Does Reflux Have a Causative Role in Laryngomalacia?

Manaligod, José R.

doi:10.4172/2161-119x.1000142

Cited by 3 publications

(1 citation statement)

References 38 publications

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“…The pathogenesis of laryngomalacia remains unclear. However, its pathogenesis may involve structural abnormalities to the laryngeal cartilage, neuromuscular dysfunction, and gastroesophageal re ux that occur during the onset of the condition in children [3][4][5]. In most children, laryngomalacia presents as mild to moderate condition and is mainly diagnosed 4-5 months after birth, and most symptoms disappear within 12 months [6].…”

Section: Introductionmentioning

confidence: 99%

Preterm birth, low birth weight, and medical comorbidities are risk factors for severe laryngomalacia in children

Ding

et al. 2023

Preprint

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Objective To analyze the clinical characteristics and the risk factors associated with severe laryngomalacia in children.Methods In this study, the clinical data of children (0–18 years), including gender, age at presentation, preterm delivery, low birth weight, delivery mode, feeding mode, fetal delivery, medical comorbidities, maternal gestational age at presentation, and calcium supplementation during pregnancy, diagnosed with laryngomalacia between January 2013 and January 2023 were retrospectively analyzed. The children were divided into mild-moderate and severe groups. Several risk factors were compared and analyzed between the two groups. The statistically significant risk factors were included in the logistic regression analysis.Results A total of 224 children with severe laryngomalacia were enrolled in this study. The ratio of male to female patients was 1.55: 1. All patients had severe laryngomalacia manifested by inspiratory laryngeal stridor. The average age of patients at symptom presentation was 2.7 (1.5–5.2) months. There were significant differences between the two groups in the age at presentation, premature delivery, low birth weight, medical comorbidities, and calcium supplementation during pregnancy (P < 0.05). Multivariate logistic regression analysis showed that premature delivery (OR = 3.177, 95% CI:2.329–4.334), low birth weight (OR = 3.188, 95%CI:2.325–4.370), and medical comorbidities (OR = 1.434, 95% CI:1.076–1.909) were independent risk factors for severe laryngomalacia (P < 0.05).Conclusion Children with severe laryngomalacia exhibited persistent stridor at an earlier age at presentation. Premature delivery, low birth weight, and medical comorbidities were potential risk factors for severe laryngomalacia in children.

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Section: Introductionmentioning

confidence: 99%

Preterm birth, low birth weight, and medical comorbidities are risk factors for severe laryngomalacia in children

Ding

et al. 2023

Preprint

View full text Add to dashboard Cite

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Common causes of congenital stridor in infants

Clark

Kugler

Carr

2018

Jaapa

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Stridor is a high-pitched respiratory sound that signals upper airway obstruction. It can be encountered by clinicians in a variety of clinical settings and requires a team-based, interdisciplinary approach. Early recognition is crucial, as the differential diagnosis can be broad, and causes range from benign to life-threatening. This article reviews the most commonly encountered causes of chronic congenital stridor in infants, focusing on the diagnostic approach, pathophysiology, clinical presentation, and management strategies.

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Preterm Birth, Low Birth Weight, and Medical Comorbidities Are Risk Factors for Severe Laryngomalacia in Children

Chen,

Yang,

Tang

et al. 2024

Ear Nose Throat J

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Objective: To analyze the clinical characteristics and the risk factors associated with severe laryngomalacia in children. Methods: In this study, the clinical data of children (0-18 years), including gender, age at presentation, preterm delivery, low birth weight, delivery mode, feeding mode, fetal delivery, medical comorbidities, maternal gestational age at presentation, and calcium supplementation during pregnancy, diagnosed with laryngomalacia between January 2013 and January 2023 were retrospectively analyzed. The children were divided into mild-moderate and severe groups. Several risk factors were compared and analyzed between the 2 groups. The statistically significant risk factors were included in the logistic regression analysis. Results: A total of 224 children with severe laryngomalacia were enrolled in this study. The ratio of male to female patients was 1.55:1. All patients had severe laryngomalacia manifested by inspiratory laryngeal stridor. The average age of patients at symptom presentation was 2.7 (1.5-5.2) months. There were significant differences between the 2 groups in the age at presentation, premature delivery, low birth weight, medical comorbidities, and calcium supplementation during pregnancy ( P < .05). Multivariate logistic regression analysis showed that premature delivery [odds ratio (OR) = 3.177, 95% confidence interval (CI): 2.329-4.334], low birth weight (OR = 3.188, 95% CI: 2.325-4.370), and medical comorbidities (OR = 1.434, 95% CI: 1.076-1.909) were independent risk factors for severe laryngomalacia ( P < .05). Conclusion: Children with severe laryngomalacia exhibited persistent stridor at an earlier age at presentation. Premature delivery, low birth weight, and medical comorbidities were potential risk factors for severe laryngomalacia in children.

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Does Reflux Have a Causative Role in Laryngomalacia?

Cited by 3 publications

References 38 publications

Preterm birth, low birth weight, and medical comorbidities are risk factors for severe laryngomalacia in children

Preterm birth, low birth weight, and medical comorbidities are risk factors for severe laryngomalacia in children

Common causes of congenital stridor in infants

Preterm Birth, Low Birth Weight, and Medical Comorbidities Are Risk Factors for Severe Laryngomalacia in Children

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