Does salpingectomy have a deleterious impact on ovarian response in in vitro fertilization cycles?

Yoon, Sang Hee; Lee, Ji Young; Kim, Soo Nyung; Chung, Hye Won; Park, So Yun; Lee, Chulmin

doi:10.1016/j.fertnstert.2016.05.030

Cited by 17 publications

(12 citation statements)

References 41 publications

(83 reference statements)

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“…Some recently published studies demonstrated that the clinical pregnancy rate for women undergoing IVF after salpingectomy was comparable to that for women with no previous salpingectomy [8,9,16,18]. We investigated whether salpingectomy affected the ovarian reserve, ovarian response and pregnancy outcomes for infertile women of different ages undergoing IVF.…”

Section: Introductionmentioning

confidence: 99%

Salpingectomy may decrease antral follicle count but not live birth rate for IVF-ET patients aged 35–39 years: a retrospective study

et al. 2020

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Purpose: Problems with fallopian tubes are one of the main reasons for women to undergo in vitro fertilizationembryo transfer (IVF-ET). A large proportion of women with ectopic pregnancy, fallopian tube obstruction and hydrosalpinx have had one or both fallopian tubes removed by salpingectomy. With increasing age, ovarian reserve deteriorates, the numbers of retrieved oocytes, available embryos and high-quality embryos are reduced, and the live birth rate for women treated with IVF treatment is affected. Thus, it is important to understand how salpingectomy affects live birth rates for IVF patients of different ages. This study analyzed how patients' age and salpingectomy influenced ovarian reserve, ovarian response and pregnancy outcomes for infertile women undergoing IVF-ET. Methods: A total of 1922 patients that underwent IVF-ET treatment from January 1, 2012, to December 31, 2018, were included in this retrospective study. The patients were divided into two groups according to whether or not they had a previous history of salpingectomy. The salpingectomy (group A, 534 patients) and control groups (group B, 1388 patients) were then further divided into two subgroups according to patient age (age<35 years, and age 35-39 years). Ovarian reserve, ovarian response, and IVF outcomes were investigated for each subgroup. Logistic regression model was used to estimate the relationship between clinical pregnancy and live births and patients' baseline characteristics. Results: In the salpingectomy group, antral follicle counts (AFC) were significantly lower for the subgroup aged 35 to 39 years compared with the control group. But this difference did not appear in women younger than 35 years. In addition, there were no significant differences in levels of basal follicle stimulation hormone (FSH), basal luteinizing hormone (LH), basal estradiol (E 2), total gonadotropins (Gn) dose, duration of Gn, numbers of retrieved oocytes, fertilization rates, numbers of available embryos, live birth rates, clinical pregnancy rates, miscarriage rates, ectopic pregnancy rates, or multiple pregnancy rates between the salpingectomy group and the control group (P > 0.05). Age is a risk factor for the clinical pregnancy and live birth. Conclusion: Salpingectomy may decrease antral follicle count but not live birth rate for IVF-ET patients aged 35-39 years. The increased female age was negative related with clinical pregnancy and live birth.

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Section: Introductionmentioning

confidence: 99%

Salpingectomy may decrease antral follicle count but not live birth rate for IVF-ET patients aged 35–39 years: a retrospective study

et al. 2020

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“…In the current investigation, the evaluated AMH was not follicular-fluid AMH and different kits were used to evaluate AMH. According to the meta-analyses conducted by Qin et al (37) and Yoon et al (38), further studies are required for confirming these findings.…”

Section: Discussionmentioning

confidence: 95%

A Comparison of Fertility Rates in Women Undergoing IVF with a Tubal Factor with Surgery, Tubal Factor Infertility Without Surgery, and Unexplained Infertility

Rezaei

Taghdisi

2020

J Obstet Gynecol Cancer Res

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“…Few studies have used this evaluation criterion [10][11][12][13]. Sonographic data were not used in the latest meta-analyses [8,14], and this limitation has been highlighted. This was a case-control study comparing the ovarian response within one patient (self-control study) and avoiding confounding factors that might exist between cases and controls (environmental impact, age, genetic, BMI, toxins, etc.…”

Section: Discussionmentioning

confidence: 99%

“…and its indication (EP, hydrosalpinx, endometriosis, and sterilisation, etc. ), including Yoon's meta-analysis (patients treated by salpingectomy for EP of hydrosalpinx) and studies by Fan, Noventa and Kotlyar (salpingectomy for any indication, comparing uni-or bilateral surgery to a control population or self-control study) [8,9,14,15]. Most of the studies evaluated small samples, with multiple evaluation criteria (mature follicle, retrieved oocytes, obtained embryos, pregnancy rates, and ovarian reserve parameters).…”

Section: Discussionmentioning

confidence: 99%

Impact of salpingectomy for ectopic pregnancy on the ovarian response during IVF stimulation

Gay

Perrin

Courbière

et al. 2019

Journal of Gynecology Obstetrics and Human Reproduction

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Introduction: Ovarian reserve is a major prognosic factor for Medical Assisted Procreation. Tubal surgery, realised close to mesosalpinx and ovarian vascularization, could impare ovarian function. However, salpingectomy is currently used to treat ectopic pregnancies or hydrosalpinx before IVF attempt. Disponible studies on this subject are unclear. The aim of this study is to evaluate the impact of salpingectomy for ectopic pregnancy on the ovarian response during IVF attempt. Material and methods: It was a single center comparative study. Included patients were the one receiving oocyte puncture for IVF attempt, with a history of unilateral tubal surgery: salpingectomy for ectopic pregnancy. We conducted a case-control study, comparing the sonographic parameters of the surgery ovary (case) to those of the safe ovary (control) during the first IVF attempt after salpingectomy. The ovarian sonographic response was evaluated according to the follicular antral count on day 3 and the sonographic follicular count on trigger day. Results: 55 patients were included. There was no significant difference in the number of recruited follicles on the operated side versus control side (p = 0.85 for >14 mm follicles, p = 0,46 for 10 to 14 mm, p = 0,52 for total amount of recruited follicles). There was no significant difference for the follicular antral count neither (p = 0.79). Discussion: In our population, there was no significant difference in the sonographic ovarian response to IVF stimulation between the ovary on the operated side and the control ovary among patients treated by unilateral salpingectomy for ectopic pregnancy.

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Does salpingectomy have a deleterious impact on ovarian response in in vitro fertilization cycles?

Abstract: Salpingectomy in infertile patients does not have any negative effect on their subsequent fertility treatment, but further studies should be performed before this result can be considered definitive.

Cited by 17 publications

References 41 publications

Salpingectomy may decrease antral follicle count but not live birth rate for IVF-ET patients aged 35–39 years: a retrospective study

Salpingectomy may decrease antral follicle count but not live birth rate for IVF-ET patients aged 35–39 years: a retrospective study

A Comparison of Fertility Rates in Women Undergoing IVF with a Tubal Factor with Surgery, Tubal Factor Infertility Without Surgery, and Unexplained Infertility

Impact of salpingectomy for ectopic pregnancy on the ovarian response during IVF stimulation

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