Does statistical difference in the pre/post-quasi-experimental study mean the utility of multimodal educational intervention in targeted normoxia in critically ill trauma patients?

Does statistical difference in the pre/post-quasi-experimental study mean the utility of multimodal educational intervention in targeted normoxia in critically ill trauma patients?

“…Kuroda, Tsutsumi, and Banno for discussing these important issues regarding the careful interpretation of the results of our pre/post quasiexperimental study of targeted normoxia in critically ill trauma patients. 1,2 This study was designed to be a pilot study to evaluate a multimodal approach to targeted normoxia in critically ill trauma patients. As such, consideration of the limitations of such a study design and the associated conclusions is needed.…”

“…As Kuroda et al 2 note, one of the most obvious limitations of the pre/post quasiexperimental study design is the potential for unknown confounders to introduce bias into the results that might suggest a positive effect of the intervention. For example, we agree that it is possible that medical staff maturation and inherent pattern changes over time could influence the results such that a statistical difference in oxygenation patterns due to the intervention is not due solely to the multimodal intervention.…”

“…Finally, Kuroda et al 2 note concerns regarding the study description in ClinicalTrials.gov. Of note, the posted article version that the authors reviewed was an uncorrected preprint version, and the NCT study number was corrected during review of the galley proofs of the final article version.…”

Response to: “Does statistical difference in a pre/post quasiexperimental study mean utility of a multimodal education intervention in targeted normoxia in critically ill trauma patients?”

“…Kuroda, Tsutsumi, and Banno for discussing these important issues regarding the careful interpretation of the results of our pre/post quasiexperimental study of targeted normoxia in critically ill trauma patients. 1,2 This study was designed to be a pilot study to evaluate a multimodal approach to targeted normoxia in critically ill trauma patients. As such, consideration of the limitations of such a study design and the associated conclusions is needed.…”

“…We appreciate the opportunity to respond to this letter and thank Drs. Kuroda, Tsutsumi, and Banno for discussing these important issues regarding the careful interpretation of the results of our pre/post quasiexperimental study of targeted normoxia in critically ill trauma patients 1,2 . This study was designed to be a pilot study to evaluate a multimodal approach to targeted normoxia in critically ill trauma patients.…”