Does This Patient Have Parkinson Disease?

Rao, Goutham; Fisch, L; Srinivasan, Sukanya; D’Amico, Frank; Okada, Tadao; Eaton, Carolyn; Robbins, Craig

doi:10.1001/jama.289.3.347

Cited by 101 publications

(60 citation statements)

References 38 publications

(54 reference statements)

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“…The presence of these prosodic insufficiencies along with the cardinal motor symptoms may be essential for the differential diagnosis of PD (Rao et al, 2003).…”

Section: Speech Characteristics In Parkinson's Diseasementioning

confidence: 99%

Loudness perception and speech intensity control in Parkinson's disease

Clark

Adams

Dykstra

et al. 2014

Journal of Communication Disorders

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This study investigated the role of loudness perception and selected auditory processes in 17 participants with hypophonia related to Parkinson's disease (PD) and 25 controls. For most of the five loudness perception tasks (magnitude estimation, imitation, speech-to-noise judgment, magnitude production, magnitude production in noise), the PD participants produced a significantly different pattern and used a more restricted range than the controls in their self-generated estimates of speech intensity and judgments of speech loudness.Results from two self-assessment questionnaires (CETI-M, M-SAPP) found that the PD participants perceived themselves as less effective communicators than controls. An audiometric evaluation suggested that the PD participants may have abnormalities related to higher admittance values, higher acoustic reflex thresholds and higher pure-tone thresholds for lower frequencies. These results suggest that individuals with PD may have a speech loudness perception deficit involving the abnormal perception of externally-generated and self-generated speech intensity stimuli.

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“…The presence of these prosodic insufficiencies along with the cardinal motor symptoms may be essential for the differential diagnosis of PD (Rao et al, 2003).…”

Section: Speech Characteristics In Parkinson's Diseasementioning

confidence: 99%

Loudness perception and speech intensity control in Parkinson's disease

Clark

Adams

Dykstra

et al. 2014

Journal of Communication Disorders

View full text Add to dashboard Cite

show abstract

“…Currently, clinical diagnosis of PD is based on movement-related behavioral abnormalities (Rao et al 2003;Sethi 2002). However, the absence of distinct biomarkers for the prognosis of the disease, because of the lack of clear understanding of the disease process, has significantly hampered efforts to identify and treat PD patients early in the disease course.…”

mentioning

confidence: 99%

Parkinson's disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: role of neuroinflammation.

Liu

Gao

Hong

2003

Environ Health Perspect

255

191

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Idiopathic Parkinson's disease (PD) is a devastating movement disorder characterized by selective degeneration of the nigrostriatal dopaminergic pathway. Neurodegeneration usually starts in the fifth decade of life and progresses over 5-10 years before reaching the fully symptomatic disease state. Despite decades of intense research, the etiology of sporadic PD and the mechanism underlying the selective neuronal loss remain unknown. However, the late onset and slow-progressing nature of the disease has prompted the consideration of environmental exposure to agrochemicals, including pesticides, as a risk factor. Moreover, increasing evidence suggests that early-life occurrence of inflammation in the brain, as a consequence of either brain injury or exposure to infectious agents, may play a role in the pathogenesis of PD. Most important, there may be a self-propelling cycle of inflammatory process involving brain immune cells (microglia and astrocytes) that drives the slow yet progressive neurodegenerative process. Deciphering the molecular and cellular mechanisms governing those intricate interactions would significantly advance our understanding of the etiology and pathogenesis of PD and aid the development of therapeutic strategies for the treatment of the disease.

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“…Depression is one of the symptoms that manifests in females are specific symptoms that might help clinicians distinguish PD from other neurological disorders; patients would have a better chance of being diagnosed with PD if they show micrographia (handwriting problems), which is linked to bradykinesia, a shuffling walk, and difficulty with special motor tasks, such as opening jars, bed natural turnovers, and standing from a chair-sitting position [19]. There are opposite symptoms that indicate that patients would not have PD, such as falls at onset, lack of reaction to levodopa, symmetrical resting tremor or less tremors at the early stage of the disease, accelerated rate of progression, and autonomic nervous system dysfunctions (e.g., orthostasis, constipation, dysphagia, urinary difficulties, and sexual dysfunction) [20].…”

Section: Depression In Parkinson's Disease (Pd)mentioning

confidence: 99%