Interactions of anthropometric indices, rs9939609 FTO gene polymorphism and breast cancer: A case‐control study

Abstract

Contradictory results were reported on the effect of fat mass‐ and obesity‐associated (FTO) gene and anthropometric measurements on breast cancer (BC). This study aimed to assess the interactions between rs9939609 polymorphism of FTO gene, anthropometric indices and BC risk in Iranian women. This case‐control study was performed on 540 women including 180 women with BC and 360 healthy women in Tehran, Iran. Physical activity and dietary intakes were assessed by validated questionnaires. Data on sociodemographic and pathologic factors of the participants as well as their blood samples were collected. The rs9939609 FTO gene polymorphism was genotyped using the tetra‐primer amplification refractory mutation system‐polymerase chain reaction (T‐ARMS‐PCR). No significant association was found between BC and risk allele of FTO rs9939609 polymorphism after adjustments for the confounders. However, there was a significant association between rs9939609 polymorphism risk allele and BC risk in females with overweight, even after adjusting for age, family history of BC, abortion, BMI and the number of pregnancies (P < .05). The association was disappeared after further adjustments for lifestyle factors including smoking, alcohol consumption, calorie and macronutrients intake, and physical activity. The FTO gene polymorphism was associated with the risk of BC in overweight individuals. This association was influenced by environmental factors including diet, alcohol consumption and smoking. Future studies are required to confirm the association between the FTO gene and BC in overweight females and to identify the underlying mechanisms.

Association between the FTO SNP rs9939609 and Metabolic Syndrome in Chilean Children

“…It has been observed that the association between the rs9939609 SNP and MetS is higher in subjects with a low level of physical activity [65]. However, evidence shows that performing physical activity can significantly attenuate the rs9939609 SNP of the FTO gene [66][67][68] and other genes associated with obesity and metabolic alterations [69].…”

The association between fat mass and obesity‐associated (FTO) genotype and serum vitamin D level in breast cancer patients

“… 25 A recent case‐control study by Doaei et al, found no significant relationship between BC and the risk allele (A) of FTO rs9939609 in participants with normal BMI. 26 in contrast with Zhao et al indicating the association of FTO rs9939609 with BC risk. 27 Mozaffarizadeh et al reported that rs9939609 FTO gene polymorphism was significantly associated with BC risk in overweight individuals.…”

The effects of FTO gene rs9939609 polymorphism on the association between breast cancer and dietary intake

“…A case–control study was conducted on 180 patients with cancer as the case group and 360 healthy individuals as the control group. The required sample size was estimated based on the odds ratio (OR) of the previous studies 31 . According to inclusion criteria, the participants were selected among women referred to the Cancer Research Center of Shohadaye Tajrish Hospital in Tehran, Iran.…”

“…The required sample size was estimated based on the odds ratio (OR) of the previous studies. 31 According to inclusion criteria, the participants were selected among women referred to the Cancer Research Center of Shohadaye Tajrish Hospital in Tehran, Iran. Individuals whose blood samples were collected at the beginning of the study were eligible to participate in the study according to the inclusion and exclusion criteria.…”