Does Pregnancy-associated Plasma Protein A have a Role in Allergic Rhinitis?

Güçlü, Ender; Coşkun, Abdurrahman; Tokmak, Abdurrahman; Duran, Sadik; Öztürk, Özcan; Akkan, Nermin; Egeli, Erol

doi:10.2500/ajr.2008.22.3179

Cited by 4 publications

(1 citation statement)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Conversely, PAPP-A was associated with increased mortality in type 1 diabetic patients with nephropathy but only in unadjusted analysis; after adjustment for traditional risk factors the prognostic value of PAPP-A was no longer signifi cant (14) . PAPP-A was signifi cantly elevated in allergic rhinitis (15) and in asthma and correlated with asthma severity (16) . In children there was no difference between obese and lean subjects but a correlation with other cardiovascular risk factors was found (17) .…”

Section: History Of Papp-a In Laboratory Medicinementioning

confidence: 99%

Pregnancy-associated plasma protein A: spotlight on kidney diseases

Kalousová

Tesař

Muravská

et al. 2012

Clinical Chemistry and Laboratory Medicine (CCLM)

View full text Add to dashboard Cite

Pregnancy-associated plasma protein A (PAPP-A) is a biomarker routinely used in screening for Down syndrome in the fi rst trimester of pregnancy. It is also present in very small amounts in men and non-pregnant women. PAPP-A is a key regulator of local insulin-like growth factor (IGF) bioavailability -IGFs are essential for normal body size during fetal development, but they are associated with aging and agerelated diseases. Measurement of circulating PAPP-A can provide valuable information not only in pregnant women (chromosomal anomalies and adverse pregnancy outcomes) but also in patients with coronary artery disease (contribution to diagnosis, prognostic value) and in patients with kidney diseases. PAPP-A is associated with renal function and proteinuria, is increased mainly in dialysis patients and decreases after kidney transplantation. It is an independent mortality predictor of hemodialysis patients and indicator of adverse outcome of transplanted patients. PAPP-A levels can be infl uenced by various chemicals and drugs, among them mainly heparin. Various assays for PAPP-A exist and the type of assay used in a study should be considered. This article reviews the data summarizing basic information about PAPP-A with a particular focus on the signifi cance of PAPP-A in renal diseases.

show abstract