Does REM sleep behavior disorder change in the progression of Parkinson’s disease?

Figorilli, Michela; Marqués, Ana; Vidal, Tiphaine; Delaby, Laure; Meloni, Mario; Pereira, Bruno; Lambert, Céline; Puligheddu, Monica; Durif, Franck; Fantini, María Livia

doi:10.1016/j.sleep.2019.12.013

Cited by 32 publications

(23 citation statements)

References 22 publications

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“…This is concordant with the study by Gerbin, Viner, and Louis (2012), who also found ET patients to have intermediate values (between PD patients and controls) in sleep‐scale scores. The RSWA index, which has been found to correlate with markers of disease progression in PD patients (Figorilli et al, 2020), did not differ significantly between groups, again suggesting that ET‐RBD patients could present with a degree of neurodegeneration similar to that of alpha‐synucleinopathies.…”

Section: Discussionmentioning

confidence: 85%

REM sleep behaviour disorder in essential tremor: A polysomnographic study

Bugalho

Salavisa

Borbinha

et al. 2020

Journal of Sleep Research

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Our objectives were to assess the prevalence of REM sleep behaviour disorder in patients with Essential Tremor, using video-polysomnography and to compare REM sleep behaviour disorder features in essential tremor with those of patients with alpha-synucleinopathies. Forty-nine patients with essential tremor were screened with the REM Sleep Behaviour Disorder Screening Questionnaire. Patients scoring positive and those with spontaneous complaints of REM sleep behaviour disorder (n = 6) underwent video-polysomnography. The clinical features of essential tremor were compared between patients with and without REM sleep behaviour disorder.

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Section: Discussionmentioning

confidence: 85%

REM sleep behaviour disorder in essential tremor: A polysomnographic study

Bugalho

Salavisa

Borbinha

et al. 2020

Journal of Sleep Research

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“…Furthermore, RBD status, especially assessed by questionnaire, can fluctuate during the evolution of PD, 9,31,32 whereas PSG‐assessed RBD has been found to persist over time 6‐8 . This can be due to the lower accuracy of the questionnaire compared to PSG, but also to spontaneous changes in the clinical, but not PSG, manifestations of the parasomnia 8 . To take into account this phenomenon, a set of analyses was performed in PD patients according to the mTD RBD model (ie, considering subjects as pRBD+ from the first month onward that the patient had an RBDSQ score ≥ 6).…”

Section: Discussionmentioning

confidence: 99%

“…Along with BL pRBD, we examined a TD and a modified TD (mTD) pRBD in our analysis. RBD status assessed by questionnaire can fluctuate during the evolution of PD, 7,31,32 whereas vPSG‐assessed RBD tends to persist over time 6–8 . This can be due to the lower accuracy of questionnaires compared to PSG, but also to spontaneous changes in clinical, but not PSG, manifestations of the parasomnia.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, no information from bed partner or caretaker was available, potentially leading to an underestimation of the prevalence of both RBD and ICBs. Furthermore, RBD status, especially assessed by questionnaire, can fluctuate during the evolution of PD, 9,31,32 whereas PSG‐assessed RBD has been found to persist over time 6‐8 . This can be due to the lower accuracy of the questionnaire compared to PSG, but also to spontaneous changes in the clinical, but not PSG, manifestations of the parasomnia 8 .…”

Section: Discussionmentioning

confidence: 99%

“…About 33 to 60% of PD patients have rapid eye movement sleep behavior disorder (RBD), 4 a parasomnia characterized by elaborate and violent motor behaviors during sleep, often associated with vivid aggressive dreams 5 . RBD is a premotor, or prodromal, symptom of PD, has a prevalence estimated up to 25% in de novo parkinsonian patients, 6 and tends to increase over the initial years of the disease 6–9 . PD comorbid with RBD predicts a more severe course of the disease, with earlier axial symptoms and greater cognitive decline 10,11 …”

Section: Introductionmentioning

confidence: 99%

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Is Rapid Eye Movement Sleep Behavior Disorder a Risk Factor for Impulse Control Disorder in Parkinson Disease?

Fantini

Fedler

Pereira³

et al. 2020

Annals of Neurology

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Objective: To assess the association between rapid eye movement sleep behavior disorder (RBD) and other determinants and incident impulse control disorder behaviors (ICBs) in patients with early Parkinson disease (PD) using longitudinal data from the Parkinson's Progression Markers Initiative. Methods: Four hundred one newly diagnosed PD patients were prospectively evaluated at baseline (BL), month 6, and annually for 5 years. Probable RBD (pRBD) was assessed with the RBD Screening Questionnaire (RBDSQ) and dichotomized using a cutoff value of ≥6. The association of BL and time-dependent (TD) pRBD and other covariates with the development of ICB symptoms was evaluated using Cox proportional hazards regression and general estimating equation logistic regression. Models considered adjustment for age, sex, Movement Disorders Society Unified Parkinson's Disease Rating Scale part III, Geriatric Depression Scale (GDS-15), RBD medication use, total levodopa equivalent daily dose, and dopamine agonist (DA) and antidepressant medication use. Results: Both BL pRBD and TD pRBD were not associated with an increased risk for incident ICB symptoms after adjustment for covariates (adjusted hazard ratio [HR] = 1.17, p = 0.458 and HR = 1.27, p = 0.257, respectively). In a modified TD pRBD model (ie, considering subjects as pRBD onward from the first time point with RBDSQ score ≥ 6), the risk for incident ICB symptoms was higher in pRBD in unadjusted (HR = 1.48, p = 0.038) but not adjusted (HR = 1.29, p = 0.203) models. TD DA use (HR = 1.64, p = 0.039), TD GDS-15 score (HR = 1.12, p < 0.001), and male sex (year 3: HR = 2.10, p = 0.009; year 4: HR = 3.04, p = 0.006; year 5: HR = 4.40, p = 0.007) were associated with increased ICB symptom risk. Interpretation: pRBD is not clearly associated with ICB symptom development in early PD, in contrast to DA use, depression, and male sex.

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Incidence and Progression of Rapid Eye Movement Behavior Disorder in Early Parkinson's Disease

Zimansky

Muntean

Leha

et al. 2021

Movement Disord Clin Pract

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BackgroundBackground: Rapid eye movement (REM) sleep behavior disorder (RBD) is associated with neurodegenerative diseases; however, few longitudinal studies assess the individual evolution of RBD and REM sleep without atonia (RWA) in Parkinson's disease (PD). Objectives Objectives: We aimed to evaluate RBD and RWA changes over time as well as potentially influential factors. Methods Methods: RBD and RWA were analyzed using video-supported polysomnography (vPSG) in initially de novo PD patients at baseline and every 2 years for a total of 6 years. The influence of time, age, sex, levodopa equivalent daily dose (LEDD), unified Parkinson's disease rating scale (UPDRS) sum scores, benzodiazepine intake, Mini-Mental State Examination (MMSE) total scores, and dyskinesia on RWA were investigated using mixed-effect models to account for intra-individual correlations. Results Results: After 6 years, vPSG data were available from 98 of the initial 159 de novo PD patients. RBD prevalence increased from 25% at baseline to 52%. Of the 31 PD patients with RBD and valid vPSGs at all time-points, RWA increased from an average of 19% at baseline to 41% at 6-year follow-up modeled to grow by 29.7% every 2 years (P < 0.001). Time was an independent factor (P < 0.001) for RWA increase. Age was an independent factor influencing RWA increase (P = 0.04). Sex, LEDD, UPDRS sum scores, benzodiazepines, MMSE total scores, and dyskinesia did not have any significant influence. Conclusions Conclusions: RBD and RWA increased significantly over time in PD; time and age were independent factors in a prospective cohort. RBD and RWA can be considered PD progression markers.Rapid eye movement (REM) sleep behavior disorder (RBD), a parasomnia characterized by dream-enacting motor behaviors and/or vocalizations, 1,2 is a precursor to neurodegenerative diseases associated with the misprocessing of α-synuclein. 3,4 A recent meta-analysis calculated an annual conversion rate of 6.3% of patients with isolated RBD (iRBD) into any neurodegenerative disease. 5 Data from functional imaging studies 6 highlighted the role of RBD as a premotor manifestation of Parkinson's disease (PD) and as a diagnostic marker for α-synuclein aggregation disorders. A recent study using the REM sleep behavior screening questionnaire tried to identify "probable RBD" and an association was found between motor and cognitive decline in probable RBD patients. 7 In manifest PD, a recent meta-analysis (n = 2462) calculated an overall mean prevalence of RBD of 23.6% in newly diagnosed PD, with a wide range (4.3%-69.4%) most likely because of the lack of polysomnographic validation in all but 1 of the 8 studies. 8 This 1 study comprised the baseline report of our de novo Parkinson (DeNoPa) sleep cohort and identified polysomnographically validated RBD in 25% of newly diagnosed, drug-naïve PD patients. 9 RBD prevalence increased to 43% at 2-year follow-up. 10 In a large cohort of PD patients at various

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Does REM sleep behavior disorder change in the progression of Parkinson’s disease?

Cited by 32 publications

References 22 publications

REM sleep behaviour disorder in essential tremor: A polysomnographic study

REM sleep behaviour disorder in essential tremor: A polysomnographic study

Is Rapid Eye Movement Sleep Behavior Disorder a Risk Factor for Impulse Control Disorder in Parkinson Disease?

Incidence and Progression of Rapid Eye Movement Behavior Disorder in Early Parkinson's Disease

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