Structural Brain Sex Differences in Parkinson’s Disease: A Voxel-Based Morphometry Study

Alqarni, Abdullah

doi:10.4172/2329-6895.1000364

Cited by 2 publications

(2 citation statements)

References 71 publications

(125 reference statements)

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“…Of note, our brain age prediction model did not show a significant difference in Brain-PAD between male and female HC (training set: t (947) = 0.52, p = 0.60; hold-out set: t (103) = 0.56, p = 0.57). This result would suggest that the male sex is more influenced by disease-accelerated brain atrophy associated with aging in PD 7 , 21 .…”

Section: Discussionmentioning

confidence: 89%

“…Several previous studies have investigated sex differences in brain structure in PD using structural brain imaging, with some variability in the results 7 . In established PD, increased atrophy has been observed in males in extensive cortical and subcortical regions, as measured using VBM as well as cortical thickness 7 , 21 . According to a study conducted on the PPMI dataset, male de novo PwP exhibit greater cortical thinning in the pre- and post-central gyrus and lower volume of the basal ganglia, thalamus, and brainstem compared to their female counterparts 22 .…”

Section: Discussionmentioning

confidence: 99%

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Differences in brain aging between sexes in Parkinson’s disease

Beheshti,

Booth,

2024

npj Parkinsons Dis.

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Parkinson’s disease (PD) is linked to faster brain aging. Male sex is associated with higher prevalence, severe symptoms, and a faster progression rate in PD. There remains a significant gap in understanding the function of sex in the process of brain aging in PD. The structural T1-weighted MRI-driven brain-predicted age difference (i.e., Brain-PAD: the actual age subtracted from the brain-predicted age) was computed in a group of 373 people with PD (mean age ± SD: 61.37 ± 9.81, age range: 33–85, 34% female) from the Parkinson’s Progression Marker Initiative database using a robust brain-age estimation framework that was trained on 949 healthy subjects. Linear regression models were used to investigate the association between Brain-PAD and clinical variables in PD, stratified by sex. Males with Parkinson’s disease (PD-M) exhibited a significantly higher mean Brain-PAD than their female counterparts (PD-F) (t(256) = 2.50, p = 0.012). In the propensity score-matched PD-M group (PD-M*), Brain-PAD was found to be associated with a decline in general cognition, a worse degree of sleep behavior disorder, reduced visuospatial acuity, and caudate atrophy. Conversely, no significant links were observed between these factors and Brain-PAD in the PD-F group. Having ‘older’ looking brains in PD-M than PD-F supports the idea that sex plays a vital function in PD, such that the PD mechanism may be different in males and females. This study has the potential to broaden our understanding of dissimilarities in brain aging between sexes in the context of PD.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Differences in brain aging between sexes in Parkinson’s disease

Beheshti,

Booth,

2024

npj Parkinsons Dis.

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Sex effects on brain structure in de novo Parkinson’s disease: a multimodal neuroimaging study

Tremblay

Abbasi

Zeighami

et al. 2020

Brain

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Parkinson’s disease varies in severity and age of onset. One source of this variability is sex. Males are twice as likely as females to develop Parkinson’s disease, and tend to have more severe symptoms and greater speed of progression. However, to date, there is little information in large cohorts on sex differences in the patterns of neurodegeneration. Here we used MRI and clinical information from the Parkinson Progression Markers Initiative to measure structural brain differences between sexes in Parkinson’s disease after regressing out the expected effect of age and sex. We derived atrophy maps from deformation-based morphometry of T1-weighted MRI and connectivity from diffusion-weighted MRI in de novo Parkinson’s disease patients (149 males: 83 females) with comparable clinical severity, and healthy control participants (78 males: 39 females). Overall, even though the two patient groups were matched for disease duration and severity, males demonstrated generally greater brain atrophy and disrupted connectivity. Males with Parkinson’s disease had significantly greater tissue loss than females in 11 cortical regions including bilateral frontal and left insular lobe, right postcentral gyrus, left inferior temporal and cingulate gyrus and left thalamus, while females had greater atrophy in six cortical regions, including regions in the left frontal lobe, right parietal lobe, left insular gyrus and right occipital cortex. Local efficiency of white matter connectivity showed greater disruption in males in multiple regions such as basal ganglia, hippocampus, amygdala and thalamus. These findings support the idea that development of Parkinson’s disease may involve different pathological mechanisms and yield distinct prognosis in males and females, which may have implications for research into neuroprotection, and stratification for clinical trials.

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Structural Brain Sex Differences in Parkinson’s Disease: A Voxel-Based Morphometry Study

Cited by 2 publications

References 71 publications

Differences in brain aging between sexes in Parkinson’s disease

Differences in brain aging between sexes in Parkinson’s disease

Sex effects on brain structure in de novo Parkinson’s disease: a multimodal neuroimaging study

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