We could not find any relationship between Bcl-2, c-Myc and EBER-ISH positivity and the low/high IPS groups in cHL. New studies with larger series are needed in which more precise cut-off values are used and clinically and biologically heterogeneous groups of cHL patients are determined more clearly.

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Summary Background This study aimed to show the status of thioldisulphide homeostasis in essential thrombocytosis patients, which is known to play a role in platelet function. Methods The study included 27 ET patients and a control group of 36 healthy subjects. Serum total (–SH + –S–S–) and native (–SH) thiol levels were measured in all subjects using an automatic method. Results Age and gender distribution were similar in both groups. Compared with the control group, in the ET group, there were increased native thiol and total thiol levels (p = 0.001, p = 0.046). There was no correlation between thiol, total thiol and disulphide ratios with Jak2 mutation, hemorrhage and thrombosis. A positive correlation was determined between thrombosis and thiol disulphide homeostasis (p = 0.058). The study results showed that thiol-disulphide homeostasis shifted to the proliferative side in ET, in which ineffective erythropoiesis was predominant. It is also known that platelets are more active in ET cases and thiol disulphide balance is important in platelet function. Conclusions This result suggests that thrombotic complications may be reduced if the formation is achieved of mechanisms (oxidation mechanisms) that will trigger the increase of disulphide groups. However, more extensive research is needed on this subject.

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Vitamin B 1 is only synthesized by microorganisms in nature and thus, is obtained by human beings through their diet. Since the most important source of vitamin B 1 is animal proteins, vegetarians may lack suicient quantities of this vitamin in their diets. Vitamin B 1 deiciency may stem from a lower dietary intake, an autoimmune issue related to intrinsic factors or gastrointestinal system diseases resulting in vitamin B 1 malabsorption. The most important symptoms and indings of severe vitamin B 1 deiciency are anemia and neurological problems. If it is not treated, anemia symptoms and neurological disturbances resulting in spinal cord and cerebral cortex demyelination may emerge. Vitamin B 1 deiciency is one of the most frequent vitamin deiciencies worldwide. This deiciency is a highly important public health issue because of its serious complications if it is not detected and treated appropriately, although its treatment is very simple. Epidemiological studies in this ield are, therefore, of great value. Most of the studies on this subject have been examined vitamin status of the general population. The research generally contains to the national or provincial populations data. Nevertheless, the few data are not fully representative in the general population. Determining risk factors and at-risk groups, and educating them about vitamin B 1 deiciency and proper diet would prevent the irreversible complications of this type of deiciency. The goal of this study is to review epidemiological studies related to vitamin B 1 deiciency and to point out the importance of identifying and treating it.