Does the mean platelet volume have any importance in patients with acute pulmonary embolism?

Ermiş, Hilal; Yücel, Neslihan; Gülbaş, Gazi; Türkkan, Sinan; Aytemur, Zeynep Ayfer

doi:10.1007/s00508-013-0380-9

Cited by 19 publications

(20 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, platelet activation in patients after an acute thromboembolic event, determines higher MPV values, that are signifi-cantly associated with the severity of the VTE 1 . However, we have not found evidence of the association between the MPV and mortality in patients with VTE 1 .…”

contrasting

confidence: 86%

“…Buenos aires, argentina. 2 T hromboembolic disease (VTE) whose clinical manifestations are pulmonary embolism (PE) and deep vein thrombosis (DVT) is a prevalent disease with severe complications in the short and long run, and a high potential for morbidity and mortality 1 . The PE is responsible for 5-10% of hospital mortality in general 2 , and can be increased up to 30% if not diagnosed and treated early, adding a 5% mortality caused by recurrence 3 .…”

mentioning

confidence: 99%

“…Some studies have shown that the high values of ProBNP, serum troponins, hyponatremia and lactate are associated with an increased mortality in patients with a thromboembolic event, just as a right ventricular dysfunction and the coexistence of PE with DVT 2,4,5 . The platelet size, measured as mean platelet volume (MPV), is a marker of platelet reactivity 5,6 , where larger platelets are hemostatically more reactive than normal sized platelets 1,5 . The association was demonstrated with platelet activity indicators, including the expression of glycoprotein Ib, glycoprotein receptor IIb/IIIa and the expression of higher levels of P-selectin 6,7 .…”

mentioning

confidence: 99%

See 2 more Smart Citations

Mean platelet volume as a prognostic factor for venous thromboembolic disease

et al. 2019

View full text Add to dashboard Cite

Background: Mean platelet volume (MPV) is a risk factor for cardiovascular and inflammatory diseases. Aim: To evaluate the association between high MPV and 90-day mortality after an episode of venous thromboembolism (VTE). Material and Methods: Retrospective cohort of 594 patients with a median age of 73 years (58% women) with a first episode VTE, included in an institutional Thromboembolic Disease registry between 2014 and 2015. MPV values were obtained from the automated blood cell count measured at the moment of VTE diagnosis. Volumes ≥ 11 fL were classified as high. All patients were followed for 90 days to assess survival. Results: The main comorbidities were cancer in 221 patients (37%), sepsis in 172 (29%) and coronary artery disease in 107 (18%). Median MPV was 8 fl (8-9), brain natriuretic peptide 2,000 pg/ml (1,025-3,900) and troponin 40 pg/ml (19.5-75). Overall mortality was 20% (121/594) during the 90 days of follow-up. Thirty three deaths occurred within 7 days and 43 within the first month. The loss of patients from follow-up was 5% (28/594) at 90 days. Mortality among patients with high MP was 36% (23/63). The crude mortality hazard ratio (HR) for high MPV was 2.2 (95% confidence intervals (CI) 1.4-3.5).When adjusted for sepsis, oncological disease, heart disease, kidney failure and surgery, the mortality HR of high MPV was 2.4 (CI95% 1.5-3.9) in the VTE group, 2.3 (CI95% 1.5-4.4) in the deep venous thrombosis group, and 2.9 (CI95% 1.6-5.6) in the pulmonary embolism group. Conclusions: High MPV is an independent risk factor for mortality following an episode of VTE.

show abstract

contrasting

confidence: 86%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Mean platelet volume as a prognostic factor for venous thromboembolic disease

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Nevertheless, they reported higher MPV levels in nonsurviving PE patients compared to surviving patients (18).…”

Section: Discussionmentioning

confidence: 92%

“…Right ventricle enlargement with increased pulmonary artery pressure can be accepted as hemodynamic indicators and both of them can show the the severity of pulmonary arterial vasculature thrombotic occlusion (18). Moreover, platelet activation correlates with the RV dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Does platelet indices play a role in the distinction of pulmonary embolism clinical forms?

Telo¹,

Kırkıl²,

Kaman³

et al. 2017

J Turgut Ozal Med Cent

View full text Add to dashboard Cite

Aim: The aim of this study is to investigate the changes in platelet indexes, including mean platelet volume (MPV), platelet distribution width (PDW) and platelet count (PC), in patients with acute pulmonary embolism (PE), in addition to evaluating the diagnostic value in clinical forms. Material and methods: The study consisted of 84 patients with PE and the control group consisted of 40 healthy subjects. PE patients were divided into two groups in accordance with the clinical forms as 60 submassive and 24 nonmassive. The differences in platelet count, MPV, PDW, PC, D-dimer, and other indicators were analyzed between the two groups. Venous peripheral blood samples to measure the MPV, PDW and PC were acquired on admission. Results: MPV levels were found to be statistically higher in the submassive group compared to the nonmassive group and the control group (p<0.01 and p<0.001, respectively). PDW levels were found to be statistically higher in the submassive group compared to the non-massive group and control group (p=0.027 and p<0.001, respectively). PC was significantly lower in the submassive group compared to the non-massive group and control group (p=0.022 and p<0.001, respectively). It was determined that a positive correlation existed between the MPV and right ventricular diameter (RVD) (r=0.27, p<0.01). Conclusion: High MPV and PDW levels and low PC may be indicators of the severity of acute PE. Also, the correlation between the MPV and RVD suggests that MPV can be used as a marker of right ventricular function.

show abstract