Does the rs9939609 FTO gene polymorphism affect fat percentage? A meta-analysis

Dahka, Samaneh Mirzaei; Vahid, Farhad; Bourbour, Fatemeh; Badeli, Mostafa; Javadikooshesh, Sepehr; Jarrahi, Seyed Alireza Mosavi; Akbari, Mohammad Esmail; Tabesh, Ghasem Azizi; Montazeri, Fateme; Hassanpour, Ayemeh; Doaei, Saeid

doi:10.1080/13813455.2020.1773861

Cited by 10 publications

(9 citation statements)

References 23 publications

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“… 39 Remarkably, it has been reported that carriers of the A allele of FTO rs9939609 polymorphism had a higher body fat percentage (BF%). 40 Timpson et al in a cohort study reported that people with the rs9939609 minor allele had a higher intake of fat than those with the TT genotype. 41 Furthermore, we found in previous studies that homozygotes for the rs9939609 risk allele (A) had higher serum leptin compared to the TT genotype.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that higher omega‐6 fatty acids intake was associated with increased risk of BC in women 39 . Remarkably, it has been reported that carriers of the A allele of FTO rs9939609 polymorphism had a higher body fat percentage (BF%) 40 . Timpson et al in a cohort study reported that people with the rs9939609 minor allele had a higher intake of fat than those with the TT genotype 41 .…”

Section: Discussionmentioning

confidence: 99%

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The effects of FTO gene rs9939609 polymorphism on the association between breast cancer and dietary intake

Doaei

Abdollahi

Mohseni

et al. 2022

J Cellular Molecular Medi

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Breast cancer (BC) is the leading cause of cancer‐related deaths in females worldwide and is related to genetic and environmental factors. Dietary components may strongly influence the risk of BC. A possible association was also reported between the fat mass and obesity‐associated (FTO) single‐nucleotide polymorphisms (SNPs) and BC. This study aimed to investigate the impact of FTO rs9939609 polymorphism on the association between BC and dietary intake. This study was conducted on 180 women with BC as the case group and 360 healthy women as the control group. The dietary intakes were assessed by a valid 168‐item food frequency questionnaire (FFQ). The FTO gene was genotyped for rs9939609 polymorphism. After adjusting the confounding variables, there was no significant association between dietary intake and BC in individuals without risk allele. A positive association between dietary intake of omega‐6 fatty acids and BC was found only in individuals with risk allele of FTO gene (OR: 1.31, 95% CI: 1.08–1.60, p: 0.006). FTO gene risk allele may influence the effect of diet on breast cancer risk. Further studies are needed to assess the possible effects of the FTO genotype on the association between BC risk and dietary components.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The effects of FTO gene rs9939609 polymorphism on the association between breast cancer and dietary intake

Doaei

Abdollahi

Mohseni

et al. 2022

J Cellular Molecular Medi

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“…15 For example, the carriers of the A allele of FTO rs9939609 polymorphism have a higher body fat percentage. [16][17][18] The homozygotes for the FTO rs9939609 risk allele (A) had higher serum leptin, 16 and the amounts of dietary calorie, carbohydrate and fat intake were associated with FTO genotype. 17 The obesity-related SNPs reside in the first intron of FTO, and they may not only impact FTO but mediate their obesity effects via nearby genes such as IRX3.…”

Section: Introductionmentioning

confidence: 99%

“…Many studies have also reported a significant association between FTO genotype and anthropometric measurements such as body mass index (BMI), body weight and body composition 15 . For example, the carriers of the A allele of FTO rs9939609 polymorphism have a higher body fat percentage 16‐18 . The homozygotes for the FTO rs9939609 risk allele (A) had higher serum leptin, 16 and the amounts of dietary calorie, carbohydrate and fat intake were associated with FTO genotype 17 .…”

Section: Introductionmentioning

confidence: 99%

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Interactions of anthropometric indices, rs9939609 FTO gene polymorphism and breast cancer: A case‐control study

Doaei

Bourbour

Rastgoo

et al. 2021

J Cellular Molecular Medi

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Contradictory results were reported on the effect of fat mass‐ and obesity‐associated (FTO) gene and anthropometric measurements on breast cancer (BC). This study aimed to assess the interactions between rs9939609 polymorphism of FTO gene, anthropometric indices and BC risk in Iranian women. This case‐control study was performed on 540 women including 180 women with BC and 360 healthy women in Tehran, Iran. Physical activity and dietary intakes were assessed by validated questionnaires. Data on sociodemographic and pathologic factors of the participants as well as their blood samples were collected. The rs9939609 FTO gene polymorphism was genotyped using the tetra‐primer amplification refractory mutation system‐polymerase chain reaction (T‐ARMS‐PCR). No significant association was found between BC and risk allele of FTO rs9939609 polymorphism after adjustments for the confounders. However, there was a significant association between rs9939609 polymorphism risk allele and BC risk in females with overweight, even after adjusting for age, family history of BC, abortion, BMI and the number of pregnancies (P < .05). The association was disappeared after further adjustments for lifestyle factors including smoking, alcohol consumption, calorie and macronutrients intake, and physical activity. The FTO gene polymorphism was associated with the risk of BC in overweight individuals. This association was influenced by environmental factors including diet, alcohol consumption and smoking. Future studies are required to confirm the association between the FTO gene and BC in overweight females and to identify the underlying mechanisms.

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Association of common genetic variants with body mass index in Russian population

Berseneva

Kovalenko²,

Vergasova³

et al. 2023

Eur J Clin Nutr

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Does the rs9939609 FTO gene polymorphism affect fat percentage? A meta-analysis

Cited by 10 publications

References 23 publications

The effects of FTO gene rs9939609 polymorphism on the association between breast cancer and dietary intake

The effects of FTO gene rs9939609 polymorphism on the association between breast cancer and dietary intake

Interactions of anthropometric indices, rs9939609 FTO gene polymorphism and breast cancer: A case‐control study

Association of common genetic variants with body mass index in Russian population

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