An Update on Memory Reconsolidation Updating

Lee, Jonathan; Nader, Karim; Schiller, Daniela

doi:10.1016/j.tics.2017.04.006

Cited by 437 publications

(408 citation statements)

References 139 publications

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“…In a familiar context, the organism can bring its past experience in the context to bear on upcoming decisions and actions. Violations of predictions formed from past experiences in the context could lead to the formation of an entirely new context representation, or alternatively, the new information could be accommodated within an already existing context map—these phenomena are currently being studied under the rubric of ‘memory reconsolidation’ 14 , ‘memory updating’ 15–18 , and ‘integrative encoding’ 19 . In other words, hippocampal context representations can stimulate exploratory behavior, inform decisions from past experience, or rapidly update our understanding of the current state of the world.…”

Section: What Is the Global Function Of The Hippocampus And How Doesmentioning

confidence: 99%

Viewpoints: how the hippocampus contributes to memory, navigation and cognition

et al. 2017

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The hippocampus serves a critical function in memory, navigation, and cognition. Nature Neuroscience asked John Lisman to lead a group of researchers in a dialog on shared and distinct viewpoints on the hippocampus. There has been a long history of studying the hippocampus, but recent work has made it possible to study the cellular and network basis of defined operations—operations that include cognitive processes that have been otherwise difficult to study (see Box 1 for useful terminology). These operations deal with the context-dependent representation of complex memories, the role of mental exploration based on imagined rather than real movements, and the use of recalled information for navigation and decision-making. The progress that has been made in understanding the hippocampus has motivated the study of other brain regions that provide hippocampal input or receive hippocampal output; the hippocampus is thus serving as a nucleating point for the larger goal of understanding the neural codes that allow inter-regional communication and more generally, understanding how memory-guided behavior is achieved by large scale integration of brain regions. In generating a discussion among experts in the study of the cognitive processes of the hippocampus, the editors and I have posed questions that probe important principles of hippocampal function. We hope that the resulting discussion will make clear to readers the progress that has been made, while also identifying issues where consensus has not yet been achieved and that should be pursued in future research. – John Lisman

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Section: What Is the Global Function Of The Hippocampus And How Doesmentioning

confidence: 99%

Viewpoints: how the hippocampus contributes to memory, navigation and cognition

et al. 2017

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“…Following exposure to a stimulus that reactivates this circuit, the memory trace becomes labile again, allowing it to be manipulated pharmacologically. Reconsolidation has been proposed as a potential strategy to erase unwanted memories in conditions associated with adverse events, such as in post-traumatic stress disorder (PTSD) [75,76]. Remarkably, reconsolidation also occurs in the spinal cord [74,77,78], raising the potential for therapeutic strategies based on this approach.…”

Section: Targeting Translation For Therapeutic Development Of Next-gementioning

confidence: 99%

Translational Control Mechanisms in Persistent Pain

Khoutorsky

Price

2018

Trends in Neurosciences

100

114

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Persistent pain, which is poorly treated and estimated to afflict one third of the world’s population, is largely mediated by the sensitization of nociceptive neurons. This sensitization involves de novo gene expression to support biochemical and structural changes required to maintain amplified pain signaling that frequently persists even after injury to tissue resolves. While transcription-dependent changes in gene expression are important, recent work demonstrates that activity-dependent regulation of mRNA translation is key to controlling the cellular proteome and the development and maintenance of persistent pain. In this review, we highlight recent advances in translational regulation of gene expression in nociceptive circuits, with a focus on key signaling pathways and mRNA targets that may be tractable for the creation of next-generation pain therapeutics.

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“…In the second phase, mice underwent place counterconditioning with water-flood, 45 min after memory retrieval by a brief re-exposure to the alcohol-paired compartment (Retrieval group) or handling (control, No Retrieval group). The 45-min interval was chosen for the counterconditioning to be held within the 'reconsolidation window' (Nader and Hardt, 2009;Xue et al, 2012;Lee et al, 2017). The subsequent Place preference test 2 confirmed that aversive counterconditioning led to the loss of place preference in both groups ( Figure 1B).…”

Section: Resultsmentioning

confidence: 76%

“…Current concepts suggest that memories undergo de-stabilization upon their reactivation via memory retrieval, and then restabilize within a few hours in a process termed "reconsolidation" (Przybyslawski and Sara, 1997;Nader et al, 2000). While in a temporary active state (termed "reconsolidation window"), memories can be disrupted, updated, or strengthened (Nader and Hardt, 2009;Nader, 2015;Dunbar and Taylor, 2017b;Lee et al, 2017;Gisquet-Verrier and Riccio, 2018), providing a promising therapeutic approach for relapse prevention in addiction (Tronson and Taylor, 2013;Vousden and Milton, 2017;Exton-McGuinness and Milton, 2018). It is established that memory reconsolidation can be disrupted by pharmacological manipulations (Nader et al, 2000;Dunbar and Taylor, 2017b).…”

Section: Introductionmentioning

confidence: 99%

Disruption of relapse to alcohol seeking by aversive counterconditioning following memory retrieval

Goltseker

Handrus

Barak

2019

Preprint

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Relapse to alcohol abuse is often caused by exposure to potent alcohol-associated cues. Therefore, disruption of the cue-alcohol memory can prevent relapse. It is believed that memories destabilize and become prone for updating upon their reactivation through retrieval, and then re-stabilize within 6 h during a "reconsolidation" process. We recently showed that relapse to cocaine seeking could be prevented by counterconditioning the cocaine-cues with aversive outcomes following cocaine-memory retrieval, in a place conditioning paradigm. However, to better model addictionrelated behaviors, self-administration models are necessary. Here, we demonstrate that relapse to alcohol seeking can be prevented by aversive counterconditioning conducted during alcoholmemory reconsolidation, in conditioned place preference (CPP) and operant self-administration paradigms, in mice and rats, respectively. We found that the reinstatement of alcohol-CPP was abolished only when aversive counterconditioning with water-flooding was given shortly after alcohol-memory retrieval. Furthermore, rats trained to lever-press for alcohol showed decreased context-induced renewal of alcohol-seeking responding when the lever-pressing was counterconditioned with foot-shocks, shortly, but not 6 h, after memory retrieval. These results 0suggest that aversive counterconditioning can prevent relapse to alcohol seeking only when performed during alcohol-memory reconsolidation, presumably by updating, or replacing, the alcohol memory with aversive information. Also, we found that aversive counterconditioning preceded by alcohol-memory retrieval was characterized by upregulation of brain-derived neurotrophic factor (Bdnf) mRNA expression in the medial prefrontal cortex, suggesting that Bdnf plays a role in the memory updating process. Operant self-administration, Conditioned place preference, BDNFAlcohol place conditioning (days 2-9): Training started 24 h after the Baseline test with one session per day over 8 days, with the sliding door closed. On days 3, 5, 7, and 9, mice were administered with alcohol (1.8 g/kg; i.p.) and immediately confined to the paired compartment for 5 min. On the alternate days (days 2, 4, 6, and 8), mice were administered with saline and were confined to the unpaired compartment for the same duration as on the alcohol-conditioning day.Paired compartments were counterbalanced.Place preference test 1 (day 10): Place preference test was identical to the Baseline stage, and served to index alcohol-CPP (Cunningham et al., 2003). Preference was defined as an increase in the percent of time spent in the alcohol-paired compartment during the Place preference test 1 compared to the Baseline test. Mice that did not show CPP (minimum of 5% change) were excluded from the experiment (3 from Experiment 1; 4 from Experiment 2).Memory retrieval and aversive counterconditioning (days 11-14). Prior to this stage, mice were assigned to different experimental conditions, Retrieval and No Retrieval (matched for CPP scores and sex). Training began 2...

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An Update on Memory Reconsolidation Updating

Cited by 437 publications

References 139 publications

Viewpoints: how the hippocampus contributes to memory, navigation and cognition

Viewpoints: how the hippocampus contributes to memory, navigation and cognition

Translational Control Mechanisms in Persistent Pain

Disruption of relapse to alcohol seeking by aversive counterconditioning following memory retrieval

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