Does tachyphylaxis occur in long‐term management of scalp seborrheic dermatitis with pyrithione zinc‐based treatments?

Abstract

No evidence for tachyphylaxis in SD/D treatment by PTZ-based shampoos was found. Compliance could explain the decreasing response rate seen over time; the solution is to choose an affordable therapeutic product that is effective long term without cosmetic trade-offs.

Dandruff and seborrheic dermatitis

“…Also, multiple genes for generation of peroxides were identified, making it likely that Malassezia are involved in damage to the hair shaft as well as the scalp. This hypothesis is also supported by recent work indicating that hair sampled from dandruff sufferers was less healthy that that isolated from nondandruff subjects (44).…”

“…This requires long-term use of an effective antidandruff product that is also cosmetically desirable and affordable. PTZ-based shampoos have been shown (44) to be effective over long periods of time without the risk of any physiological accommodation (tachyphylaxis) that could gradually reduce the benefits.…”

An overview of zinc and its importance in dermatology-Part II: The association of zinc with some dermatologic disorders

“…In this study a survey questionnaire was sent to 722 dermatologists in five countries. Their study showed that there was no evidence for tachyphylaxis in the treatment of SD with Zn pyrithione shampoo [7].…”

“…It has been reported that some patients with AA have significantly decreased serum levels of Zn [7,21], but its pathogenesis in these patients is unknown [22]. In a case-control study on 50 patients with AA, Bhat et al demonstrated that serum Zn levels were significantly decreased in patients whose disease was extensive, prolonged, and resistant to treatment, whereas serum Cu and Mg levels showed insignificant rises compared to the controls [27].…”

Επιδημιολογική Μελέτη Της Κατά Φύλο Και Ηλικίας Κατανομής Του Επιπολασμού Των Βλατιδολεπιδωδών Δερματοπαθειών Στην Ελλάδα

“…Η ΣΔ στο δέρμα ανταποκρίνεται στην τοπική χρήση αντιμυκητιασικών κετοκοναζόλη, μπιφοναζόλη και κυκλοπιροξικάμη και σε διαφορετικές μορφές όπως στην κρέμα, γέλη, αφρό και σαμπουάν Rebora, 2009, Stefanaki andKatsambas, 2010).Η ξηρά πιτυρίαση ανταποκρίνεται καλύτερα στο συχνό λούσιμο. Τα σαμπουάν που περιέχουν σαλικυλικό οξύ, πίσσα, σελήνιο, θείο, ψευδάργυρο είναι αποτελεσματικά και μπορούν να χρησιμοποιηθούν σε ένα εναλλασσόμενο πρόγραμμα(Kligman AM, 1974, Schwartz et al, 2009. Η κλειστή περίδεση με πίσσα ή έλαιο λουτρού μπορεί να βοηθήσει να μαλακώσει τα παχιά λέπια του τριχωτού της κεφαλής.…”