Does tantalum exhibit any intrinsic antimicrobial or antibiofilm properties?

Harrison, Patrick L.; Harrison, T; Stockley, I; Smith, Thomas J.

doi:10.1302/0301-620x.99b9.bjj-2016-1309.r1

Cited by 44 publications

(33 citation statements)

References 17 publications

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“…Rowan el al [38]., in a comparative study of reconstruction with trabecular metal vs. impaction grafting, points out that caution should be exercised with the latter in patients healing from infection. Trabecular metal can decrease the probability of infection and thus, from a clinical standpoint, is associated with a lower probability of infection [39], but this could not be demonstrated in in vitro experiments [40].…”

Section: Discussionmentioning

confidence: 94%

Bone impaction grafting with trabecular metal augments in large defects in young patients: unravelling a new perspective in surgical technique

Torre-Escuredo

Gómez-García

Álvarez-Villar

et al. 2020

BMC Musculoskelet Disord

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Background: Acetabular reconstruction with bone impaction grafting in large defects has yielded conflicting results. Methods: This was a retrospective study of a case series of five patients with a young age (≤50 years) at the time of surgery who had large acetabular defects reconstructed by bone impaction grafting and trabecular metal augments. The mean follow-up was 79 months. We describe the surgical technique in detail. Results: Improvement was significant on the WOMAC and SF-36 scales (p < 0.05). The radiographs taken at the last follow-up examination showed no migration of the polyethylene cup (p = 0.31) or differences in the abduction angle (p = 0.27) compared to the radiographs from the immediate postoperative period. One patient presented two dislocation episodes as a complication. Conclusion: The combination of trabecular metal augments with the bone impaction grafting technique in young patients with large acetabular defects provides satisfactory results in the long term and restores the bone stock.

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Section: Discussionmentioning

confidence: 94%

Bone impaction grafting with trabecular metal augments in large defects in young patients: unravelling a new perspective in surgical technique

Torre-Escuredo

Gómez-García

Álvarez-Villar

et al. 2020

BMC Musculoskelet Disord

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“…[38], in a comparative study of reconstruction with trabecular metal vs. impaction grafting, points out that caution should be exercised with the latter in patients healing from infection. Trabecular metal can decrease the probability of infection and thus, from a clinical standpoint, is associated with a lower probability of infection [39], but this could not be demonstrated in in vitro experiments [40].…”

Section: Discussionmentioning

confidence: 94%

Bone Impaction Grafting with Trabecular Metal Augments in Large Defects in Young Patients: Unravelling A New Perspective in Surgical Technique

Torre-Escurero¹,

Gómez-González

Álvarez-Villar

et al. 2020

Preprint

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Background: Acetabular reconstruction with bone impaction grafting in large defects has yielded conflicting results. Methods: This was a retrospective study of a case series of five patients with a young age (≤50 years) at the time of surgery who had large acetabular defects reconstructed by bone impaction grafting and trabecular metal augments. The mean follow-up was 79 months. We describe the surgical technique in detail.Results: Improvement was significant on the WOMAC and SF-36 scales (p < 0.05). The radiographs taken at the last follow-up examination showed no migration of the polyethylene cup (p = 0.31) or differences in the abduction angle (p = 0.27) compared to the radiographs from the immediate postoperative period. One patient presented two dislocation episodes as a complication.Conclusion: The combination of trabecular metal augments with the bone impaction grafting technique in young patients with large acetabular defects provides satisfactory results in the long term and restores the bone stock.

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“…The theory is supported by the observation that implants with Ta(Tantalum), a transition metal that belongs to the same family with vanadium but is demonstrated to possess no intrinsic antibiofilm or antibacterial effects, have a much lower incidence of re-infection than traditional titanium materials in patients undergoing revised THA (total hip arthroplasty) due to IRI. The mainstream hypothesis of the antibacterial behaviour of tantalum relates to its stronger stimulation of osteogenesis than Ti materials and the resulting advantages in helping osteoblasts adhere to material surfaces, obliterate "dead space" and win the race for the surface [64]. As tantalum materials without intrinsic antibacterial effects are able to prevent infection in vivo, our nano-VO 2 films with simultaneous intrinsic antibacterial and osteogenic activities are predictably competent in the prophylaxis of infections in vivo.…”

Section: Discussionmentioning

confidence: 99%

Nano vanadium dioxide films deposited on biomedical titanium: a novel approach for simultaneously enhanced osteogenic and antibacterial effects

Guo

Zhou

Wang

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Vanadium is a trace element in the human body, and vanadium compounds have a promising future in biological and medical applications due to their various biological activities and low toxicity. Herein, a novel pure vanadium dioxide (VO) nanofilm was deposited on a substrate of biomedical titanium by magnetron sputtering. The antibacterial effect of VO against the methicillin-resistant Staphylococcus aureus (MRSA) was validated in vitro and in vivo. Moreover, the biocompatibility of VO and its osteogenic effects were systematically illustrated. A possible osteogenic mechanism involving the amelioration of highly reactive oxygen species (ROS) levels were investigated. According to the results of our present and previous studies, the simultaneous antibacterial and osteogenic effects of VO are attributed to its differential regulation of ROS levels in rat bone marrow mesenchymal stem cells (rBMSCs) and bacteria. This study is the first to report the simultaneous effects of VO on bactericidal and osteogenic activities through its differential modification of ROS activity in eukaryotic (rBMSCs) and prokaryotic (MRSA) cells. The findings in this work may yield a deeper understanding of the biological activities of vanadium compounds while also paving the way for the further investigation and application of VO in biological and medical materials.

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Does tantalum exhibit any intrinsic antimicrobial or antibiofilm properties?

Cited by 44 publications

References 17 publications

Bone impaction grafting with trabecular metal augments in large defects in young patients: unravelling a new perspective in surgical technique

Bone impaction grafting with trabecular metal augments in large defects in young patients: unravelling a new perspective in surgical technique

Bone Impaction Grafting with Trabecular Metal Augments in Large Defects in Young Patients: Unravelling A New Perspective in Surgical Technique

Nano vanadium dioxide films deposited on biomedical titanium: a novel approach for simultaneously enhanced osteogenic and antibacterial effects

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