Does tramadol wound infiltration offer an advantage over bupivacaine for postoperative analgesia in children following herniotomy?

Demiraran, Yavuz; İlçe, Zekeriya; Kocaman, Buket; Bozkurt, Pervin

doi:10.1111/j.1460-9592.2006.01910.x

Cited by 47 publications

(33 citation statements)

References 23 publications

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“…In a study conducted on 75 pediatric herniotomy patients by Demiraran et al [16], 2 mg/kg tramadol used for wound infiltration provides approximately 2 h more analgesia compared to intramuscular tramadol. Similarly, it has been shown that 2 mg/kg tramadol used in peritonsillar infiltration prolongs the postoperative analgesia duration and reduces the need for additional analgesics and the incidence of side effects [4][5][6].…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of Submucosal Tramadol in the Postoperative Treatment of Pain Following Septoplasty Operations

Ekmekçi

Beriat

Bengisun

et al. 2012

Indian J Otolaryngol Head Neck Surg

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Tramadol is a centrally acting opioid which is effective for moderate-severe pain and is being used for various acute and chronic pain scenarios. The primary endpoint of this controlled, randomized double blind study was to evaluate the effect of submucosal tramadol on VAS scores after septoplasty operations and secondary endpoint was to investigate the effects on total opioid and additional analgesic consumption and patient satisfaction. 60 patients scheduled for septoplasty under general anaesthesia were enrolled. In Group T, at the end of surgery following hemostasis, 2 mg/kg tramadol was applied as submucosal infiltration to both surgical sites, 2 ml (total 4 ml), by the surgeon. In Group P, at the end of surgery following hemostasis, 2 ml isotonic solution (total 4 ml) was applied as submucosal infiltration to both surgical sites by the surgeon. Total opioid consumption, VAS scores, patient satisfaction was evaluated at the end of 24 h VAS values were higher in Group P on the first and second postoperative hours. Patient controlled analgesia demand and delivery values were higher in Group P on the postoperative 1, 2, 4, 6, 12 and 24th hours. Patient satisfaction was higher and opioid consumption was lower in Group T compared to Group P. There was no difference in additional analgesic consumption between two groups. The results show that patients receiving tramadol had lower VAS scores compared with the placebo groups postoperatively.

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Section: Discussionmentioning

confidence: 99%

The Efficacy of Submucosal Tramadol in the Postoperative Treatment of Pain Following Septoplasty Operations

Ekmekçi

Beriat

Bengisun

et al. 2012

Indian J Otolaryngol Head Neck Surg

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“…Tramadol may be used for peripheral nerve block and in wound infiltration due to its anesthetic effects [14][15][16][17][18][19][20] . No study has been found evaluating the effects of tramadol on wound healing, which it is the aim of this study.…”

Section: Discussionmentioning

confidence: 99%

“…Tramadol is a synthetic analogue of codeine, which acts through both opioid and non-opioid mechanisms of action 1,13 . Tramadol has shown similar effects to local anesthetics on peripheral nerves [14][15][16][17][18][19][20] . Tramadol may be used as a local anesthetic agent for minor surgeries; similarly, it may be used as an adjuvant to local anesthetics 21 .…”

Section: Introductionmentioning

confidence: 97%

“…Previous research using experimental models and fibroblast tissue cultures from surgical wounds had looked at the effect of local anesthetic agents such as bupivacaine, prilocaine and lidocaine on wound healing 3,28-31 . There are no known studies on the effects of tramadol, which may be used for wound infiltration and healing [14][15][16][17][18][19][20][21] .…”

Section: Introductionmentioning

confidence: 99%

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Comparação dos efeitos da infiltração com bupivacaína, lidocaína e tramadol na cicatrização de feridas em ratos

Hancı¹,

Hakimoğlu

Özaçmak

et al. 2012

Rev. Bras. Anestesiol.

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“…As ações opioides periféricas não são muito notórias no tecido normal, mas aparecem precocemente após a indução da inflamação Doz, 1993 (Demiraran et al, 2006). O tramadol prolongou a duração do efeito analgésico pós-operatório com segurança quando utilizado como droga adjunta à anestesia local do nervo peniano para realização de circuncisão em crianças de 5 a 13 anos sob sedação (Shrestha;Bista, 2005 • Grupo A: tramadol 50 mg intramuscular uma hora antes da cirurgia e 1 ml de soro fisiológico (SF) estéril submucoso no sítio cirúrgico após a anestesia.…”

Section: Administração Local Do Tramadolunclassified

Eficácia analgésica pós-operatória e ação anestésica adjuvante do cloridrato de tramadol utilizado localmente após exodontias de terceiros molares inferiores impactados

Ceccheti¹

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AGRADECIMENTOSÀ Profa. Dra. Maria da Graça Naclério-Homem, por acreditar sempre em meu potencial, pelo incentivo e apoio nessa jornada de 15 anos pós-graduação. Sua presença em minha vida trouxe oportunidades e desafios superados com grande alegria.À Profa. Maria Paula Siqueira de Melo Peres, por promover o ensino, a pesquisa e assistência na minha segunda casa, o Hospital das Clínicas. Obrigado pelo incentivo constante ao meu desenvolvimento. Foi estudado o efeito analgésico e anestésico adjuvante do cloridrato de tramadol aplicado localmente, após extração do terceiro molar inferior impactado. Um total de 52 pacientes foi submetido à exodontia sob anestesia local (mepivacaína 2% 1:20 000 corbadrina), em estudo duplo-cego, dose única, cruzado, controlado por placebo. Pacientes e os lados dos procedimentos foram distribuídos aleatoriamente para receberem 2 ml de tramadol (100%) (grupo T) ou 2 ml de solução salina 0,9% (grupo P). Ambas as soluções foram injetadas na submucosa gengival e alvéolo, imediatamente após as cirurgias realizadas por um mesmo cirurgião. Impacção dental e quantidade anestésica foram pareadas. Dados do consumo e a hora de uso The present study sought to assess the analgesic and adjuvant anesthetic effects of surgical site administration of tramadol hydrochloride immediately after extraction of impacted mandibular third molars. In this double-blind, placebo-controlled, singledose, crossover investigation, 52 patients underwent bilateral extraction of impacted mandibular third molars under local anesthesia (mepivacaine 2% with levonordefrin 1:20 000). Patients and procedures, by side of intervention, were randomly assigned to receive either 2 mL of tramadol (100%) (Group T, n = 52) or 2 mL of normal saline, 0.9% (Group P, n = 52). Medications were administered by submucosal injection at the level of the third molar immediately after surgery. All patients were operated on by the same surgeon; patients were paired for technical difficulty and amount of anesthetic solution. Use of supplementary analgesics (500 mg metamizole) and time to first postoperative use of a rescue drug were used to assess the analgesic effect of tramadol. Pain level on both sides (Group T and P) was recorded on a visual analog scale (VAS 0-10 cm) immediately after cessation of anesthetic effect and at 4, 8, 24, 48, and 72 hours postoperatively. Data were compared using the Wilcoxon test (p < 0.05). There was no difference in anesthetic blockade between groups. There were no differences in reported adverse effects. In the 72 hours following surgery, patients in group T took significantly fewer (p = 0.008) metamizole tablets (3.37 ± 4.65) than did those in group P (4.4 ± 3.71). Time to first dose of a rescue drug (in minutes) was longer in Group T (303.72 ± 416.01) than in Group P (185.4 ± 59.4) (p = 0.006).Tramadol reduced pain intensity values (VAS) significantly in Group T (3.55 ± 2.27) as compared to Group P (5.26 ± 2.49) after anesthetic effect had worn off (p = 0.001). Local administration of tramadol after oral surg...

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Does tramadol wound infiltration offer an advantage over bupivacaine for postoperative analgesia in children following herniotomy?

Abstract: Wound infiltration with tramadol may be a good choice for postoperative analgesia in children having inguinal herniotomy.

Cited by 47 publications

References 23 publications

The Efficacy of Submucosal Tramadol in the Postoperative Treatment of Pain Following Septoplasty Operations

The Efficacy of Submucosal Tramadol in the Postoperative Treatment of Pain Following Septoplasty Operations

Comparação dos efeitos da infiltração com bupivacaína, lidocaína e tramadol na cicatrização de feridas em ratos

Eficácia analgésica pós-operatória e ação anestésica adjuvante do cloridrato de tramadol utilizado localmente após exodontias de terceiros molares inferiores impactados

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