Does reactivation trigger episodic memory change? A meta-analysis

Scully, Iiona D.; Napper, Lucy E.; Hupbach, Almut

doi:10.1016/j.nlm.2016.12.012

Cited by 80 publications

(73 citation statements)

References 69 publications

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“…However, functional connectivity with the hippocampus revealed earlier posterior medial network involvement when adopting an OB perspective, coupled with greater engagement of an MTL network when adopting an OE perspective during elaboration. The current findings contribute to research on how visual perspective shapes memories during retrieval (Marcotti and St Jacques 2018; Sekiguchi and Nonaka 2014; St Jacques and others 2017), in line with theories of memory that propose retrieval is an active process that can reshape memories (e.g., Moscovitch and others 2016; Schacter and others 2011; Scully and others 2017). Better understanding of the neural mechanisms that support the fundamental capacity to understand ourselves from multiple perspectives when remembering the past could also contribute to research on how we flexibly understand the perspective of others (Carrington and Bailey 2009).…”

Section: Resultssupporting

confidence: 82%

Construction and Elaboration of Autobiographical Memories from Multiple Visual Perspectives

Iriye

Jacques

2018

Preprint

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Visual perspective, recalling events from one’s own eyes or from an observer-like viewpoint, is a fundamental aspect of autobiographical memory (AM). Yet, how visual perspective influences the functional mechanisms supporting retrieval is unclear. Here, we used a multivariate neuroimaging analysis to characterize the spatiotemporal dynamics supporting AM retrieval from multiple visual perspectives. Both own eyes and observer perspectives engaged an AM retrieval network (i.e., hippocampus, anterior and posterior midline, lateral frontal and posterior cortices) that peaked during later retrieval periods but was recruited less strongly for observer perspectives. Functional connectivity analyses with an anterior hippocampal seed revealed that visual perspective also altered interactions among neural regions and their timing during retrieval. There was stronger hippocampal connectivity with a posterior medial network during the initial construction of AMs from observer perspectives and stronger connectivity with a medial temporal lobe network during later retrieval periods from own eyes perspectives, suggesting that visual perspective directs how neocortical systems guide retrieval. Our findings demonstrate that visual perspective influences AM retrieval by altering hippocampal-neocortical interactions and subsequently the strength of neural recruitment in the AM retrieval network during later retrieval periods, thereby supporting the central role of visual perspective in shaping the personal past.

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Section: Resultssupporting

confidence: 82%

Construction and Elaboration of Autobiographical Memories from Multiple Visual Perspectives

Iriye

Jacques

2018

Preprint

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“…In procedural memories, for example, when a finger-tapping sequence memory was reactivated and followed by a new sequence, the accuracy of the initial memory diminished [13]. Declarative memories are also vulnerable to new or conflicting information that follows reactivation, affecting the amount of information retrieved from the original memory or enhancing intrusions of the new material into it [32]. For example, learning of a new list of objects following the reactivation of a previously learned list, caused items from the second learning to infiltrate the memory of the first list [33].…”

Section: Reconsolidation Updates Memoriesmentioning

confidence: 99%

An Update on Memory Reconsolidation Updating

Lee

Nader

Schiller

2017

Trends in Cognitive Sciences

417

368

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The reactivation of a synaptically stored memory in the brain can make the memory transiently labile. During the time it takes for the memory to re-stabilize (reconsolidate), the memory can either be reduced by an amnesic agent or enhanced by memory enhancers. The change in memory expression is related to changes in the brain correlates of long-term memory. Many have suggested that such retrieval-induced plasticity is ideally placed to enable memories to be updated with new information. This hypothesis has been tested experimentally, with a translational perspective, by attempts to update maladaptive memories in order to reduce their problematic impact. Here, we review the progress on reconsolidation-update studies, highlighting their translational exploitation and addressing recent challenges to the reconsolidation field.

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“…Das, Freeman, & Kamboj, 2013) or, in the case of human studies, primarily on experimentally-generated memories, examining a single reconsolidation interference strategy (e.g. Kredlow et al, 2016; or memory system (Scully, Napper, & Hupbach, 2017). Such analyses are critical for furthering our understanding of the modulators of this fundamental memory process.…”

Section: The Current Reviewmentioning

confidence: 99%

Modulation of naturalistic maladaptive memories using behavioural and pharmacological reconsolidation-interfering strategies: A systematic review and meta-analysis of clinical and 'sub-clinical' studies

Walsh

Das

Saladin

et al. 2018

Preprint

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Consolidated memories can undergo enduring modification through retrieval-dependent treatments that modulate reconsolidation. This has been suggested to represent a potentially transformative clinical strategy for weakening or overwriting the maladaptive memories that underlie substance use and anxiety/trauma-related disorders. However, the ability to modulate naturalistic maladaptive memories may be limited by 'boundary conditions' imposed on reconsolidation by the nature of these memories. As such, the true potential of 'reconsolidation therapy' is currently unknown. Here, we report a meta-analyses of behavioural and pharmacological studies examining retrieval-dependent modulation of reward and threat memories in (sub)clinical substance use and anxiety/trauma respectively.Of 4936 publications assessed for eligibility, 7 studies of substance use, and 9 of anxiety (phobia) and trauma-related symptoms were included in the meta-analyses. Overall, the findings were in the predicted direction, with the majority of effect sizes favouring the 'Retrieval + Treatment' condition. However, the magnitude of effects depended upon the nature of the treatment type, with pharmacological interventions (relative to behavioural strategies) showing a clearer beneficial effect in studies of phobia/trauma and post-retrieval behavioural strategies, a (significantly) larger effect in substance use studies. However, high levels of heterogeneity and small sample sizes limit the strength of conclusions that can be drawn at this stage of inquiry. We hope this review will provide an impetus to address these issues in future research.

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Does reactivation trigger episodic memory change? A meta-analysis

Cited by 80 publications

References 69 publications

Construction and Elaboration of Autobiographical Memories from Multiple Visual Perspectives

Construction and Elaboration of Autobiographical Memories from Multiple Visual Perspectives

An Update on Memory Reconsolidation Updating

Modulation of naturalistic maladaptive memories using behavioural and pharmacological reconsolidation-interfering strategies: A systematic review and meta-analysis of clinical and 'sub-clinical' studies

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