Does Sericin, as a Novel Pleurodesis Agent, Have Higher Effectiveness Compared to Talcum Powder, Doxycycline, and Silver Nitrate Pleurodesis?

Does sericin pleurodesis increase the basic fibroblastic growth factor and high-sensitive c-reactive protein levels in rat plasma?

“…Compared to the other agents, sericin displayed significantly greater protective characteristics on lung parenchyma and a lower potential for inflammation than the other agents [4]. Additionally, side effects concerning the kidneys and the heart were significantly lower in the sericin group than in the other groups, which led the authors to conclude that the sericin powder is a better-tolerated, more cost-effective agent, associated with fewer side effects and offering superior protection of the lung parenchyma, offering more effective pleurodesis [4].…”

“…It was critically important to determine the appropriate dose of administration of the agents used in this study. The studies previously conducted by Yazicioglu et al used 30 mg sericin in rats and obtained successful results, and so we used the same dose of sericin in the present study [3,4]. The administrated dose of talcum powder in adults varied between 4 and 5 grams in previous studies, and so a dose of 17 mg was estimated to be appropriate for rats with a mean weight of 250 ± 30 g [9][10][11].…”

“…Sericin is a natural, macromolecular, gum-like protein that holds fibroin polymers together, and is a by-product of the textile sector [1]. Previous studies have shown the pleurodesis success of sericin powder [3,4]. Yazicioglu et al in an experimental study involving rats, concluded that the intrapleural administration of sericin increased fibroblastic activity and fibrosis in the visceral pleura, with no significant adverse effects on lung parenchyma [3].…”

“…Furthermore, the rats in the sericin pleurodesis group had lower inflammatory reactions, than the control group [3]. In another study involving rats, Yazicioglu et al compared sericin pleurodesis with talcum powder, doxycycline, and silver nitrate pleurodesis, and found that sericin pleurodesis was found to be better tolerated, the success of sericin pleurodesis was demonstrated, and the highest level of dense collagen fibers was noted in the sericin group [4]. Compared to the other agents, sericin displayed significantly greater protective characteristics on lung parenchyma and a lower potential for inflammation than the other agents [4].…”

“…In another study involving rats, Yazicioglu et al compared sericin pleurodesis with talcum powder, doxycycline, and silver nitrate pleurodesis, and found that sericin pleurodesis was found to be better tolerated, the success of sericin pleurodesis was demonstrated, and the highest level of dense collagen fibers was noted in the sericin group [4]. Compared to the other agents, sericin displayed significantly greater protective characteristics on lung parenchyma and a lower potential for inflammation than the other agents [4]. Additionally, side effects concerning the kidneys and the heart were significantly lower in the sericin group than in the other groups, which led the authors to conclude that the sericin powder is a better-tolerated, more cost-effective agent, associated with fewer side effects and offering superior protection of the lung parenchyma, offering more effective pleurodesis [4].…”