Does the spread of hepatitis B virus genotype A increase the risk of intrafamilial transmission in Japan?

Komatsu, Haruki; Sugawara, Hidenori; Inui, Ayano; Nagamine, Koichiro; Hiejima, Eitaro; Sogo, Tsuyoshi; Fujisawa, Tomoo

doi:10.1007/s10156-010-0107-z

Cited by 9 publications

(7 citation statements)

References 23 publications

(37 reference statements)

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“…Approximately 7.5% of adults infected with genotype A become HBV carriers in Japan . Therefore, there is a concern that adults infected with genotype A may become a new infectious pool of HBV . Fortunately, we found no evidence of any increase in the incidence of HBV infection with genotype A in the children.…”

Section: Discussioncontrasting

confidence: 55%

Transmission route and genotype of chronic hepatitis B virus infection in children in Japan between 1976 and 2010: A retrospective, multicenter study

Komatsu

Inui

Fujisawa

et al. 2014

Hepatology Research

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Section: Discussioncontrasting

confidence: 55%

Transmission route and genotype of chronic hepatitis B virus infection in children in Japan between 1976 and 2010: A retrospective, multicenter study

Komatsu

Inui

Fujisawa

et al. 2014

Hepatology Research

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“…Infection with HBV genotype A is associated with increased replication and high concentration of HBV-DNA in body fluids of HBV carriers, which may lead to an increased risk of horizontal transmission. 60,61 HBV genomic heterogeneity may also play an important role in HBV intrauterine infection and certain mutations in preS1 region, preS2 region and S region might infect fetuses more readily. 62 In south Asia, the horizontal transmission is likely occurring at a younger age group.…”

Section: Risk Factors and Transmission In High-risk Personsmentioning

confidence: 99%

Tackling the Hepatitis B Disease Burden in India

Puri

2014

Journal of Clinical and Experimental Hepatology

119

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Globally, approximately 240 people have been infected worldwide with hepatitis B Virus (HBV). India has approximately HBV carrier rate of 3.0% with a high prevalence rate in the tribal population. With a population of more than 1.25 billion, India has more than 37 million HBV carriers and contributes a large proportion of this HBV burden. While horizontal transmission in childhood appears to be a major route of transmission, the role of vertical transmission is probably underestimated. Blood transfusion and unsafe therapeutic injections continue to be important modes of transmission of HBV. There is a need for large field studies to better understand HBV epidemiology and identify high prevalence areas, and public health measures to prevent disease transmission and decrease the burden of the disease. ( J CLIN EXP HEPATOL 2014;4:312-319)

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“…If confirmed, effort can be made to place these patterns in hepatitis B transmission predicting models. Although vaccination is an effective protective method for hepatitis B infection, the induced immunity may diminish through decades (11). Other protective methods should be discovered and introduced to improve global efforts and reduce burden of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…The coverage of vaccine is not complete, and many high risk populations are not vaccinated (2) .Even in vaccinated populations, the long term protective effect of the HBV vaccine is not clear, and immunity may diminish after a few decades or when immune system is weakened due to other health conditions (10) or when some of the HBV subtypes are present (11). Discovering hidden patterns in transmission of Hepatitis B virus can be a start point in developing techniques to reduce transmission of the infection.…”

Section: Introductionmentioning

confidence: 99%

Lower Intrafamilial Transmission Rate of Hepatitis B in Patients With Hepatitis D Coinfection: A Data-Mining Approach

et al. 2013

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BackgroundThe presence of an infected family member significantly increases the risk of HBV transmission, but many socio-demographic and viral characteristics of family members affect the transmission rate.ObjectivesIn this study, we have used data mining techniques to investigate the impact of different variables in intrafamilial transmission of HBV infection.Patients and Methodsdemographic information, viral markers, and medical history of 330 patients with chronic hepatitis B and their offspring attending a referral center in Tehran were collected. Data-mining techniques were administered to detect patterns.ResultsThe overall transmission rate was 15.7% (5.4% and 27.3% for male and female index cases respectively). In female patients, HBe Ag positively affected the transmission rate (49% vs. 23.4%). There was a dominant change in transmission rate of female patients with negative results for Hbe Ag with HDV coinfection, where the transmission rate changed from 25% in patients with negative results for HDV Ab to 5% in those with positive results. In Hbe Ag negative male index cases, the transmission rate was 1.3% in cases with positive results for HDV Ab compared to 7% in those with negative findings. The overall transmission rate was statistically different between patients with positive and negative results for HDV Ab (P = 0.016).ConclusionsThere is a minor but consistent pattern change in the presence of HDV infection which reduces familial transmission of HBV, especially in female patients with negative results for HBe Ag.

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Does the spread of hepatitis B virus genotype A increase the risk of intrafamilial transmission in Japan?

Cited by 9 publications

References 23 publications

Transmission route and genotype of chronic hepatitis B virus infection in children in Japan between 1976 and 2010: A retrospective, multicenter study

Transmission route and genotype of chronic hepatitis B virus infection in children in Japan between 1976 and 2010: A retrospective, multicenter study

Tackling the Hepatitis B Disease Burden in India

Lower Intrafamilial Transmission Rate of Hepatitis B in Patients With Hepatitis D Coinfection: A Data-Mining Approach

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