Does the platelet‑to‑lymphocyte ratio have a prognostic effect in patients with myelodysplastic syndrome?

Abstract

INTRODUCTION: Myelodysplastic syndromes (MDS) include various hematologic abnormalities characterized by chronic cytopenia due to disruption in cellular differentiation. This study aims to evaluate the prognostic value of PLR in patients with MDS. MATERIAL AND METHODS: Clinical-laboratory fi ndings and the results of bone marrow biopsies of MDS patients before treatment were recorded. p value of < 0.05 was considered statistically signifi cant. SPSS version 20.0 was used for statistical analysis. RESULTS: The study included 62 patients with median follow-up time of 62.8 ± 4.5 months and median age of 68.5 years. In 13 patients, acute leukemia was transformed. In these subjects, a PLR cutoff level of 46 was established for mortality (p = 0.015). We found a signifi cant relationship between PLR and multilineage series with the presence of dysplasia (p = 0.017). The survival analysis showed a decreased survival in cases with dysplasia in two and/or more series, transformation into acute leukemia, and thrombocytopenia. CONCLUSION: Our study demonstrated that there was a relationship between PLR and MDS with multilineage dysplasia (mld-MDS). PLR is investigated as an infl ammatory fi nding in various hematologic malignancies. Further studies investigating the value of PLR in MDS are needed to determine whether PLR may be a marker of bone marrow dysplasia grading (Tab. 2, Fig. 4, Ref. 32).

Platelet‐to‐lymphocyte ratio and absolute monocyte count have prognostic potential in primary myelodysplastic neoplasms

“…18 A higher PLR (≥22.4) was suggested as an inferior predictor for OS in a study by Shi et al 19 that included 213 patients with MDS. Yikilmaz et al 20 reported that a decreased PLR (≤46) was associated with MDS subtypes featuring multilineage dysplasia in univariate analyses but was not associated with OS in a cohort of 62 MDS patients. In our study, we concluded that a higher PLR ≥ 213.2 was an independent risk factor for OS in MDS.…”

Prognostic Role of Cell Blood Count in Chronic Myeloid Neoplasm and Acute Myeloid Leukemia and Its Possible Implications in Hematopoietic Stem Cell Transplantation

“…Notably, high levels of ACL were associated with a specific subgroup of MDS patients with ring sideroblasts, known to have a good prognosis [ 69 ]. MDS of multilineage dysplasia, on the other hand, was associated with a lower level of PLR [ 70 ]. However, lymphocyte counts were low in therapy-related MDS.…”