Does video-assisted mediastinoscopy have a better lymph node yield and safety profile than conventional mediastinoscopy?

Abstract

A best evidence topic was written according to a structured protocol. The question addressed was whether video-assisted mediastinoscopy (VAM) has a better lymph node yield and safety profile than the conventional mediastinoscopy (CM). A total of 194 papers were found, using the reported searches, of which five represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. Two studies to date have directly compared CM and VAM with respect to lymph node yield, calculated diagnostics performance and complication rate. In both of these, lymph node yield is shown to be higher using VAM with better sensitivity, negative predictive value and accuracy rates. The favourable figures of lymph node sampling are found to be statistically significant in the single study providing such analysis. Complication rates using VAM are low, however, in the one instance where it is reported as higher than CM, the extensive lymph node dissection used in this technique may be a reasonable explanation for this finding. All studies described here exemplify VAM as a safe and useful tool in mediastinal staging, lymph node dissection and tissue diagnosis of mediastinal diseases given its superior visualization of surrounding structures and advantage of bimanual dissection. The future scope for diagnostic and therapeutic indications of cervical mediastinscopy is anticipated with recent advances and new techniques, such as video-assisted mediastinoscopic lymphadenectomy and virtual mediastinscopy.

GOECP/SEOR radiotheraphy guidelines for non-small-cell lung cancer

“…A positive PET scan should be further evaluated, regardless of lesion size[ 16 , 17 ], through EBUS or digestive endoscopic ultrasonography[ 18 - 20 ] (I, A). In uncertain cases, conventional mediastinoscopy or video-assisted mediastinoscopy and video-assisted thoracoscopy are surgical alternatives to obtain samples for subsequent analysis[ 21 , 22 ]. Peripheral lesions can be evaluated by CT-guided transthoracic fine-needle aspiration biopsy[ 14 , 23 ].…”

The role of surgery in the diagnosis and the treatment of pulmonary tuberculosis

“…Standard cervical mediastinoscopy, video-assisted mediastinoscopy (VAM) and video-assisted thoracoscopic surgery (VATS) are the minimally-invasive surgical methods for sampling of mediastinal lymph nodes. VAM allows better visualization and has a bet-ter diagnostic yield than standard mediastinoscopy, but with the almost equal sensitivity (95 vs. 92.2%) [18]. VATS is generally limited to the evaluation of one side of the mediastinum.…”

mRNA and miRNA analyses in cytologically positive endobronchial ultrasound‐guided transbronchial needle aspiration: Implications for molecular staging in lung cancer patients

“…Until recently, the gold standard for mediastinal metastasis staging has been mediastinoscopy . Overall mortality is approximately 0.05%; however, complications can affect health outcomes gravely in up to 3% of cases . The invasive nature of mediastinoscopy calls for an equivalent, but less invasive, procedure.…”

“…3 Overall mortality is approximately 0.05%; however, complications can affect health outcomes gravely in up to 3% of cases. 4,5 The invasive nature of mediastinoscopy calls for an equivalent, but less invasive, procedure. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive procedure for mediastinal lymph node sampling, which achieves a high sensitivity, between 79% and 99%, [6][7][8][9] and compensates for 2 main disadvantages of mediastinoscopy.…”