Does stress hyperglycemia affect mortality? Acute myocardial infarction – case control study

Cinar, Hayri; Avcı, Akkan; Gülen, Müge; Avcı, Begüm Şeyda; Cömertpay, Ertan; Satar, Salim

doi:10.5114/amsad.2019.87303

Cited by 17 publications

(15 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…High ARPG levels after AMI are common and play a role in predicting adverse events in DM and non-diabetic patients [2,16]. Especially during hospitalization, it is a strong predictable factors for fatal outcomes in patients with AMI [5,17]. But A/C glycemic ratio was reported to be a better predictor of in-hospital morbidity and mortality than glycaemia at admission [3].…”

Section: Discussionmentioning

confidence: 99%

The association between glucose-related variables and plaque morphology in patients with ST-segment elevated myocardial infarction

Liu

Wang

Cui

et al. 2020

Cardiovasc Diabetol

View full text Add to dashboard Cite

Background: Plaque rupture (PR) and plaque erosion (PE) are main causes of acute myocardial infarction with different demographic and histology characteristics and need different treatment strategy. PR and PE can be identified with optical coherence tomography (OCT) accurately, but convenient and effective noninvasive markers for them are rarely found. History of diabetes mellitus (DM) was reported to be a potential predictor of PR in ST-segment elevated myocardial infarction (STEMI) patients, but the predictive value of other glucose-related variables for it is still uncertain. Present study aimed to clear the relationship between some glucose-related variables and plaque morphology in patients with STEMI. Methods: We consecutively enrolled 872 STEMI patients and divided them into PR group (n = 616) and PE group (n = 256) based on OCT diagnostic criteria. The relationship of glucose-related variables, including random plasma glucose on admission (ARPG), glycosylated hemoglobin (HbA1c), post-PCI fasting plasma glucose (PFPG), DM history, glucose variable tendency (GVT) and the acute-to-chronic glycemic ratio (A/C), to the PR risk of STEMI patients was analyzed. The correlation between the glucose-related variables and plaque morphology was analyzed meanwhile. Results: Among the glucose-related variables, ARPG and GVT were confirmed to be independent predictors for PR after adjusting for other traditional risk factors in nondiabetic patients. The higher the ARPG level, the more PR risk the STEMI patients had. And high HbA1c and APPG were demonstrated to have a weak and positive correlation with lipid constituents and stenosis degree of culprit vessel. Conclusions: Compared to HbA1c, DM history, and some other glucose-related variables, ARPG and GVT were risk factors for PR in STEMI patients, especially those without DM. And high HbA1c and ARPG were positively correlated with the development of vulnerable plaque in culprit vessels. Trial registration Present study is a retrospective one and the population came from the EROSION study of our center previously. It was approved by the Ethics Committee of the Second Affiliated Hospital of Harbin Medical University (Approval reference number, KY2017-249), and all patients provided written informed consent prior to the inclusion in the study and the investigation conformed to the principles outlined in the Declaration of Helsinki.

show abstract

Section: Discussionmentioning

confidence: 99%

The association between glucose-related variables and plaque morphology in patients with ST-segment elevated myocardial infarction

Liu

Wang

Cui

et al. 2020

Cardiovasc Diabetol

View full text Add to dashboard Cite

show abstract

“…Internal Medicine Department, Assiut University Hospitals, Faculty of Medicine, Assiut University, Assiut 71511, Egypt. 2 Assuit University, Assuit, Egypt.…”

Section: Fundingmentioning

confidence: 99%

“…Admission hyperglycemia (AH) has been determined to inversely affect short-and long-term prognosis in patients with STEMI regardless of their diabetic state [2].…”

Section: Introductionmentioning

confidence: 99%

Unique role of admission hyperglycemia on myocardial infarction size and area at risk following an acute ST-elevation myocardial infarction

et al. 2020

View full text Add to dashboard Cite

Background Hyperglycemia can adversely affect patients with acute ST-elevation myocardial infarction (STEMI) in both diabetic and non-diabetic patients. The majority of the studies had investigated the impact of admission hyperglycemia (AH) on cardiovascular morbidity and mortality while, in ours, we entailed its impact on final infarction size (FIS) and more interestingly, on the area at risk (AAR), both were estimated by cardiac magnetic resonance (CMR) imaging. Results AH showed significant positive correlations to FIS and AAR. Moreover, AH group had higher summation of ST segment elevation (sum STE), more maximum ST segment elevation (max STE), higher echocardiographic wall motion score index (WMSI), higher CMR estimated WMSI, and lower segmental ejection fraction (EF). Multivariate analysis showed that AH was independently associated with increased FIS. Conclusion Current study showed an association between AH and large FIS in STEMI patients.

show abstract

“…Studies show that stress hyperglycemia is present in one of four hospitalized ACS patients, and it is found in 41% of elderly patients. Stress hyperglycemia can be used as a prognostic indicator in patients with AMI [28], [29] According to Marfella et al [30], patients with hyperglycemia had a larger infarct size compared with normoglycemic patients, and also, there is evidence that supports an association between ventricular desynchrony and blood glucose levels in patients with MI, and an association with early in-hospital mortality in patients with AMI [31].…”

Section: Mawmentioning

confidence: 99%

Added Value of Modified Anderson–Wilkins Acuteness Score in Prognostication of Patients with Acute Myocardial Infarction

Serafimov

Taravari

Shehu

et al. 2020

Open Access Maced J Med Sci

View full text Add to dashboard Cite

BACKGROUND: Electrocardiogram (ECG) signs on admission can serve as a prognostic marker in patients treated for myocardial infarction (MI). AIM: The aim of the study was to determine the predictive role of modified Anderson–Wilkins (MAW) ECG score of acuteness on the extent of myocardial injury, left ventricular (LV) remodeling, and clinical outcome in patients with acute MI. METHODS: Prospective, observational cohort study on patients treated for MI at the University Clinic for Cardiology. Subjects were analyzed for their demographic, clinical, ECG, LV functional, angiographic variables, course of treatment, and in-hospital outcome. MAW score was calculated for each patient. Patients were comparatively analyzed divided in two groups (score <3 and ≥3). RESULTS: One hundred fifty patients (70% males and 30% females), aged 60.9 years were included in the study. Sixty-eight patients had MAW score <3 (mean 1.7), and 82 had score ≥3 (mean 3.5), p>0.001. Patients with ST-segment elevation MI had OR 2.1 (p>0.000), and patients with multiple locations (excluding anterior) had OR 2.1 (p > 0.000) of having MAW score ≥3. They received mechanical reperfusion 1.9 (p = 0.032) times more often. High MAW score was associated with stress hyperglycemia (OR 2.1; p = 0.032); low potassium (OR 2.8; p = 0.032), lower creatinine (p = 0.050), and higher NT-proBNP (OR 2.5; p = 0.050). High MAW score was associated with decreased LV function and increased LV dimensions on the follow-up echocardiography (p = 0.050 and 0.012, respectively). CONCLUSION: ECG is an important prognostic tool in MI patients. ECG-derived MAW score demonstrates a strong correlation with stress hyperglycemia, potassium, creatinine, and natriuretic peptides level and can serve as an early marker of LV remodeling after MI.

show abstract

Does stress hyperglycemia affect mortality? Acute myocardial infarction – case control study

Cited by 17 publications

References 29 publications

The association between glucose-related variables and plaque morphology in patients with ST-segment elevated myocardial infarction

The association between glucose-related variables and plaque morphology in patients with ST-segment elevated myocardial infarction

Unique role of admission hyperglycemia on myocardial infarction size and area at risk following an acute ST-elevation myocardial infarction

Added Value of Modified Anderson–Wilkins Acuteness Score in Prognostication of Patients with Acute Myocardial Infarction

Contact Info

Product

Resources

About