Does the Female Life Span Exceed That of the Male

Lints, F.A.; Bourgois, M.; Delalieux, A.; Stoll, Jane; Lints, C.V.

doi:10.1159/000213136

Cited by 81 publications

(31 citation statements)

References 22 publications

(37 reference statements)

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“…This was suspected by Lamb [8] and has recently been demonstrated by Lints et al [15], Another secondary result is more sur prising. Indeed, in contrast to what has been shown quite a few times [reviews in ref.…”

Section: Discussionmentioning

confidence: 76%

Spontaneous Locomotor Activity and Life Span

Lints¹,

Bourg²,

Lints³

1984

Gerontology

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The spontaneous locomotor activity and life span of approximately 600 individuals of both sexes and of three widely different genotypes of Drosophila melanogaster have been measured. Neither at the individual nor at the populational level could a significant correlation between spontaneous locomotor activity and life span be found. The results are discussed in relation with Pearl’s [The rate of living, London University Press, London 1928] rate of living theory. That theory has been tested in relation with environmental temperature, oxygen consumption and activity. It is shown that the theory has received no definite confirmation until now.

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Section: Discussionmentioning

confidence: 76%

Spontaneous Locomotor Activity and Life Span

Lints¹,

Bourg²,

Lints³

1984

Gerontology

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“…These results confirm the studies of Lints and Bermejo. 27,32) In life span parameter, Fraxetin treatment shows a beneficial effect, both for females and males, with a maximum average longevity for F-0 groups. Under induced stress conditions, the best treatments were in males: F-2 treatment for longevity, F-0 treatment for average longevity and F-4 treatment for life span, whereas in females, the highest average longevity was reached in the F-2 group.…”

Section: Resultsmentioning

confidence: 96%

Antioxidant Activity of Fraxetin: In Vivo and ex Vivo Parameters in Normal Situation versus Induced Stress.

Fernández-Puntero

Barroso

Iglesias

et al. 2001

Biological & Pharmaceutical Bulletin

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Free radicals generation during cellular metabolism is the main cause of molecular damage underlying the aging process.1) Several authors assert that induced stress enhanced this process, because the deleterious effects of free radicals are progressive and accumulative. [2][3][4] The effect of free radicals in the Drosophila melanogaster life span has been amply studied. 5,6) Various authors have demonstrated a decrease in negative geotaxis in aging, so microgravity is an adequate measure of the vital capacity of flies. [7][8][9] This investigation establishes the influence of stress provoked by the assay of microgravity (flying capacity reduction) in the life span of flies. Therefore, we have evaluated the survival values of the population submitted to an assay of microgravity during its development until the death of the last individual.Their life expectancy is relative to their basal metabolic rate 10) and can be altered by diet, temperature, light and exposure to antioxidants. These conditions affect the level of free radicals.11) The effects of exogenous antioxidant administration on the prevention of diseases was proposed by Gerschman,12) and these beneficial effects could influence the life span.13) This study examined the effect of the exogenous administration of a natural product, such as Fraxetin, on the life span of Drosophila melanogaster, and on its vital capacity.On the other hand, we evaluated the biochemical parameters associated with the free radical theory. Reduced forms of glutathione are capable of reducing various free radicals, 14) so the oxidative status could be evaluated by measuring this natural antioxidant. Another parameter affected by the induced stress is lipid peroxidation. An increase in lipid peroxides is usually taken as an estimator of oxidative stress. 15,16) So, both parameters could establish oxidative status, but an increase in GSH content does not always correspond with the decrease in lipid peroxidation, since both parameters can be produced by different mechanisms. This feature indicates the complex mechanisms implicated in oxidative stress. MATERIALS AND METHODS AnimalsOregon R Drosophila fruit flies were maintained in an environmentally controlled incubator at 25°C on a 12/12 h light/dark cycle, with constant humidity. Flies were fed a free PUFA diet, based on an agar (1.1%) culture medium containing sugar (7.5%), corn flour (3.5%) and the yeast Sacharomyces cerevisiae (7.5%). The treatment was introduced in the daily diet at different ages of the animal model, following the model proposed by Miquel. 17) In the case of the treatment groups, Fraxetin was directly incorporated on the culture medium, so the culture medium of the treatment groups was homogenous concentration of 1 mM of Fraxetin. We did not use an organic solvent to solve Fraxetin, and there was no influence of solvents on oxidative stress or life span in our research. The treatment groups were the Control (without treatment, as comparation), F-0 (Fraxetin treatment from the 1st day, 1 mM), F-1 (Fraxetin ...

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“…Results from fitting procedures performed on rotifers [ 10], flies [11], rats [ 12] and horses [4,13] The present model has also been tested by fitting some particular survivorship kinetics, in order to gain information about its extent of applicability. In figure 4 and table 2 two sets of data are reported derived from kinetics of male flies grown, by pairs, (Id1 , 1 $) either in bottles (250 cm3) or in vials (50 cm3) [11 Table 1.…”

Section: Examples and Discussionmentioning

confidence: 99%

Modelling Survivorship Kinetics: A Two-Parameter Model

1992

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A mathematical model of survivorship kinetics is presented. It takes into account both deterministic and stochastic aspects of survival curves. Earlier reports [Piantanelli: Arch Gerontol Geriatr 1986;5:107–118; Piantanelli: Ann NY Acad Sci 1988; 521:99–109] described a model capable of making distinct predictions on the mean and standard deviation of an index of physiological function, fitting data even in the tail of survivorship curves, and accounting for the selection of the cohort at advanced ages. However, it contains four parameters whose biological interpretation is unclear. In the present paper we propose a modification of the model which maintains the main characteristics of the previous one and, in addition, results in two significant improvements. First, the number of free parameters is reduced to only two, making much easier both their estimation and interpretation, particularly when the model is applied to data from various animal groups manipulated in different ways. Second, it is possible to relate the parameters to well-defined deterministic and stochastic factors: specifically, a deterministic component describing the environmental and genetic influence on physiological functions, and a stochastic component representing the fluctuating interactions of the living organism and its environment.

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Does the Female Life Span Exceed That of the Male

Cited by 81 publications

References 22 publications

Spontaneous Locomotor Activity and Life Span

Spontaneous Locomotor Activity and Life Span

Antioxidant Activity of Fraxetin: In Vivo and ex Vivo Parameters in Normal Situation versus Induced Stress.

Modelling Survivorship Kinetics: A Two-Parameter Model

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