Does the fibrinogen/albumin ratio predict the prognosis of pregnancies with abortus imminens?

Usta, Ceyda Sancaklı; Ati̇k, Tuğba Kula; Ozcaglayan, Ruhsen; Bülbül, Çağla Bahar; Camili, Figen E.; Adalı, Ertan

doi:10.15537/smj.2021.42.3.20200695

Cited by 2 publications

(3 citation statements)

References 30 publications

(65 reference statements)

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“…FAR is a ratio of fibrinogen and albumin, which is generated at no extra cost when biochemistry and coagulation function tests are performed in routine antenatal examinations. Multiple studies have suggested that elevated levels of FAR are associated with many diseases, such as abortus imminent, [ 16 ] systemic lupus erythematosus, [ 17 ] acute coronary syndrome, [ 24 ] rheumatoid arthritis [ 25 ] and ankylosing spondylitis, [ 26 ] which are associated with an inflammatory state. Hence, it has been concluded that FAR may be a better indicator for many systemic inflammation diseases.…”

Section: Discussionmentioning

confidence: 99%

“…[ 14 , 15 ] Since preeclampsia is also associated with some degree of inflammatory burden, [ 4 ] it is reasonable to study other inflammatory markers in preeclampsia. In addition, fibrinogen to albumin ratio (FAR) is a new inflammatory marker and has been proven to have excellent predictive value for abortus imminent, [ 16 ] systemic lupus erythematosus, [ 17 ] and ascending aortic aneurysm. [ 18 ] However, there has been no reliable research on whether FAR can predict PE or evaluate its severity.…”

Section: Introductionmentioning

confidence: 99%

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Fibrinogen to albumin ratio, a novel serum indicator for evaluating the severity of preeclampsia: A single-center retrospective study

et al. 2023

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Preeclampsia (PE) is a disorder that affects approximately 5% to 10% of pregnant women. Timely and accurate identification of PE and assessment of its severity are crucial. Therefore, it is necessary to develop predictive indicators which are easily measured in routine antenatal examinations to enable the early detection of PE and assess its severity. We designed a single-center retrospective study in our daily work to assess whether the serum levels of fibrinogen to albumin ratio (FAR), fibrinogen (Fib), albumin (ALB), prothrombin time, calcium (Ca), activated partial thrombin time, creatinine (Cr), D-dimer(D-D), platelet, white blood cell, neutrophil, and lymphocyte counts could help in assessing PE and evaluating its severity. Our findings showed that the serum levels of FAR, Cr, Fib, and D-D were significantly higher in the severe preeclampsia group (sPE) compared with the control and mild preeclampsia groups, whereas the levels of ALB and Ca were significantly lower in sPE patients. In addition, no differences were found between the control and PE groups in terms of prothrombin time, activated partial thrombin time, platelet, white blood cell, neutrophils, and lymphocytes counts. Furthermore, FAR is a novel and better indicator for evaluating the severity of PE, which has not been reported before. And it is an independent risk factor for the development of sPE. In conclusion, the serum levels of FAR, Cr, D-D and Fib were positively correlated with PE, whereas ALB and Ca were negatively correlated with PE severity, which might be valuable in evaluating the severity of PE. FAR proved to be a feasible diagnostic marker for sPE with sensitivity and specificity comparable to those of ALB and Fib.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fibrinogen to albumin ratio, a novel serum indicator for evaluating the severity of preeclampsia: A single-center retrospective study

et al. 2023

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“…attributed to the changes in nutritional status; furthermore, hypoalbuminemia represents a chronic inflammatory state caused by malnutrition (33,34). Likewise, FAR has been proven to be a more powerful inflammatory-based prognostic predictor of overall survival than other single prognostic markers (35)(36)(37); compared with healthy pregnancies, FAR was considered to be an independent risk factor for predicting spontaneous abortion, and increased FAR levels were considered to be related to the thrombotic process in recurrent abortion (38,39). BUN/Cr is an important indicator to evaluate acute renal injury and gastrointestinal hemorrhage, and a low BUN/Cr level is associated with higher risks of total and ischemic stroke (40)(41)(42).…”

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confidence: 99%

Establishment and validation of a predictive nomogram for gestational diabetes mellitus during early pregnancy term: A retrospective study

Zhu²,

Wang³

et al. 2023

Front. Endocrinol.

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ObjectiveThis study aims to develop and evaluate a predictive nomogram for early assessment risk factors of gestational diabetes mellitus (GDM) during early pregnancy term, so as to help early clinical management and intervention.MethodsA total of 824 pregnant women at Zhongnan Hospital of Wuhan University and Maternal and Child Health Hospital of Hubei Province from 1 February 2020 to 30 April 2020 were enrolled in a retrospective observational study and comprised the training dataset. Routine clinical and laboratory information was collected; we applied least absolute shrinkage and selection operator (LASSO) logistic regression and multivariate ROC risk analysis to determine significant predictors and establish the nomogram, and the early pregnancy files (gestational weeks 12–16, n = 392) at the same hospital were collected as a validation dataset. We evaluated the nomogram via the receiver operating characteristic (ROC) curve, C-index, calibration curve, and decision curve analysis (DCA).ResultsWe conducted LASSO analysis and multivariate regression to establish a GDM nomogram during the early pregnancy term; the five selected risk predictors are as follows: age, blood urea nitrogen (BUN), fibrinogen-to-albumin ratio (FAR), blood urea nitrogen-to-creatinine ratio (BUN/Cr), and blood urea nitrogen-to-albumin ratio (BUN/ALB). The calibration curve and DCA present optimal predictive power. DCA demonstrates that the nomogram could be applied clinically.ConclusionAn effective nomogram that predicts GDM should be established in order to help clinical management and intervention at the early gestational stage.

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Does the fibrinogen/albumin ratio predict the prognosis of pregnancies with abortus imminens?

Cited by 2 publications

References 30 publications

Fibrinogen to albumin ratio, a novel serum indicator for evaluating the severity of preeclampsia: A single-center retrospective study

Fibrinogen to albumin ratio, a novel serum indicator for evaluating the severity of preeclampsia: A single-center retrospective study

Establishment and validation of a predictive nomogram for gestational diabetes mellitus during early pregnancy term: A retrospective study

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