Pregnancy-associated plasma protein A: spotlight on kidney diseases

Kalousová, Marta; Tesař, Vladimı́r; Muravská, Alexandra; Zima, Tomáš

doi:10.1515/cclm-2011-0640

Cited by 10 publications

(11 citation statements)

References 57 publications

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“…Interestingly, FR, which reduced cystic disease in the murine model, also significantly reduced Pappa mRNA expression. PAPP-A has been shown to correlate with renal function, be present in higher levels in patients on dialysis, and serve as an independent predictor of mortality of patients on hemodialysis (49,50,51). PAPP-A is also a marker of inflammation in dialysis patients (85,86).…”

Section: Discussionmentioning

confidence: 99%

“…PAPP-A is also involved in pathogenesis of several disease and is a therapeutic target in diseases such as atherosclerosis and cancer, as well as age-related diseases (43)(44)(45)(46)(47)(48). Plasma PAPP-A has also been shown to correlate with renal function, been present at higher levels in patients on dialysis, and serve as an independent predictor of mortality of patients on hemodialysis (49)(50)(51). PAPP-A is ubiquitously expressed in several organs in humans (41,(52)(53)(54)(55)(56) and highly expressed in the human placenta (57).…”

Section: Papp-a Levels Increase With the Progression Of Cystic Diseasementioning

confidence: 99%

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Metalloproteinase PAPP-A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis

Kashyap¹,

Hein²,

Chini³

et al. 2020

JCI Insight

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Section: Discussionmentioning

confidence: 99%

Section: Papp-a Levels Increase With the Progression Of Cystic Diseasementioning

confidence: 99%

Metalloproteinase PAPP-A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis

Kashyap¹,

Hein²,

Chini³

et al. 2020

JCI Insight

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“…During pregnancy, high concentrations of PAPP-A are produced by trophoblasts and PAPP-A has been used in prenatal screening for genetic anomalies such as Down syndrome (7). Despite its name, PAPP-A is not specific to pregnancy; it is found in both males and non-pregnant females (8). Additionally, elevated PAPP-A levels have also been reported in patients with renal impairment, asthma and lung cancer (9)(10)(11).…”

Section: Fumar Cigarrillos Representa Para Los Hombres Un Aumento De mentioning

confidence: 99%

Cigarette Smoking Increases Pregnancy-associated Plasma Protein-A in Men

Coşkun¹,

Bulut²,

Serteser³

et al. 2015

West Indian Med J

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Objective: Elevation of pregnancy-associated plasma protein-A (PAPP-A), a pro-atherosclerotic molecule, has been shown to be an independent risk factor for acute coronary syndrome. Smoking is also an important risk factor for acute coronary syndrome (ACS). However, the molecular mechanism of this relationship is not clear. In the present study, we aimed to determine the association between smoking and serum PAPP-A levels in men and non-pregnant women. Method: The study population consisted of 112 smokers and 58 age-matched non-smoking healthy subjects as a control group. Blood samples were drawn from the antecubital vein of all subjects and serum PAPP-A levels were measured using an ELISA kit (ultrasensitive ELISA). Results: The serum PAPP-A level was significantly high in male smokers (smokers: 9.11 ng/mL (3.10 ng/mL, 18.55 ng/mL)); controls: 7.44 ng/mL (< 0.023 ng/mL, 16.54 ng/mL); p < 0.05)) but not in female smokers (smokers: 4.49 ng/mL (< 0.023 ng/mL, 11.92 ng/mL); controls: 5.95 ng/mL (< 0.023 ng/mL, 15.61 ng/mL); p > 0.05)). In male smokers, the correlations between serum PAPP-A levels and age, body mass index (BMI), duration of smoking (years), and number of cigarettes smoked per day were not statistically significant (p > 0.05). Conclusion: Serum PAPP-A levels are higher in male smokers, and this may indicate a higher risk for ACS among men.

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“…It is a predictor of cardiovascular events among patients with cardiac chest pain and is associated with patients´ prognosis [10, 11]. Several studies documented increased PAPP-A levels in patients with chronic kidney disease [12]. Data from different patient cohorts with end-stage renal disease patients treated with long-term hemodialysis demonstrate the association of serum PAPP-A levels with adverse outcome [13-17].…”

Section: Introductionmentioning

confidence: 99%

Pregnancy-Associated Plasma Protein A2 in Hemodialysis Patients: Significance for Prognosis

Kalousová

Dusilová-Sulková

Kubêna

et al. 2017

Kidney Blood Press Res

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Background: Pregnancy-associated plasma protein A (PAPP-A) is associated with adverse outcome of long-term hemodialysis patients (HD). The aim of the study was to test whether its homolog pregnancy-associated plasma protein A2 (PAPP-A2) can be detected in serum of HD patients and to define its significance. Methods: The studied group consisted of 102 long-term HD patients and 25 healthy controls. HD patients were prospectively followed up for five years (2009-2014). PAPP-A2 was measured by surface plasmon resonance biosensor, PAPP-A by time resolved amplified cryptate emission. Results: PAPP-A2, similarly as PAPP-A, was significantly increased in HD patients (median (interquartile range)) PAPP-A2: 6.2 (2.6-10.8) ng/mL, vs. 3.0 (0.7-5.9) ng/mL, p=0.006; PAPP-A: 18.9 (14.3-23.4) mIU/L, vs. 9.5 (8.4-10.5) mIU/L, p<0.001). In HD patients, PAPP-A2 correlated weakly but significantly with PAPP-A (τ=0.193, p=0.004). Unlike PAPP-A, PAPP-A2 was not significant for prognosis of HD patients when tested alone. There was a significant interaction between PAPP-A and PAPP-A2 on the mortality due to infection of HD patients (p=0.008). If PAPP-A was below median, mortality due to infection was significantly higher for patients with PAPP-A2 values above median than for patients with low PAPP-A2 levels (p=0.011). Conclusion: PAPP-A2 is increased in HD patients and interacts with PAPP-A on patients´ prognosis.

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Pregnancy-associated plasma protein A: spotlight on kidney diseases

Cited by 10 publications

References 57 publications

Metalloproteinase PAPP-A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis

Metalloproteinase PAPP-A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis

Cigarette Smoking Increases Pregnancy-associated Plasma Protein-A in Men

Pregnancy-Associated Plasma Protein A2 in Hemodialysis Patients: Significance for Prognosis

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