Does Vitamin D Modulate Asymmetric Dimethylarginine and C-Reactive Protein Concentrations?

Ngo, D.; Sverdlov, Aaron L.; McNeil, John J; Horowitz, John D.

doi:10.1016/j.amjmed.2009.09.024

Cited by 106 publications

(103 citation statements)

References 40 publications

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“…Ngo et al (Ngo et al 2010), in a cohort of 253 middle-aged and older subjects (mean, 63.4±6 years), have found that low 25(OH)D levels were inversely associated with hsCRP levels. Consistently, an inverse relationship between serum 25(OH)D status and TNF-α concentrations was documented by Peterson et al (Peterson and Heffernan 2008) in a study population of 25(OH)D-deficient women (age range, 25-82 years).…”

Section: Discussionmentioning

confidence: 97%

“…Our findings are of importance because little it is known about the relationship between 25(OH)D levels and immune markers of inflammation, especially in the elderly. The few published data coming from observational studies (Amer and Qayyum 2012;Reyman et al 2013;Laird et al 2014;Ngo et al 2010;Peterson and Heffernan 2008) support a primary anti-inflammatory role of vitamin D. In a very recent observational investigation conducted in 957 older Irish adults (>60 years of age), Laird et al (Laird et al 2014) showed a significant association between low vitamin D status (25OH-D <25 nmol/L) and markers of inflammation including IL-6, TNF-α, IL-10, hsCRP, and the ratio of IL-6 to IL-10.…”

Section: Discussionmentioning

confidence: 99%

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Relationship between vitamin D and inflammatory markers in older individuals

Vita

Lauretani

Bauer

et al. 2014

AGE

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In older persons, vitamin D insufficiency and a subclinical chronic inflammatory status frequently coexist. Vitamin D has immune-modulatory and in vitro anti-inflammatory properties. However, there is inconclusive evidence about the anti-inflammatory role of vitamin D in older subjects. Thus, we investigated the hypothesis of an inverse relationship between 25-hydroxyvitamin D (25(OH)D) and inflammatory markers in a population-based study of older individuals. After excluding participants with high-sensitivity C-reactive protein (hsCRP)≥10 mg/dl and those who were on chronic anti-inflammatory treatment, we evaluated 867 older adults ≥65 years from the InCHIANTI Study. Participants had complete data on serum concentrations of 25(OH)D, hsCRP, tumor necrosis factor (TNF)-α, soluble TNF-α receptors 1 and 2, interleukin (IL)-1β, IL-1 receptor antagonist, IL-10, IL-18, IL-6, and soluble IL-6 receptors (sIL6r and sgp130). Two general linear models were fit (model 1-adjusted for age, sex, and parathyroid hormone (PTH); model 2-including covariates of model 1 plus dietary and smoking habits, physical activity, ADL disability, season, osteoporosis, depressive status, and comorbidities). The mean age was 75.1±17.1 years±SD. In model 1, AGE (2014) log(25OH-D) was significantly and inversely associated with log(IL-6) (β±SE=−0.11±0.03, p=<0.0001) and log (hsCRP) (β±SE=−0.04±0.02, p=0.04) and positively associated with log(sIL6r) (β±SE=0.11±0.04, p=0.003) but not with other inflammatory markers. In model 2, log (25OH-D) remained negatively associated with log (IL-6) (β±SE=−0.10±0.03, p=0.0001) and positively associated with log(sIL6r) (β±SE=0.11± 0.03, p = 0.004) but not with log(hsCRP) (β ±SE= −0.01±0.03, p=0.07). 25(OH)D is independently and inversely associated with IL-6 and positively with sIL6r, suggesting a potential anti-inflammatory role for vitamin D in older individuals.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Relationship between vitamin D and inflammatory markers in older individuals

Vita

Lauretani

Bauer

et al. 2014

AGE

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“…Vitamin D3 may have an independent and direct role in the regulation of BP and insulin metabolism [215][216][217][218][219][220][221][222][223][224][225] . Vitamin D influences BP by its effects on calcium-phosphate metabolism, RAA system, immune system, control of endocrine glands and ED [216] .…”

Section: Vitamin Dmentioning

confidence: 99%

The role of nutrition and nutraceutical supplements in the treatment of hypertension

Houston¹

2014

WJC

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Vascular biology, endothelial and vascular smooth muscle and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension, cardiovascular disease and target organ damage. Nutrientgene interactions and epigenetics are predominant factors in promoting beneficial or detrimental effects in cardiovascular health and hypertension. Macronutrients and micronutrients can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.© 2014 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Hypertension; Nutrition; Nutritional supplements; Cardiovascular disease; Vascular biology Core tip: Vascular biology and endothelial dysfunction play a primary roles in hypertension and subsequent cardiovascular disease. Micronutrients, macronutrients and optimal nutrition and nutritional supplements can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. These treatments are complementary to drug therapy. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.Houston M. The role of nutrition and nutraceutical supplements in the treatment of hypertension. World J Cardiol 2014; 6(2): 38-66 Available from:

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“…Moreover, Molinari et al (65) illustrated that 1,25(OH)2D, produces a dose-dependent increase in NO production in cultured endothelial cells, with the involvement of VDRs, by activation of eNOS. Additionally, Ngo et al (66) highlighted an inverse correlation between 25(OH)D and ADMA levels in an ambulatory, healthy population. Worth mentioning is that our laboratory investigated the same association, as well as the association between 25(OH)D and ADMA's regioisomer symmetric dimethylarginine (SDMA), however in coronary artery disease patients, and found no significant correlation between the parameters (Fig.…”

Section: Increases Insulin Resistancementioning

confidence: 99%

“…Recently, Finch et al (68) elucidated an increase in the expression of p22(phox) protein, a subunit of NADPH oxidase, in uremic rats compared to controls, which was counteracted by the addition of the VDR activator, pari- (66,70). Molecular studies aiming to clarify the underlying mechanisms linking vitamin D with inflammation include those proposing vitamin D exerts its anti-inflammatory property by decreasing the activity of NF-kB (63).…”

Section: Increases Insulin Resistancementioning

confidence: 99%

Vitamin D Deficiency and Cardiovascular Disease: Potential Mechanisms and Novel Perspectives

Maaty

2013

J Nutr Sci Vitaminol

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Summary Interest in contemporary vitamin D research has been sparked in recent years, stemming from the identification of vitamin D receptors in virtually all cells as well as the enzymatic machinery necessary to produce its active form. Both epidemiological and invitro studies have linked vitamin D deficiency to enigmatic diseases including cardiovascular disease; however, a clear mechanistic link remains missing. This review highlights conclusions of observational studies, in-vitro experiments and randomized-controlled trials that aimed to link deficiency of the sunshine vitamin to one of the leading causes of death in the world, cardiovascular disease. Furthermore, putative mechanisms viewed from a novel perspective are also discussed.

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Does Vitamin D Modulate Asymmetric Dimethylarginine and C-Reactive Protein Concentrations?

Cited by 106 publications

References 40 publications

Relationship between vitamin D and inflammatory markers in older individuals

Relationship between vitamin D and inflammatory markers in older individuals

The role of nutrition and nutraceutical supplements in the treatment of hypertension

Vitamin D Deficiency and Cardiovascular Disease: Potential Mechanisms and Novel Perspectives

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