methods such as cytopathic effects, immunofluorescence assay, peroxidase linked assay, electron microscopy, rapid immunodiagnostic assay, and reverse transcription polymerase chain reaction were used to confirm the Korean CDV isolate as a CDV. The genetic analysis was performed through cloning and sequencing of hemagglutinin gene of CDV isolate. Results: A virus propagated in Vero/dSLAM cell was confirmed as CDV (CD1901 strain) based on the above methods. The CD1901 strain showed the highest viral titer (10 5.5 50% tissue culture infectious dose [TCID 50 ]/mL) in the Vero/dSLAM cells at 4 days post inoculation, but did not form a fork on chorioallantoic membrane of 7-day-old egg. Ribavirin, a nucleotide analogue anti-viral agent, inhibits moderately the Korean CDV propagation in the Vero/dSLAM cells. The nucleotide and amino acid sequences of the H gene of CD1901 strain were compared with those of other CDV strains. The CD1901 strain belonged to Asia 1 group and had the highest similarity (99.9%) with the BA134 strain, which was isolated in China in 2008. Conclusions: We constructed successfully Vero/dSLAM and isolated one Korean CDV isolate (CD1901 strain) from a naturally infected dog. The CD1901 strain belonged to Asia 1 genotype.

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“…In this regard, the essential cause can be the substitutions in the isolated H protein and the CDV H protein. Moreover, while the amino acid sequence identity of the dog SLAM and the monkey SLAM is only 63.6%; the Monkey-BJ01-DV strain is able to replicate itself on the Vero cells expressing the SLAM receptors and originating from dogs as efficiently as the Vero cells which originate from monkey SLAM [101], indicating a potential cross-species event.…”

Section: Main Textmentioning

confidence: 99%

Tropism and molecular pathogenesis of canine distemper virus

Rendón-Marín

Budaszewski

Canal

et al. 2019

Virol J

103

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Background Canine distemper virus (CDV), currently termed Canine morbillivirus , is an extremely contagious disease that affects dogs. It is identified as a multiple cell tropism pathogen, and its host range includes a vast array of species. As a member of Mononegavirales , CDV has a negative, single-stranded RNA genome, which encodes eight proteins. Main body Regarding the molecular pathogenesis, the hemagglutinin protein (H) plays a crucial role both in the antigenic recognition and the viral interaction with SLAM and nectin-4, the host cells’ receptors. These cellular receptors have been studied widely as CDV receptors in vitro in different cellular models. The SLAM receptor is located in lymphoid cells; therefore, the infection of these cells by CDV leads to immunosuppression, the severity of which can lead to variability in the clinical disease with the potential of secondary bacterial infection, up to and including the development of neurological signs in its later stage. Conclusion Improving the understanding of the CDV molecules implicated in the determination of infection, especially the H protein, can help to enhance the biochemical comprehension of the difference between a wide range of CDV variants, their tropism, and different steps in viral infection. The regions of interaction between the viral proteins and the identified host cell receptors have been elucidated to facilitate this understanding. Hence, this review describes the significant molecular and cellular characteristics of CDV that contribute to viral pathogenesis. Electronic supplementary material The online version of this article (10.1186/s12985-019-1136-6) contains supplementary material, which is available to authorized users.

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Canine distemper virus isolated from a monkey efficiently replicates on Vero cells expressing non-human primate SLAM receptors but not human SLAM receptor

Cited by 21 publications

References 20 publications

Canine and Phocine Distemper Viruses: Global Spread and Genetic Basis of Jumping Species Barriers

Canine and Phocine Distemper Viruses: Global Spread and Genetic Basis of Jumping Species Barriers

Isolation and molecular characterizations of canine distemper virus from a naturally infected Korean dog using Vero cells expressing dog signaling lymphocyte activation molecule

Tropism and molecular pathogenesis of canine distemper virus

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