Does Vitamin D Improve Muscle Strength in Adults? A Randomized, Double-blind, Placebo-controlled Trial Among Ethnic Minorities in Norway

Knutsen, Kirsten V.; Madar, Ahmed A.; Lagerløv, Per; Brekke, Mette; Raastad, Truls; Stene, Lars C.; Meyer, Haakon E

doi:10.1210/jc.2013-2647

Cited by 43 publications

(58 citation statements)

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“…In the current study, very few of our participants had 25(OH)D concentrations greater than 50 nmol/L and yet an association between 25(OH)D and muscle strength was observed. In a previous RCT among immigrants in Oslo, it was also reported that even after supplementation, 62% (in 400 IU vitamin D group) and 43% (1000 IU vitamin D group) of the participants in the study did not reach serum 25(OH)D levels ≥ 50 nmol/L [1]. It is worth pointing out that the target of 50 nmol/L is primarily based on studies performed in Caucasians and some studies suggest that the association between 25(OH)D and health outcomes are different in other ethnic groups [36].…”

Section: Factors Affecting Vitamin D Statusmentioning

confidence: 84%

“…Further investigation of their earlier study found that the improvement in hand grip strength was only in males, suggesting a possible gender-specific difference [34]. With lower doses of vitamin D supplementation (400 IU/day and 1000 IU/day), no significant improvement in muscle strength was seen among immigrants with ethnic backgrounds of Middle Eastern, African and South Asian in Oslo (aged 18-50 years) [1]. It is worth noting that hand grip strength was used to assess muscle strength in all of these three RCTs, which has been found to be less sensitive in assessing changes in muscle strength and physical performance [7,35].…”

Section: Factors Affecting Vitamin D Statusmentioning

confidence: 90%

“…There are limited randomised controlled trials (RCT) investigating the effect of vitamin D on muscle strength in people from sunnier climate countries visiting West countries [1]. Furthermore, no longitudinal data studying the relationship between vitamin D and muscle strength and how this relationship is affected by emigrating from low to high latitudes exists.…”

Section: Introductionmentioning

confidence: 99%

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The relationship between vitamin D status and muscle strength in young healthy adults from sunny climate countries currently living in the northeast of Scotland

et al. 2017

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The relationship between vitamin D status and muscle strength in young healthy adults from sunny climate countries currently living in the northeast of Scotland. Osteoporosis International, 28(4), pp. 1433-1443. (doi:10.1007 This is the author's final accepted version.There may be differences between this version and the published version. 1 Abstract SummaryThe current study examined the relationship between vitamin D status and muscle strength in young healthy adults: residents (> 6 months) and newcomers (0-3 months), originally from sunny climate countries but currently living in the northeast of Scotland. Our longitudinal data found a positive, albeit small, relationship between vitamin D status and knee extensor isometric strength. IntroductionVitamin D has been suggested to play a role in muscle health and function, but studies so far have been primarily in older populations for falls prevention and subsequent risk of fractures.

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Section: Factors Affecting Vitamin D Statusmentioning

confidence: 84%

Section: Factors Affecting Vitamin D Statusmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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The relationship between vitamin D status and muscle strength in young healthy adults from sunny climate countries currently living in the northeast of Scotland

et al. 2017

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“…30 In critically ill patients, interventional studies have shown vitamin D supplementation to be safe at a low IV dose 500 IU per day 55 and a single high enteral dose of 540,000 IU per day without causing significant hypercalcemia or hypercalciuria. 56 In an observational trial of 258 critically ill trauma, vascular, and surgical patients, where it was standard practice to supplement with 50,000 IU of enteral vitamin D per week, there were no reported adverse reactions or hypercalcemia.…”

Section: Safetymentioning

confidence: 99%

Outcomes of Vitamin D Supplementation in Adults Who are Deficient and Critically Ill: A Review of the Literature

Williams

Heuberger

2016

American Journal of Therapeutics

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Vitamin D deficiency is known to be common in the general population and has been linked to all-cause mortality. The classically recognized role of vitamin D is its involvement in calcium and phosphorous homeostasis and bone health. Recent evidence suggests that vitamin D may also play a role in other nonskeletal processes, such as anti-proliferation, immunity, regulation of hormone section, and muscle strength. An extensive literature review of vitamin D and critical illness from 2000 to 2015 (PubMed and CINAL) produced multiple observational studies revealing a high prevalence of vitamin D deficiency in intensive care patients. Many of these studies have indicated that there is an association between vitamin D deficiency and clinical outcomes such as mortality, sepsis, duration of mechanical ventilation, and length of stay. This review article provides an overview of vitamin D physiology in adults, a summary of observational studies on vitamin D deficiency in critical illness, and an examination of the few clinical trials on vitamin D supplementation in intensive care patients.

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“…Knowledge about vitamin D and muscle function in a younger adult population is limited. Vitamin D supplementation increased muscle power in young Arabic women (16) and improved physical performance in a small trial in 40 healthy volunteers with hypovitaminosis D (17), but not all studies showed an effect (18).…”

Section: Introductionmentioning

confidence: 97%

Effect of vitamin D supplementation on physical performance and activity in non-western immigrants

Oosterwerff¹,

Meijnen²,

Schoor³

et al. 2014

Endocrine Connections

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Vitamin D deficiency is highly prevalent among non-western immigrants in The Netherlands and associated with poor physical performance. The aim of this study was to assess the effect of vitamin D supplementation on physical performance, exercise capacity, and daily physical activity in vitamin D-deficient, overweight non-western immigrants. A randomized double-blind, placebo-controlled trial was conducted to assess the effect of vitamin D on physical performance. A total of 130 participants were included. Eligibility criteria included overweight (BMI >27 kg/m2), 25-hydroxy vitamin D (25(OH)D) ≤50 nmol/l, and an age range of 20–65 years. The intervention group received 1200 IU vitamin D3 daily for 4 months; the control group received placebo. Both groups received 500 mg calcium daily. Outcome measures included physical performance (physical performance score), exercise capacity (a 6-min walk test (6-MWT)), and daily physical activity (questionnaire and accelerometer). There was no significant effect on physical performance, exercise capacity, or physical activity in the intention to treat analysis. In an explorative post hoc analysis restricted to participants reaching a serum 25(OH)D concentration of >60 nmol/l after intervention, there was an improvement of 19 m in the 6-MWT compared with the control group (P=0.053). Moderate dose vitamin D supplementation did not significantly improve physical performance, exercise capacity, or physical activity. However, when 25(OH)D concentrations reached >60 nmol/l after intervention, there was a borderline significant improvement in exercise capacity. Although the clinical relevance is not clear, this is a promising result, as all participants were overweight and did not improve their overall activity levels.

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Does Vitamin D Improve Muscle Strength in Adults? A Randomized, Double-blind, Placebo-controlled Trial Among Ethnic Minorities in Norway

Abstract: Daily supplementation with 25 or 10 μg vitamin D3 for 16 weeks did not improve muscle strength or power measured by the jump test, handgrip test, or chair-rising test in this population with low baseline vitamin D status.

Cited by 43 publications

References 44 publications

The relationship between vitamin D status and muscle strength in young healthy adults from sunny climate countries currently living in the northeast of Scotland

The relationship between vitamin D status and muscle strength in young healthy adults from sunny climate countries currently living in the northeast of Scotland

Outcomes of Vitamin D Supplementation in Adults Who are Deficient and Critically Ill: A Review of the Literature

Effect of vitamin D supplementation on physical performance and activity in non-western immigrants

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