Does sexual intercourse improve pregnancy rates in gamete intrafallopian transfer?

Marconi, Guillermo; Auge, L.; Osés, R.; Quintana, Ramiro; Raffo, Fernanda G.E.; Young, E.

doi:10.1016/s0015-0282(16)60507-1

Cited by 33 publications

(10 citation statements)

References 4 publications

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“…Several, large, wellcontrolled studies have demonstrated an increased risk of premature birth, very low birth weight, complications during delivery and serious birth defects in pregnancies derived from IVF (Perri et al 2001, Hansen et al 2002, Schieve et al 2002, Wang et al 2002, Ochsenkuhn et al 2003. It is interesting to note a number of studies which have demonstrated a beneficial effect of SP exposure at or around the time of embryo transfer (ET) to improve pregnancy rates in women (Marconi et al 1989, Tremellen et al 2000. In addition to these causal studies, epidemiological evidence suggest that semen exposure in a partner specific manner can help to prevent pregnancy pathologies such as preeclampsia where placentation is thought to be suboptimal (KlonoffCohen et al 1989, Robillard et al 1995.…”

Section: Sp-induced Inflammation and Immune Modulation In Maternal Timentioning

confidence: 99%

A role for seminal plasma in modulating pregnancy outcomes in domestic species

Bromfield¹

2016

Reproduction

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Seminal plasma is a complex fluid produced by the accessory glands of the male reproductive tract. Seminal plasma acts primarily as a transport medium for sperm on its arduous journey through the male and then female reproductive tract following ejaculation. This spermatozoan expedition will hopefully result in the meeting of and resultant fertilization of an oocyte, perpetuating the genetic lineage of both sexes. Whereas seminal plasma has historically been perceived as only a transport medium providing a nutrient-rich fluid environment for sperm during this exchange of genetic material, new insights into a complex communication pathway between males and females has been unraveled in the past 30 years. This new research suggests seminal plasma as a method to promote early pregnancy success by modulating cellular and molecular adaptions of the maternal environment required to facilitate healthy, successful pregnancy outcomes. Whereas much work on this exciting new communication process has focused on mice and translation to human reproduction, here we review the current evidence in domestic species where artificial insemination in the absence of seminal plasma is routine. Improving artificial insemination in domestic species to optimize offspring health and productivity could have far-reaching impacts on agriculturally relevant species such as cattle, sheep, pigs and horses.Reproduction (2016) 152 R223-R232

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Section: Sp-induced Inflammation and Immune Modulation In Maternal Timentioning

confidence: 99%

A role for seminal plasma in modulating pregnancy outcomes in domestic species

Bromfield¹

2016

Reproduction

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“…More recently this work has been carried over into the human ART program. It has been shown that semen exposure around the time of embryo transfer increases the rates of embryo implantation and possible subsequent foetal development [5,115,116]. Bellinge et al has previously shown that seminal exposure as early as the time of oocyte retrieval can increase the incidence of pregnancy in women undergoing IVF [117].…”

Section: Seminal Plasma and Assisted Reproductionmentioning

confidence: 99%

Seminal fluid and reproduction: much more than previously thought

Bromfield

2014

J Assist Reprod Genet

123

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The influence of seminal plasma on the cytokine and immune uterine environment is well characterised in mice and humans, while the effects of disruption to uterine seminal plasma exposure on pregnancy and offspring health is becoming more clearly understood. The cellular and molecular environment of the uterus during the pre-and peri-implantation period of early pregnancy is critical for implantation success and optimal foetal and placental development. Perturbations to this environment not only have consequences for the success of pregnancy and neonatal health and viability, but can also drive adverse health outcomes in the offspring after birth, particularly the development of metabolic disorders such as obesity, hypertension and insulin resistance. It is now reported that an absence of seminal plasma at conception in mice promotes increased fat accumulation, altered metabolism and hypertension in offspring. The evidence reviewed here demonstrates that seminal plasma is not simply a transport medium for sperm, but acts also as a key regulator of the female tract environment providing optimal support for the developing embryo and benefiting future health of offspring.

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“…Previous studies of the impact of non-procreative intercourse on fertility have 1) examined intercourse during assisted reproductive technology and 2) largely focused on intercourse around the time of oocyte retrieval. Marconi et al found that couples who were undergoing gamete intrafallopian tube transfer were more likely to conceive if they had intercourse around the time of hCG administration (20). They did not examine the impact of peri-implantation intercourse on outcomes.…”

Section: Discussionmentioning

confidence: 99%

Peri-implantation intercourse lowers fecundability

Steiner

Pritchard

Young

et al. 2014

Fertility and Sterility

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Objective To determine the impact of sexual intercourse around the time of implantation on the probability of achieving a pregnancy. Design Time-to-pregnancy cohort using day-specific probability of pregnancy modeling to account for intercourse during the fertile window. Setting Community cohort. Patient(s) Women trying to conceive naturally, ages 30-44 without known infertility. Intervention(s) None. Main Outcome Measure(s) Positive pregnancy test Result(s) A total of 564 women provided 1,332 complete cycles for analysis. Intercourse frequency during the fertile window and during the peri-implantation window was significantly correlated. Cycles in which couples had 2 or more days with intercourse during the implantation window were significantly less likely to result in a positive pregnancy test compared to cycles in which couples didn’t have intercourse in this window, after adjusting for age, race, history of regular menstrual cycles, previous pregnancy, and body mass index (Fecundability Ratio=0.62, 95% Confidence Interval: 0.42-0.91). Conclusions Intercourse during the peri-implantation window may be detrimental to natural fertility. Methods that allow couples to time intercourse to the fertile window may decrease time to pregnancy by not only increasing the probability of fertilization but also decreasing the probability of failed implantation.

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Does sexual intercourse improve pregnancy rates in gamete intrafallopian transfer?

Cited by 33 publications

References 4 publications

A role for seminal plasma in modulating pregnancy outcomes in domestic species

A role for seminal plasma in modulating pregnancy outcomes in domestic species

Seminal fluid and reproduction: much more than previously thought

Peri-implantation intercourse lowers fecundability

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